Publications

ZORA Publication List

Publications

• 2026

  • Journal Article

    • Kissling, L., Pietrafesa, F., Ranucci, M., Boeck, D., Mathis, N., Kulcsár, P. I., Ioannidi, E., Schmidheini, L., Tálas, A., Villiger, E. A., Wildner, H., Zhao, X., Kompotis, K., Zeilhofer, H. U., & Schwank, G. (2026). Prime editing of a pathogenic allele ameliorates seizure phenotypes in a GEFS mouse model Science Translational Medicine, 18, eadz2557. https://doi.org/10.1126/scitranslmed.adz2557
    • Ganley, R., Sousa, M., Ji, G., Ranucci, M., Beccarini, C., Werder, K., Pietrafesa, F., d’Aquin, S., Akyüz, T., Hubli, M., Schweinhardt, P., Neugebauer, V., Hoon, M., Wildner, H., & Zeilhofer, H. U. (2026). Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon Nature Communications, 17, 4765. https://doi.org/10.1038/s41467-026-71289-z
    • Haenraets, K., Ganley, R. P., Pietrafesa, F., MacDonald, D. I., Sousa, M., Schalbetter, S. M., Mendes, R., Luzi, F., Wildner, H., & Zeilhofer, H. U. (2026). GABAergic Gbx1 neurons of the superficial dorsal horn are critical elements of a spinal circuit for stress-induced analgesia Neuron, Epub ahead of print. https://doi.org/10.1016/j.neuron.2026.01.033
    • Ba, W., Harding, E. C., Nollet, M., Tossell, K., Li, L.-L., Wong, S., Soto, B. A., Yustos, R., Li, L., Ostaszewska, J., Zeilhofer, H. U., Vyssotski, A. L., Courtney, M. J., Wisden, W., & Franks, N. P. (2026). Wake-active brainstem GABA neurons signal sleep pressure by upregulating AMPA receptors to drive recovery sleep Current Biology, 36, 2823-2839.e4. https://doi.org/10.1016/j.cub.2026.04.059
    • Neumann, E., Popa, M. O., Elvers, K. T., Oyama, M., Ulrich, D., Hanley, M., Feng, G. J., Hathaway, T., Ralvenius, W. T., Grampp, T., Benke, D., Atack, J. R., & Zeilhofer, H. U. (2026). A PK/PD study on antihyperalgesia by an α2/3-GABA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1-GABA receptors British Journal of Pharmacology, 183, 2324–2340. https://doi.org/10.1111/bph.70301

• 2025

  • Journal Article

    • Zhang, M.-D., Kupari, J., Su, J., Magnusson, K. A., Hu, Y., Calvo-Enrique, L., Usoskin, D., Albisetti, G. W., Ceder, M. M., Henriksson, K., Leavitt, A. D., Zeilhofer, H. U., Hökfelt, T., Lagerström, M. C., & Ernfors, P. (2025). Neural ensembles that encode nocifensive mechanical and heat pain in mouse spinal cord Nature Neuroscience, 28, 1012–1023. https://doi.org/10.1038/s41593-025-01921-6
    • Farah, A., Patel, R., Poplawski, P., Wastie, B. J., Tseng, M., Barry, A. M., Daifallah, O., Dubb, A., Paul, I., Cheng, H. lao, Feroz, F., Su, Y., Chan, M., Zeilhofer, H. U., Price, T. J., Bennett, D. L., Bannister, K., & Dawes, J. M. (2025). A role for leucine-rich, glioma inactivated 1 in regulating pain sensitivity Brain : A Journal of Neurology, 148, 1001–1014. https://doi.org/10.1093/brain/awae302

• 2024

  • Journal Article

    • Maleeva, G., Nin-Hill, A., Wirth, U., Rustler, K., Ranucci, M., Opar, E., Rovira, C., Bregestovski, P., Zeilhofer, H. U., König, B., Alfonso-Prieto, M., & Gorostiza, P. (2024). Light-Activated Agonist-Potentiator of GABA$_{A}$ Receptors for Reversible Neuroinhibition in Wildtype Mice Journal of the American Chemical Society, 146, 28822–28831. https://doi.org/10.1021/jacs.4c08446
    • Neumann, E., Cramer, T., Acuña, M. A., Scheurer, L., Beccarini, C., Luscher, B., Wildner, H., & Zeilhofer, H. U. (2024). γ1 GABA$_{A}$Receptors in Spinal Nociceptive Circuits Journal of Neuroscience, 44, e0591242024. https://doi.org/10.1523/jneurosci.0591-24.2024
    • Tapernoux, M., Vermij, S., Metzger, G., & Zeilhofer, H. U. (2024). The Swiss National MD-PhD Grants Programme: an analysis of the career trajectories of grant recipients between 1992 and 2021 Schweizerische Medizinische Wochenschrift, 154, 3615. https://doi.org/10.57187/s.3615

• 2023

  • Journal Article

    • Davis, O. C., Dickie, A. C., Mustapa, M. B., Boyle, K. A., Browne, T. J., Gradwell, M. A., Smith, K. M., Polgár, E., Bell, A. M., Kókai, É., Watanabe, M., Wildner, H., Zeilhofer, H. U., Ginty, D. D., Callister, R. J., Graham, B. A., Todd, A. J., & Hughes, D. I. (2023). Calretinin-expressing islet cells are a source of pre- and post-synaptic inhibition of non-peptidergic nociceptor input to the mouse spinal cord Scientific Reports, 13, 11561. https://doi.org/10.1038/s41598-023-38605-9
    • Sirucek, L., Ganley, R. P., Zeilhofer, H. U., & Schweinhardt, P. (2023). Diffuse noxious inhibitory controls and conditioned pain modulation: a shared neurobiology within the descending pain inhibitory system? Pain, 164, 463–468. https://doi.org/10.1097/j.pain.0000000000002719
    • Puig-Bosch, X., Ballmann, M., Bieletzki, S., Antkowiak, B., Rudolph, U., Zeilhofer, H. U., & Rammes, G. (2023). Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABA$_{A}$ Receptors without Affecting Synaptic Plasticity International Journal of Molecular Sciences, 24, 9056. https://doi.org/10.3390/ijms24109056
    • Frezel, N., Ranucci, M., Foster, E., Wende, H., Pelczar, P., Mendes, R., Ganley, R. P., Werynska, K., d’Aquin, S., Beccarini, C., Birchmeier, C., Zeilhofer, H. U., & Wildner, H. (2023). c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy Cell Reports, 42, 112295. https://doi.org/10.1016/j.celrep.2023.112295
    • Ganley, R. P., de Sousa, M. M., Werder, K., Öztürk, T., Mendes, R., Ranucci, M., Wildner, H., & Zeilhofer, H. U. (2023). Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn ELife, 12, e78689. https://doi.org/10.7554/eLife.78689
    • Balakrishnan, K., Hleihil, M., Bhat, M. A., Ganley, R. P., Vaas, M., Klohs, J., Zeilhofer, H. U., & Benke, D. (2023). Targeting the interaction of GABA$_{B}$ receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices Brain Pathology, 33, e13099. https://doi.org/10.1111/bpa.13099
    • Albisetti, G. W., Ganley, R. P., Pietrafesa, F., Werynska, K., Magalhaes de Sousa, M., Sipione, R., Scheurer, L., Bösl, M. R., Pelczar, P., Wildner, H., & Zeilhofer, H. U. (2023). Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold Neuron, 111, 92-105.e5. https://doi.org/10.1016/j.neuron.2022.10.008
    • Werynska, K., Neumann, E., Cramer, T., Ganley, R. P., Gingras, J., & Zeilhofer, H. U. (2023). A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons Journal of Physiology, 601, 4121–4133. https://doi.org/10.1113/JP284589

• 2022

  • Journal Article

    • Souza, G. M. P. R., Stornetta, D. S., Vitali, A. J., Wildner, H., Zeilhofer, H. U., Campbell, J. N., & Abbott, S. B. G. (2022). Chemogenetic activation of noradrenergic A5 neurons increases blood pressure and visceral sympathetic activity in adult rats American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 323, R512–R531. https://doi.org/10.1152/ajpregu.00119.2022
    • Trendafilova, T., Adhikari, K., Schmid, A. B., Patel, R., Polgár, E., Chisholm, K. I., Middleton, S. J., Boyle, K., Dickie, A. C., Semizoglou, E., Perez-Sanchez, J., Bell, A. M., Ramirez-Aristeguieta, L. M., Khoury, S., Ivanov, A., Wildner, H., Ferris, E., Chacón-Duque, J.-C., Sokolow, S., … et al. (2022). Sodium-calcium exchanger-3 regulates pain “wind-up”: From human psychophysics to spinal mechanisms. Neuron, 110, 2571-2587.e13. https://doi.org/10.1016/j.neuron.2022.05.017

Pagination

ZORA Publication List

Publications

• 2026

  • Journal Article

    • Neumann, E., Popa, M. O., Elvers, K. T., Oyama, M., Ulrich, D., Hanley, M., Feng, G. J., Hathaway, T., Ralvenius, W. T., Grampp, T., Benke, D., Atack, J. R., & Zeilhofer, H. U. (2026). A PK/PD study on antihyperalgesia by an α2/3-GABA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1-GABA receptors British Journal of Pharmacology, 183, 2324–2340. https://doi.org/10.1111/bph.70301

• 2025

  • Journal Article

    • Hunn, C., Nöthiger, C. B., Braun, J., Sen, Y., Sen, A., Akbas, S., Hoffmann, M., Neumann, E., Gasciauskaite, G., Tscholl, D. W., & Roche, T. R. (2025). User-Centered Redesign of Monitoring Alarms: A Pre-Post Study on Perception, Functionality, and Recognizability Following Real-Life Clinical Implementation Healthcare, 13, 3033. https://doi.org/10.3390/healthcare13233033

• 2024

  • Journal Article

    • Neumann, E., Cramer, T., Acuña, M. A., Scheurer, L., Beccarini, C., Luscher, B., Wildner, H., & Zeilhofer, H. U. (2024). γ1 GABA$_{A}$Receptors in Spinal Nociceptive Circuits Journal of Neuroscience, 44, e0591242024. https://doi.org/10.1523/jneurosci.0591-24.2024

• 2023

  • Journal Article

    • Neumann, E., Sahli, S. D., Kaserer, A., Braun, J., Spahn, M. A., Aser, R., Spahn, D. R., & Wilhelm, M. J. (2023). Predictors associated with mortality of veno-venous extracorporeal membrane oxygenation therapy Journal of Thoracic Disease, 15, 2389–2401. https://doi.org/10.21037/jtd-22-1273
    • Werynska, K., Neumann, E., Cramer, T., Ganley, R. P., Gingras, J., & Zeilhofer, H. U. (2023). A phospho-deficient α3 glycine receptor mutation alters synaptic glycine and GABA release in mouse spinal dorsal horn neurons Journal of Physiology, 601, 4121–4133. https://doi.org/10.1113/JP284589

• 2022

  • Journal Article

    • Bhat, M. A., Esmaeili, A., Neumann, E., Balakrishnan, K., & Benke, D. (2022). Targeting the Interaction of GABA B Receptors With CHOP After an Ischemic Insult Restores Receptor Expression and Inhibits Progressive Neuronal Death Frontiers in Pharmacology, 13, 870861. https://doi.org/10.3389/fphar.2022.870861

• 2021

  • Journal Article

    • Werynska, K., Gingras, J., Benke, D., Scheurer, L., Neumann, E., & Zeilhofer, H. U. (2021). A Glra3 phosphodeficient mouse mutant establishes the critical role of protein kinase A-dependent phosphorylation and inhibition of glycine receptors in spinal inflammatory hyperalgesia Pain, 162, 2436–2445. https://doi.org/10.1097/j.pain.0000000000002236
    • Neumann, E., Küpfer, L., & Zeilhofer, H. U. (2021). The α2/α3GABAA receptor modulator TPA023B alleviates not only the sensory but also the tonic affective component of chronic pain in mice Pain, 162, 421–431. https://doi.org/10.1097/j.pain.0000000000002030

• 2020

  • Journal Article

    • Tudeau, L., Acuña, M. A., Albisetti, G. W., Neumann, E., Ralvenius, W. T., Scheurer, L., Poe, M., Cook, J. M., Johannssen, H. C., & Zeilhofer, H. U. (2020). Mice lacking spinal α2GABAA receptors: Altered GABAergic neurotransmission, diminished GABAergic antihyperalgesia, and potential compensatory mechanisms preventing a hyperalgesic phenotype Brain Research, 1741, 146889. https://doi.org/10.1016/j.brainres.2020.146889

• 2019

  • Journal Article

    • Zeilhofer, H. U., Neumann, E., & Munro, G. (2019). Spinal GABA receptors for pain control: back to the future? British Journal of Anaesthesia, 123, e176–e179. https://doi.org/10.1016/j.bja.2019.01.030
    • Neumann, E., Lepper, N., Vasile, M., Riccieri, V., Peters, M., Meier, F., Hülser, M.-L., Distler, O., Gay, S., Mahavadi, P., Günther, A., Roeb, E., Frommer, K. W., Diller, M., & Müller-Ladner, U. (2019). Adipokine expression in systemic sclerosis lung and gastrointestinal organ involvement Cytokine, 117, 41–49. https://doi.org/10.1016/j.cyto.2018.11.013

• 2018

  • Journal Article

    • Neumann, E., Ralvenius, W. T., Acuña, M. A., Rudolph, U., & Zeilhofer, H. U. (2018). TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABA receptors Neuropharmacology, 143, 71–78. https://doi.org/10.1016/j.neuropharm.2018.09.026
    • Ralvenius, W. T., Neumann, E., Pagani, M., Acuña, M. A., Wildner, H., Benke, D., Fischer, N., Rostaher, A., Schwager, S., Detmar, M., Frauenknecht, K., Aguzzi, A., Hubbs, J. L., Rudolph, U., Favrot, C., & Zeilhofer, H. U. (2018). Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors Nature Communications, 9, 3230. https://doi.org/10.1038/s41467-018-05709-0
    • Zeilhofer, H. U., Neumann, E., & Munro, G. (2018). Spinal GABAA receptors for pain control-Lost in translation? Pain, 159, 1675–1676. https://doi.org/10.1097/j.pain.0000000000001268
    • Klinger-Gratz, P. P., Ralvenius, W. T., Neumann, E., Kato, A., Nyilas, R., Lele, Z., Katona, I., & Zeilhofer, H. U. (2018). Acetaminophen relieves inflammatory pain through CB1 cannabinoid receptors in the rostral ventromedial medulla Journal of Neuroscience, 38, 322–334. https://doi.org/10.1523/JNEUROSCI.1945-17.2017

• 2012

  • Journal Article

    • Frommer, K. W., Schäffler, A., Büchler, C., Steinmeyer, J., Rickert, M., Rehart, S., Brentano, F., Gay, S., Müller-Ladner, U., & Neumann, E. (2012). Adiponectin isoforms: a potential therapeutic target in rheumatoid arthritis? Annals of the Rheumatic Diseases, 71, 1724–1732. https://doi.org/10.1136/annrheumdis-2011-200924
    • Meier, F. M. P., Frommer, K. W., Peters, M. A., Brentano, F., Lefèvre, S., Schröder, D., Kyburz, D., Steinmeyer, J., Rehart, S., Gay, S., Müller-Ladner, U., & Neumann, E. (2012). Visfatin/pre-B-cell colony-enhancing factor (PBEF), a proinflammatory and cell motility-changing factor in rheumatoid arthritis Journal of Biological Chemistry, 287, 28378–28385. https://doi.org/10.1074/jbc.M111.312884