Our research focuses on the development of protein-based biosensors to study cell-to-cell communication and signaling. We aim to take a comprehensive approach combining state of the art molecular biology techniques, custom-designed screening assays, ex vivo and in vivo imaging methods. We are also very interested in establishing cross-disciplinary collaborations.

Among other projects, we are currently focusing on optimizing and expanding the toolbox of genetically encoded sensors for neurotransmitters, with three current efforts:

1. Continued optimization of the dLigth1-type dopamine sensors for improved in vivo sensitivity
2. Development and optimization of various neuropeptide sensors for imaging applications in awake behaving mice
3. Engineering and validation of neurotransmitter sensors with modified spectral properties for new in vivo imaging applications