PUBLICATIONS

SELECTED RECENT PUBLICATIONS

2021  
Stucky B*, Clark I*, Azza Y, Karlen W, Achermann P, Kleim B, and Landolt HP. Validation of Fitbit Charge 2TM sleep and heart rate estimates against polysomnography in shift workers: a naturalistic study. J Med Internet Res, in press.  
Clark I*, Stucky B*, Azza Y, Schwab P, Müller S, Weibel D, Button D, Karlen W, Seifritz E, Kleim B, and Landolt HP. Diurnal variations in multi-sensor wearable-derived sleep characteristics in morning- and evening-type shift workers under naturalistic conditions. Chronobiol Int, in press.  
Weibel J, Lin YS, Landolt HP, Berthomier C, Brandewinder M, Kistler J, Rehm S, Rentsch KM, Meyer M, Borgwardt S, Cajochen C, and Reichert CF. Regular caffeine intake delays REM sleep promotion and attenuates sleep quality in healthy men. J Biol Rhythms, in press.  
Lin YS, Weibel J, Landolt HP, Santini F, Meyer M, Brunmair J, Meier-Menches SM, Gerner C, Borgwardt S, Cajochen C, and Reichert CF. Daily caffeine intake induces concentration-dependent medial temporal plasticity in humans: A multimodal double-blind randomized controlled trial. Cereb Cortex 31, 3096-3106, 2021.  
Weibel J, Lin YS, Landolt HP, Kistler J, Rehm S, Rentsch KM, Slawik H, Borgwardt S, Cajochen C, and Reichert CF. The impact of daily caffeine intake on nighttime sleep in young adult men. Sci Rep 11, e4668, 2021.  

2020

 
Baur DM, Lange D, Elmenhorst EM, Elmenhorst D, Bauer A, Aeschbach D, and Landolt HP. Coffee effectively attenuates impaired attention in ADORA2A C/C-allele carriers during chronic sleep restriction. Prog Neuropsychopharmacol Biol Psychiatry, 2021 Jul 13;109:110232.
 doi: 10.1016/j.pnpbp.2020.110232. Epub 2020 Dec 26.
 
Landolt HP, and Werth E. The effects of various pharmacological treatments on sleep. In: European Sleep Medicine Textbook. Bassetti CL, Paunio T and McNicholas W (Eds.). 2nd edition. Wiley, 2020 Dec.  
Holst SC, and Landolt HP. Acute and chronic effects of sleep deprivation. In: European Sleep Medicine Textbook. Bassetti CL, Paunio T and McNicholas W (Eds.). 2nd edition. Wiley, 2020 Dec.  
Landolt HP, and Dijk DJ. Genetic and genomic basis of sleep in healthy humans. In: Principles and Practice of Sleep Medicine. Kryger MH, Roth T, Dement WC (Eds.). 7th edition. Elsevier, in press.  
Ulf Larsen SM, Landolt HP, Berger W, Nedergaard M, Knudsen GM, Holst SC. Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep. PLoS Biol 18, e3000623 (2020). DOI: 10.1371/journal.pbio.3000623  
Hubbard J, Gent TC, Hoekstra MMB, Emmenegger Y, Mongrain V, Landolt HP, Adamantidis AR, and Franken P. Rapid fast-delta decay following prolonged wakefulness marks a phase of wake-inertia in NREM sleep. Nature Comm 11, e3130 (2020). doi: 10.1038/s41467-020-16915-0  

Weibel J, Lin YS, Landolt HP, Garbazza C, Kolodyazhniy V, Kistler J, Rehm S, Rentsch K, Borgward S, Cajochen C, Reichert CF. Caffeine-dependent changes of sleep-wake regulation: Evidence for adaptation after repeated intake. Prog Neuropsychopharmacol Biol Psychiatry 99, e109851 (2020); DOI: 10.1016/j.pnpbp.2019.109851

 

Lazarus M, Yoo O, Landolt HPAdenosinergic control of sleep. In: Principles and Practice of Sleep Medicine. Kryger MH, Roth T, Dement WC (Eds.). 7th edition. Elsevier, in press.

 

Holst SC, Di Chiara M, Landolt HP. Neurobiologische Grundlagen von Schlaf, Wachheit und Schlaf-Wachstörungen. In: Psychosomatik - neurobiologisch fundiert und evidenzbasiert: Ein Lehr- und Handbuch (Hrsg. Egle, Heim, Strauß, von Känel). Kohlhammer, Stuttgart. pp. 436-441 (2020)

 

Holst SC, Werth E, Landolt HP. Nicht-Insomnie bedingte Schlaf-Wachstörungen. In: Psychosomatik - neurobiologisch fundiert und evidenzbasiert: Ein Lehr- und Handbuch (Hrsg. Egle, Heim, Strauß, von Känel). Kohlhammer, Stuttgart. pp. 449-458 (2020)

 
Moreira CG, Morawska MM, Baumann A, Masneuf S, Linnebank M, Sommerauer M, Landolt HP, Noain D, and Baumann CR. Improved functional and histochemical outcomes in L-DOPA plus tolcapone treated VMAT2-deficient mice. Neuropharmacol 181, e108353, 2020.  

2019

 

Lehmann M, Hock A, Zölch N, Landolt HP*, and Seifritz E* (* shared senior authorship)

Dynamic metabolic changes in the human thalamus at the transition from waking to sleep - insights from simultaneous functional MR spectroscopy and polysomnography
Front Neurosci, ​​13, 1158, 2019 Oct 30, eCollection 2019

 

Dornbierer DA, Boxler M, Voegel CD, Stucky B, Steuer A, Binz TM, Baumgartner MR, Baur DM, Quednow BB, Kraemer T, Seifritz E, Landolt HP*, and Bosch OG*. (* shared senior authors)
Nocturnal gamma-hydroxybutyrate reduces cortisol awakening response and morning kyrunenine pathway metabolites in healthy volunteers.
Int J Neuropsychopharmacol, 22(10):631-639

 

Landolt HP, and Dijk. (Eds.)
Sleep-Wake Neurobiology and Pharmacology.
Handbook of Experimental Pharmacology, Volume 253, 481 pages.
Springer International Publishing, 2019.

Sleep-Wake Neurobiology and Pharmacology - cover

 

Weigend S, Holst SC, Treyer V, O'Gorman Tuura RF, Meier J, Ametamey SM, Buck A, and Landolt HP. Dynamic Changes in Cerebral and Peripheral Markers of Glutamatergic Signaling Across the Human Sleep-Wake Cycle. Sleep, 42(11):zsz161. Item availability may be restricted. doi: 10.1093/sleep/zsz161.

 

Dijk DJ, and Landolt HP. Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics. Handb Exp Pharmacol, 2019;

Sleep-Wake Neurobiology and Pharmacology. Cham: Springer, 441-481. doi: 10.1007/164_2019_243.

 

Dornbierer DA, Baur DM, Stucky B, Quednow BB, Krämer Th, Seifritz E, Bosch OG, and Landolt HP.
Neurophysiological signature of gamma-hydroxybutyrate augmented sleep in healthy male volunteers may reflect biomimetic sleep enhancement: A randomized controlled trial.
Neuropsychopharmacol, (2019) 44(11):1985-1993;

doi: 10.1038/s41386-019-0382-z.

 

Satterfield BC, Stucky B, Landolt HP, and van Dongen H.
Unraveling the genetic underpinnings of sleep deprivation-induced impairments in human cognition.
Prog Brain Res, 2019; 
246:127-158.

 

Holst SC, Werth E, Landolt HP Pharmakotherapie von Schlaf-Wachstörungen. Praxis 2019; 108(2):131-138 · January 2019 .

 
2018  

Landolt HP, Holst SC, Valomon A Clinical and Experimental Human Sleep-Wake Pharmacogenetics. Handb Exp Pharmacol. 2018 Nov 16; doi: 10.1007/164_2018_175

 

Weigend S, Holst SC, Meier J, Brock M, Kohler M, Landolt HP Prolonged Waking and Recovery Sleep Affect the Serumg MicroRNA Profile in Humans. Clocks & Sleep. 2018 Nov 22; 1(1):75-86;  https://doi.org/10.3390/clockssleep1010008

 

Weigend S, Holst SC, Treyer V, O'Gorman Tuura RL, Meier J, Ametamey SM, Buck A, Landolt HP Dynamic Changes in Cerebral and Peripheral Markers of Glutamatergic Signaling Across the Human Sleep-Wake Cycle. bioRxiv. 2018 Dec 13;

 
Holst SC, Landolt HP Sleep-Wake Neurochemistry, Sleep Medicine Clinics, Sleep Med Clin. 2018 Jun;13(2):137-146 .  
Valomon A, Holst SC, Borrello A, Weigend S, Müller T, Berger W, Baumann CR, and Landolt HP. Effects of COMT Genotype and Tolcapone on Lapses of Sustained Attention After Sleep
Deprivation in Healthy Young Men.
Neuropsychopharmacol, Neuropsychopharmacology. 2018 Jun;43(7):1599-1607 .
 
2017  
Holst SC, Sousek A, Hefti K, Saberi‐Moghadam S, Buck A, Ametamey SM, Scheidegger M, Franken P, Henning A, Seifritz E, Tafti M, and Landolt HP. Cerebral mGluR5 availability contributes to elevated sleep need and behavioral adjustment after sleep deprivation. eLife 6, e28751, 2017.  
Clark I, Landolt HP. Coffee, caffeine and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev. 2017 Feb;31:70-78. Epub 2016 Jan 30  
Holst SC, Müller T, Valomon A, Seebauer B, Berger W, Landolt HP.

Functional Polymorphisms in Dopaminergic Genes Modulate Neurobehavioral and Neurophysiological Consequences of Sleep Deprivation. Sci Rep. 2017 Apr 10;7:45982.

DOWNLOAD (PDF, 1 MB)
Landolt HP, Dijk DJ. Genetics and genomic basis of sleep in healthy humans. In: Kryger MH, Roth T, Dement WC (ed.). Principles and Practice in Sleep Medicine. Philadelphia: Elsevier, 310-321.  
Urry E, Jetter A, Holst SC, Berger W., Spinas GA, Langhans W, Landolt HP, A case-control field study on the relationships among type 2 diabetes, sleepiness and habitual caffeine intakeJ Psychopharmacol. 2017 Feb;31(2):233-242. Epub 2016 Sep 27.  
2016  
Urry E, Jetter A, and Landolt HP. Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake. Nutr Metab, 2016 Oct 6;13:66. eCollection 2016. DOWNLOAD (PDF, 514 KB)
Urry E, Jetter A, Holst SC, Berger W, Spinas GA, Langhans W, and Landolt HP. A case-control field study on the relationships among type 2 diabetes, sleepiness, and habitual caffeine intake. J Psychopharm, J Psychopharmacol 2017 Feb;31(2):233-242 Epub 2016 Sep 27. DOWNLOAD (PDF, 493 KB)
Landolt HP, and Dijk DJ. Genetics and Genomic Basis of Sleep in Healthy Humans. In: Principles and Practice of Sleep Medicine. Kryger MH, Roth T, Dement WC (Eds.). 6th edition. Elsevier, in press.  
Landolt HP. Importance des différences interindividuelles de sensibilité à la caféine en médecine du sommeil : rôles de  l’adénosine et de la dopamine. Médicine du Sommeil, in press. DOWNLOAD (PDF, 125 KB)
Landolt HP, and Holst SC. Ionic Control of Sleep and Wakefulness. Science 352, 517-518, 2016. [Perspective] DOWNLOAD (PDF, 333 KB)
Landolt HP. Individuelle Koffeinempfindlichkeit: Implikationen für eine personalisierte Schlafmedizin? Praxis 105, 563-568, 2016. DOWNLOAD (PDF, 237 KB)
Clark I and Landolt HP. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev. 2016, 2016 Jan 30. pii: S1087-0792(16)00015-0.
Holst SC, Valomon A and Landolt HP. Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy. Annu Rev Pharmacol Toxicol. 2016, Jan 6;56:577-603.
2015  
Landolt HP. CIRCADIAN RHYTHMS. Caffeine, the circadian clock, and sleep. Science. 2015, Sep 18;349(6254):1289.
Dauvilliers Y, Tafti M and Landolt HP. Catechol-O-methyltransferase, dopamine and sleep-wake regulation. Sleep Med Rev. 2015, Aug;22:47-53.
Urry E and Landolt HP. Adenosine, caffeine and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics. Curr Top Behav Neurosci. 2015;25:331-66.
2014  
Tinguely G, Landolt HP and Cajochen C. [Sleep habits, sleep quality and sleep medicine use of the Swiss population result]. Ther Umsch. 2014, Nov;71(11):637-46.
Thomann J, Baumann CR, Landolt HP and Werth E. Psychomotor vigilance task demonstrates impaired vigilance in disorders with excessive daytime sleepiness. J Clin Sleep Med. 2014, Sep 15;10(9):1019-24.
Chellappa SL, Viola AU, Schmidt C, Bachmann V, Gabel V, Maire M, Reichert CF, Valomon A, Landolt HP and Cajochen C. Light modulation of human sleep depends on a polymorphism in the clock gene Period3. Behav Brain Res. 2014, Sep 1;271:23-9.
Valomon A, Holst SC, Bachmann V, Viola AU, Schmidt C, Zürcher J, Berger W, Cajochen C and Landolt HP. Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults. Chronobiol Int. 2014, Jun;31(5):705-14.
Olbrich E, Landolt HP and Achermann P. Effect of prolonged wakefulness on electroencephalographic oscillatory activity during sleep. J Sleep Res. 2014, Jun;23(3):253-60.
Reichert CF, Maire M, Gabel V, Viola AU, Kolodyazhniy V, Strobel W, Götz T, Bachmann V, Landolt HP Cajochen C and Schmidt C. Insights into behavioral vulnerability to differential sleep pressure and circadian phase from a functional ADA polymorphism. J Biol Rhythms. 2014, Apr;29(2):119-30.
Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci. 2014, Jan 8;34(2):566-73.
Maire M, Reichert CF, Gabel V, Viola AU, Krebs J, Strobel W, Landolt HP. Bachmann V, Cajochen C and Schmidt C. Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation. Front Behav Neurosci.. 2014 Mar 6;8:59.
Reichert CF, Maire M, Gabel V, Hofstetter M, Viola AU, Kolodyazhniy V, Strobel W, Goetz T, Bachmann V, Landolt HP Cajochen C and Schmidt C. The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements. PLoS One. 2014, 9(12):e113734.  
2013  
Bosch OG, Rihm JS, Scheidegger M, Landolt HP, Stämpfli P, Brakowski J, Esposito F, Rasch B, and Seifritz E. Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans. Proc Natl Acad Sci USA, 110, 19597-15602 (2013
Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry, 73, 161-168 (2013)
2012  
Landolt HP, Rétey JV and Adam M. Reduced neurobehavioral impairment from sleep deprivation in older adults: Contribution of adenosinergic mechanisms. Front Neurol, 3, 62 (2012)
Chellappa SL, Viola AU, Schmidt C, Bachmann V, Gabel V, Maire M, Reichert CF, Valomon A, Götz T, Landolt HP and Cajochen C. Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3. J Clin Endocrinol Metab, 97, E433-E437 (2012)
Bachmann V, Klein C, Bodenmann S, Schäfer N, Berger W, Brugger P and Landolt HP. The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity. Sleep, 35, 335-344, (2012)
Bodenmann S, Hohoff C, Freitag C, Deckert J, Rétey JV, Bachmann V and Landolt HP. Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioral performance and sleep EEG after sleep deprivation. Br J Pharmacol, 165, (2012)
   
Entire Publication Record DOWNLOAD (PDF, 289 KB)