Neuropharmacology
The unit comprises the group of Hanns Ulrich Zeilhofer and the independent group headed by Dietmar Benke (Alumni since May 2025).
The Zeilhofer group focuses on sensory processing on the spinal cord circuits and on pain. The research of the Benke group was addressing the trafficking of G-protein coupled receptors and protein-protein interactions of GABA-B receptors.
Latest NEWS
Elena Neumann's latest publication in the Brithish Journal of Pharmacology (BJP)
A PK/PD study on antihyperalgesia by an α2/3-GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1-GABAA receptors
- Subtype selective positive allosteric modulators of GABAA receptors (GABAARs PAMs) exert antihyperalgesic effects in rodent models of chronic pain.
- TPA023B is an α2/α3 subtype selective, non-sedative, GABAAR PAM
- These antihyperalgesic effects do not undergo tolerance development and are likely mediated by non-canonical (γ1-)GABAARs.
- γ-1 GABAARs may be new potential targets for analgesic drugs.