Our research focuses on the development of protein-based biosensors to study cell-to-cell communication and signaling. We aim to take a comprehensive approach combining state of the art molecular biology techniques, custom-designed screening assays, ex vivo and in vivo imaging methods. We are also very interested in establishing cross-disciplinary collaborations.
Among other projects, we are currently focusing on optimizing and expanding the toolbox of genetically encoded sensors for neurotransmitters, with three current efforts:
- Continued optimization of the dLigth1-type dopamine sensors for improved in vivo sensitivity
- Development and optimization of various neuropeptide sensors for imaging applications in awake behaving mice
- Engineering and validation of neurotransmitter sensors with modified spectral properties for new in vivo imaging applications