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Institute of Pharmacology and Toxicology Toxicology



Zora pulication list

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Reetz MT, Bocola M, Wang LW, Sanchis J, Cronin A, Arand M, Zou J, Archelas A, Bottalla AL, Naworyta A, Mowbray SL, Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage. J Am Chem Soc. (2009) Jun 3;131(21):7334-43.
Decker M, Arand M, Cronin A, Mammalian epoxide hydrolases in xenobiotic metabolism and signalling. Arch Toxicol. (2009) Apr; 83(4):297-318.
Cronin A, Homburg S, Dürk H, Richter I, Adamska M, Frère F, Arand M, Insights into the catalytic mechanism of human sEH phosphatase by site-directed mutagenesis and LC-MS/MS analysis.
J Mol Biol. (2008), 383: 627-40.
Harris TR, Aronov PA, Jones PD, Tanaka H, Arand M, Hammock BD Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules. Arch Biochem Biophys. (2008) 472: 139-49.
Toxicological comments to the discussion about REACH, H. Greim, M. Arand, H. Autrup, H.M. Bolt, J. Bridges, E. Dybing, R. Glomot, V. Foa, R. Schulte-Hermann, Arch Toxicol 2006, 80: 121-124. Reply to the letter to the editor: the need for a new toxicity testing and risk analysis paradigm to implement REACH or any other large scale testing initiative, by B.J. Blaauboer and M.E. Andersen, Arch Toxicol (2007), 81: 385-387. 
Greim H., Arand M., Autrup H., Hermann M., Bridges J., Dybing E., Glomot R., Foa V., Schulte-Hermann R. Toxicological comments to the discussion about REACH. Arch Toxicol (2006) 80: 121–124
van Loo B, Kingma J, Arand M, Wubbolts MG, Janssen DB. Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis. Appl Environ Microbiol. 2006 Apr; 72(4):2905-17.  
Trösken, E. R., Adamska M., Arand M., Zarn J. A., Patten C., Völkel W. , Lutz W. K. Comparison of lanosterol-14αdemethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. Toxikology (2006) 228: 24-32
Arand M, Cronin A, Adamska M, Oesch F. Epoxide hydrolases: structure, function, mechanism, and assay. Methods Enzymol. 2005; 400:569-88. Review. PMID: 16399371  
Johansson P, Unge T, Cronin A, Arand M, Bergfors T, Jones TA, Mowbray SL. Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function. J Mol Biol. 2005Sep 2;351(5):1048-56.
Frère, F. Reents, H., Schubert, W. D., Heinz, D. W., Jahn, D. (2005) Tracking the evolution of porphobilinogen synthase metal dependence in vitro. J. Mol. Biol. 345, 1059-1070.
Huarte, E., Karbach, J., Gnjatic, S., Bender, A., Jäger, D., Arand, M., Atanackovic, D., Skipper, J., Ritter, G., Chen, Y. T., Old, L. J., Knuth, A. and Jäger, E. (2004) HLA-DP4 expression and immunity to NY-ESO-1: correlation and characterization of cytotoxic CD4+ CD25- CD8- T cell clones. Cancer Immun. 4, 15.
Rojas, A. L., Nagem, R. A., Neustroev, K. N., Arand, M., Adamska, M., Eneyskaya, E. V., Kulminskaya, A. A., Garratt, R. C., Golubev, A. M. and Polikarpov, I. (2004) Crystal structures of beta-galactosidase from Penicillium sp. and its complex with galactose. J. Mol. Biol. 343, 1281-1292.
Monterde, M. I., Lombard, M., Archelas, A., Cronin, A., Arand, M. and Furstoss, R. (2004) Enzymatic transformations. Part 58: Enantioconvergent biohydrolysis of styrene oxide derivatives catalysed by the Solanum tuberosum epoxide hydrolase. Tetrahedron: Asymmetry 15, 2801-2805.
Reetz, M. T., Torre, C., Eipper, A., Lohmer, R., Hermes, M., Brunner, B., Maichele, A., Bocola, M., Arand, M., Cronin, A., Genzel, Y., Archelas, A. and Furstoss, R. (2004) Enhancing the enantioselectivity of an epoxide hydrolase by directed evolution. Org. Lett. 6, 177-180.
Arand, M., Cronin, A., Oesch, F., Mowbray, S. L. and Jones, T. A. (2003) The telltale structures of epoxide hydrolases. Drug Metab. Rev. 35, 365-383.
Kulminskaya, A. A., Arand, M., Eneyskaya, E. V., Ivanen, D. R., Shabalin, K. A., Shishliannikov, S. M., Saveliev, A. N., Korneeva, O. S. and Neustroev, K. N. (2003) Biochemical characterization of Aspergillus awamori exoinulinase: substrate binding characteristics and regioselectivity of hydrolysis. Biochim. Biophys. Acta 1650, 22-29. 
Arand, M., Hallberg, B. M., Zou, J., Bergfors, T., Oesch, F., van der Werf, M. J., De Bont, J. A., Jones, T. A. and Mowbray, S. L. (2003) Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. EMBO J. 22, 2583-2592.
Arand, M., Herrero Plana, M. E., Hengstler, J. G., Lohmann, M., Cronin, A. and Oesch, F. (2003) Detoxification strategy of epoxide hydrolase - the basis for a threshold in chemical carcinogenesis. EXCLI J. 2, 22-30.
Cronin, A., Mowbray, S., Dürk, H., Homburg, S., Fleming, I., Fisslthaler, B., Oesch, F. and Arand, M. (2003) The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase. Proc Natl Acad Sci U S A 100, 1552-1557.
Moser, J., Frère, F., Heinz, D. W., Jahn, D., Schubert, W. D., (2003) Glutamat auf Abwegen: Die tRNA-abhängige Tetrapyrrol-Biosynthese. Biospektrum, 2, 133-137.
Frère, F., Schubert, W. D., Stauffer, F., Frankenberg, N., Neier, R., Jahn, D., Heinz, D. W. (2002) Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism. J. Mol. Biol. 320, 237-47.
Haufroid, V., Jakubowski, M., Janasik, B., Ligocka, D., Buchet, J. P., Bergamaschi, E., Manini, P., Mutti, A., Ghittori, S., Arand, M., Hangen, N., Oesch, F., Hirvonen, A. and Lison, D. (2002) Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. Pharmacogenetics 12, 691-702.
Jäger, E., Karbach, J., Gnjatic, S., Jäger, D., Maeurer, M., Atmaca, A., Arand, M., Skipper, J., Stockert, E., Chen, Y.-T., Old, L. J. and Knuth, A. (2002) Identification of a naturally processed NY-ESO-1 peptide recognized by CD8* T cells in the context of HLA-B51.
 Cancer Immunity 2, 12.
Jäger, D., Stockert, E., Karbach, J., Herrlinger, K., Atmaca, A., Arand, M., Chen, Y.-T., Gnjatic, S., Old, L. J., Knuth, A. and Jäger, E. (2002) Urine antibody against human cancer antigen NY-ESO-1. Cancer Immunity 2, 10.
Summerer, S., Hanano, A., Utsumi, S., Arand, M., Schuber, F. and Blée, E. (2002) Stereochemical features of the hydrolysis of 9,10-epoxystearic acid catalysed by plant and mammalian epoxide hydrolases. Biochem J 366, 471-480.
Vodicka, P., Koskinen, M., Arand, M., Oesch, F. and Hemminki, K. (2002) Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring. Mutat Res 511, 239-254.
Arand, M., Golubev, A. M., Neto, J. R., Polikarpov, I., Wattiez, R., Korneeva, O. S., Eneyskaya, E. V., Kulminskaya, A. A., Shabalin, K. A., Shishliannikov, S. M., Chepurnaya, O. V. and Neustroev, K. N. (2002) Purification, characterization, gene cloning and preliminary X-ray data of the exo-inulinase from Aspergillus awamori.
 Biochem J 362, 131-135.
Ringhoffer, M., Schmitt, M., Karbach, J., Jäger, E., Oesch, F. and Arand, M. (2001) Quantitative assessment of the expression of melanoma-associated antigens by non-competitive reverse transcription polymerase chain reaction. Int. J. Oncol. 19, 983-989.
Härtter, S., Wang, X., Weigmann, H., Friedberg, T., Arand, M., Oesch, F. and Hiemke, C. (2001) Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin. J. Clin. Psychopharmacol. 21, 167-174.

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