PUBLICATIONS
ZORA Publication List
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Publications
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2014 |
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Zemoura K. and Benke D. (2014) Proteasomal degradation of γ-aminobutyric acidB receptors is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase Rtp6 and regulated by neuronal activity. J. Biol. Chem. 289, 7738-7746. |
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| 2010 | |
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Mohler H., Benke, D., Rudolph, U. and Fritschy, J.-M. (2010) GABAA receptors. |
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| 2007 | |
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Grampp, T., Sauter, K., Markovic, B. and Benke, D. (2007). γ-Aminobutyric acid type B receptors are constitutively internalized via the clathrin-dependent pathway and targeted to lysosomes for degradation. |
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| 2006 | |
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Studer, R., von Boehmer, L., Haenggi, T., Schweizer, C., Benke, D., Rudolph, U. and Fritschy J.-M. (2006). Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor α3 subunit-null mice. Eur. J. Neurosci. 24, 1307-1315 |
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Yee, B. K., Balic, E., Singer, P., Schwerdel, C., Grampp, T., Gabernet, L., Knuesel, I., Benke, D., Feldon, J., Mohler, H. and Boison, D. (2006).Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a pro-cognitive and anti-psychotic phenotypic profile. J. Neurosci. 26, 3169-3181 |
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| 2005 | |
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Yee, B.K., Keist, R., von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, R.C., Fritschy, J.-M., Bluethmann, H., Feldon, J., Möhler, H., Rudolph, U. (2005). A schizophrenia-related sensorimotor deficit links α3-containing GABAA receptors to a dopamine hyperfunction. Proc. Natl. Acad. Sci. USA 102, 17154-17159. |
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Sauter, K., Grampp, T., Fritschy, J.-M., Kaupmann, K., Bettler, B., Mohler, H. and Benke, D. (2005). Subtype-selective interaction with the transcription factor CAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABAB receptors. J. Biol. Chem. 280, 33566-33572 |
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| 2004 | |
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Benke, D., Fakitsas, P., Rogenmoser, C., Michel, C., Rudolph, U. and Mohler, H. (2004). Analysis of the presence and abundance of GABAA receptors containing two different types of α subunits in murine brain using point-mutated α-subunits. J. Biol. Chem. 279, 43654-43660 |
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| Fritschy, J.-M., Sidler, C., Parpan, F., Gassmann, M., Kaupmann, K., Bettler, B., and Benke, D. (2004). Independent maturation of the GABAB receptor subunits GABAB1 and GABAB2 during postnatal development in rodent brain. J. Comp. Neurol. 477, 235-252 | |
| 2002 | |
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Benke, D. Michel, C. and Mohler, H. (2002). Structure of GABAB receptors in rat retina. J. Recep. Sign. Transduc. Res. 22, 253-266 Structure of GABAB receptors in rat retina. J. Recep. Sign. Transduc. Res. 22, 253-266 |
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Crestani, F., Keist, R., Fritschy, J.-M., Benke, D., Vogt, K., Prut, L., Blüthmann, H., Mohler, H. and Rudolph, U. (2002). Trace fear conditioning involves hippocampal α5 GABAA receptors. Proc. Natl. Acad. Sci. USA 99, 8980-8985 |
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Gao, B., Wenzel, A., Grimm, C., Vavricka, S. R., Benke, D., Meier, P. J., Remè, C. E. (2002). Localization of organic anion transport protein 2 in the apical region of rat retina pigment epithelium. Invest. Ophtha. Visual Sci. 43, 510-514 Localization of organic anion transport protein 2 in the apical region of rat retina pigment epithelium. Invest. Ophtha. Visual Sci. 43, 510-514 |
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| 2001 | |
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Benke, D., Olah, A. and Mohler, H. (2001). Bio-Oss bone substitute contains carbonate but fails to display protein including TGFβ. Biomaterials 22, 1005-1012 |
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| 2000 | |
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Löw., K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Rülicke, T., Bluethmann, H., Mohler, H. and Rudolph, U. (2000). Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290, 131-134 Science 290, 131-134 |
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Gao, B., Hagenbuch, B., Kullak-Ublick, G. A., Benke, D., Aguzzi, A. and Meier, P. J. (2000). Organic anion-transporting polypeptides mediate transport of opioid peptides across the blood-brain barrier. J. Pharmacol. Exp. Therap. 294, 73-79 Organic anion-transporting polypeptides mediate transport of opioid peptides across the blood-brain barrier. J. Pharmacol. Exp. Therap. 294, 73-79 |
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Lorez, M., Benke, D., Lüscher, B., Mohler, H. and Benson, J. A. (2000). Single-channel properties of neuronal GABAA receptors from mice lacking the γ2-subunit. J. Physiol. 527.1, 11-31 |
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Sibille, E., Pavlides, C., Benke, D. and Toth, M. (2000). Genetic inactivation of the serotonin1A receptor in mice results in downregulation of major GABAA receptor alpha subunits, reduction of GABAA receptor binding, and benzodiazepine-resistant anxiety. J. Neurosci. 20, 2758-2765. |
Publications before year 2000
ZORA Publication List
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Publications
ZORA Publication List
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Publications
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2026
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Journal Article
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A PK/PD study on antihyperalgesia by an α2/3-GABA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1-GABA receptors British Journal of Pharmacology, bph.70301. https://doi.org/10.1111/bph.70301
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2025
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Journal Article
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Optimization of neuron-specific interfering peptides targeting GABA$_{B}$ receptor downregulation for proteolytic stability for conferring neuroprotection in a mouse model of cerebral ischemia Frontiers in Pharmacology, 16, 1576884. https://doi.org/10.3389/fphar.2025.1576884
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The E3 ubiquitin ligase MARCH1 mediates downregulation of plasma membrane GABA$_{B}$ receptors under ischemic conditions by inhibiting fast receptor recycling Scientific Reports, 15, 1330. https://doi.org/10.1038/s41598-025-85842-1
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2024
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Journal Article
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Probing PAC1 receptor activation across species with an engineered sensor ELife, 13, RP96496. https://doi.org/10.7554/eLife.96496
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Development of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release Nature Communications, 15, 5353. https://doi.org/10.1038/s41467-024-49712-0
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Restoring GABA$_{B}$ receptor expression in the ventral tegmental area of methamphetamine addicted mice inhibits locomotor sensitization and drug seeking behavior Frontiers in Molecular Neuroscience, 17, 1347228. https://doi.org/10.3389/fnmol.2024.1347228
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Book Section
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GABAB Receptors: Molecular Organization, Function, and Alternative Drug Development by Targeting Protein-Protein Interactions In G. Colombo (Ed.), The GABA$_B$ Receptors (pp. 3–39). Human Press. https://doi.org/10.1007/978-3-031-67148-7_1
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2023
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Journal Article
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Restoration of GABA$_{B}$ receptor expression in cerebral ischemia: a promising novel neuroprotective strategy Neural Regeneration Research, 18, 2659–2660. https://doi.org/10.4103/1673-5374.373704
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Sensitive multicolor indicators for monitoring norepinephrine in vivo Nature Methods, 20, 1426–1436. https://doi.org/10.1038/s41592-023-01959-z
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ERK1/2-Dependent Phosphorylation of GABA$_{B1}$(S867/T872), Controlled by CaMKIIβ, Is Required for GABA$_{B}$ Receptor Degradation under Physiological and Pathological Conditions International Journal of Molecular Sciences, 24, 13436. https://doi.org/10.3390/ijms241713436
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Adamtsl3 mediates DCC signaling to selectively promote GABAergic synapse function Cell Reports, 42, 112947. https://doi.org/10.1016/j.celrep.2023.112947
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Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution ELife, 12, RP86628. https://doi.org/10.7554/elife.86628.3
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Targeting the interaction of GABA$_{B}$ receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices Brain Pathology, 33, e13099. https://doi.org/10.1111/bpa.13099
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2022
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Journal Article
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Calreticulin mutations affect its chaperone function and perturb the glycoproteome Cell Reports, 41, 111689. https://doi.org/10.1016/j.celrep.2022.111689
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Protein phosphatase 2A regulation of GABAB receptors normalizes ischemia-induced aberrant receptor trafficking and provides neuroprotection Frontiers in Molecular Neuroscience, 15, 1015906. https://doi.org/10.3389/fnmol.2022.1015906
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Targeting the Interaction of GABA B Receptors With CHOP After an Ischemic Insult Restores Receptor Expression and Inhibits Progressive Neuronal Death Frontiers in Pharmacology, 13, 870861. https://doi.org/10.3389/fphar.2022.870861
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Book Section
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GABA B Receptors and Pain In Current Topics in Behavioral Neurosciences (Vol. 52, pp. 213–239). Springer. https://doi.org/10.1007/7854_2020_130
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2021
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Journal Article
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A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia Pain, 162, 2436–2445. https://doi.org/10.1097/j.pain.0000000000002236
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Sustained Baclofen-Induced Activation of GABAB Receptors After Cerebral Ischemia Restores Receptor Expression and Function and Limits Progressing Loss of Neurons Frontiers in Molecular Neuroscience, 14, 726133. https://doi.org/10.3389/fnmol.2021.726133
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Corrigendum: Adeno-Associated Virus-Mediated Gain-of-Function mPCSK9 Expression in the Mouse Induces Hypercholesterolemia, Monocytosis, Neutrophilia, and a Hypercoagulative State Frontiers in Cardiovascular Medicine, 8, 820282. https://doi.org/10.3389/fcvm.2021.820282
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