Bach DR, Näf M, Deutschmann M, Tyagarajan SK, Quednow BB. Threat memory reminder under matrix metalloproteinase 9 inhibitor doxycycline globally reduces subsequent memory plasticity. J Neurosci. 2019 Oct 14. pii: 1285-19. doi: 10.1523/JNEUROSCI.1285-19.2019. [Epub ahead of print]

Brüning F, Noya SB, Bange T, Koutsouli S, Rudolph JD, Tyagarajan SK, Cox J, Mann M, Brown SA, Robles MS. Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science. 2019 Oct 11;366(6462). pii: eaav3617. doi: 10.1126/science.aav3617.

Noya SB, Colameo D, Brüning F, Spinnler A, Mircsof D, Opitz L, Mann M, Tyagarajan SK, Robles MS, Brown SA. The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science. 2019 Oct 11;366(6462). pii: eaav2642. doi: 10.1126/science.aav2642.


Campbell BFN, Tyagarajan SK. Cellular Mechanisms Contributing to the Functional Heterogeneity of GABAergic Synapses. Front Mol Neurosci. 2019 Aug 13;12:187. doi: 10.3389/fnmol.2019.00187. eCollection 2019.


Früh S, Tyagarajan SK, Campbell B, Bosshard G, Fritschy JM. The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal cultures. J Neurochem. 2018 Nov;147(4):477-494. doi: 10.1111/jnc.14572. Epub 2018 Nov 6.


Battaglia S, Renner M, Russeau M, Côme E, Tyagarajan SK, Lévi S. Activity-Dependent Inhibitory Synapse Scaling Is Determined by Gephyrin Phosphorylation and Subsequent Regulation of GABAA Receptor Diffusion. eNeuro. 2018 Jan 18;5(1). pii: ENEURO.0203-17.2017. doi: 10.1523/ENEURO.0203-17.2017. eCollection 2018 Jan-Feb


Fritschy JM, Tyagarajan SK. GABAergic Synaptogenesis: A Case for Cooperation. Neuron. 2017 Nov 15;96(4):709-711. doi: 10.1016/j.neuron.2017.11.003.


Wilkinson KA, Martin S, Tyagarajan SK, Arancio O, Craig TJ, Guo C, Fraser PE, Goldstein SAN, Henley JM. Commentary: Analysis of SUMO1-conjugation at synapses. Front Cell Neurosci. 2017 Oct 30;11:345. doi: 10.3389/fncel.2017.00345. eCollection 2017. No abstract available.


Maffei A, Charrier C, Caiati MD, Barberis A, Mahadevan V, Woodin MA, Tyagarajan SK. Emerging Mechanisms Underlying Dynamics of GABAergic Synapses. J Neurosci. 2017 Nov 8;37(45):10792-10799. doi: 10.1523/JNEUROSCI.1824-17.2017.


Mukherjee J, Cardarelli RA, Cantaut-Belarif Y, Deeb TZ, Srivastava DP, Tyagarajan SK, Pangalos MN, Triller A, Maguire J, Brandon NJ, Moss SJ. Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11763-11768. doi: 10.1073/pnas.1705075114. Epub 2017 Oct 16.


de Groot C, Floriou-Servou A, Tsai YC, Früh S, Kohler M, Parkin G, Schwerdel C, Bosshard G, Kaila K, Fritschy JM, Tyagarajan SK. RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors. PLoS Genet. 2017 Oct 25;13(10):e1007073. doi: 10.1371/journal.pgen.1007073. eCollection 2017 Oct.


Pennacchietti F, Vascon S, Nieus T, Rosillo C, Das S, Tyagarajan SK, Diaspro A, Del Bue A, Petrini EM, Barberis A, Cella Zanacchi F. Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation. J Neurosci. 2017 Feb 15;37(7):1747-1756. doi: 10.1523/JNEUROSCI.0514-16.2016.


Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, Acuña MA, Wildner H, Yévenes GE, Dieter A, Kawasaki H, O Hottiger M, Zeilhofer HU, Fritschy JM, Tyagarajan SK .Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission. Nat Commun. 2016 Nov 7;7:13365. doi: 10.1038/ncomms13365


Früh S, Romanos J, Panzanelli P, Bürgisser D, Tyagarajan SK, Campbell KP, Santello M, Fritschy JM. Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells. J Neurosci. 2016 Oct 5;36(40):10296-10313


Deprez F, Vogt F, Floriou-Servou A, Lafourcade C, Rudolph U, Tyagarajan SK, Fritschy JM Partial inactivation of GABAA receptors containing the α5 subunit affects the development of adult-born dentate gyrus granule cells.Eur J Neurosci. 2016 Sep;44(5):2258-71. doi: 10.1111/ejn.13329


Mircsof D, Langouët M, Rio M, Moutton S, Siquier-Pernet K, Bole-Feysot C, Cagnard N, Nitschke P, Gaspar L, Žnidarič M, Alibeu O, Fritz AK, Wolfer DP, Schröter A, Bosshard G, Rudin M, Koester C, Crestani F, Seebeck P, Boddaert N, Prescott K; DDD Study, Hines R, Moss SJ, Fritschy JM, Munnich A, Amiel J, Brown SA, Tyagarajan SK, Colleaux L. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects. Nat Neurosci. 2015 Nov 16. doi: 10.1038/nn.4169. [Epub ahead of print]


Deprez F, Pallotto M, Vogt F, Grabiec M, Virtanen MA, Tyagarajan SK, Panzanelli P, Fritschy JM. Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb. J Comp Neurol. 2015 Sep 1;523(13):1998-2016. doi: 10.1002/cne.23776.


Flores CE, Nikonenko I, Mendez P, Fritschy JM, Tyagarajan SK, Muller D. Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation. Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E65-72. doi: 10.1073/pnas.1411170112. Epub 2014 Dec 22


Accardi MV, Daniels BA, Brown PM, Fritschy JM, Tyagarajan SK, Bowie D. Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun. 2014 Jan 16;5:3168. doi: 10.1038/ncomms4168


Tyagarajan SK, Fritschy JM. Gephyrin: a master regulator of neuronal function? Nat Rev Neurosci. 2014 Feb 20;15(3):141-56. doi: 10.1038/nrn3670.


Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM. Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J Biol Chem. 2013 Apr 5;288(14):9634-47


Farinelli M, Heitz FD, Grewe BF, Tyagarajan SK, Helmchen F, Mansuy IM. Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection. PLoS One. 2012;7(3)


Fritschy JM, Panzanelli P, Tyagarajan SK. Molecular and functional heterogeneity of GABAergic synapses. Cell Mol Life Sci. 2012 Aug;69(15):2485-99.


Tyagarajan SK*, Ghosh H, Harvey RJ and Fritschy JM (2011), Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses. J Cell Sci. 2011 Aug 15;124 (Pt 16):2786-96.


Panzanelli P, Gunn BJ, Schlatter M, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JL, Rudolph U, Fritschy JM (2011). Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells. J Physiol. 589, 4959-4980 (2011)


Tyagarajan SK*, Ghosh H, Yévenes GE, Nikonenko I, Ebeling C, Schwerdel C, Sidler C, Zeilhofer HU, Gerrits B, Muller D, and Fritschy JM, Regulation of GABAergic synapse formation and plasticity by GSK3β-dependent phosphorylation of gephyrin. PNAS (USA) 108, 379-384 (2011).


Tyagarajan SK and Fritschy JM (2009), GABAARs, Gephyrin and Homeostatic synaptic plasticity. J. Physiol. 2009 Sept.


Bollag B, Kilpatrick LH, Tyagarajan SK, Tevethia MJ and Frisque RJ, JCV T’ proteins interact with p107 and p130 in vivo and promote transformation of Rat fibroblast cells. J. Neurovirol. 2006 Dec; 12(6): 428- 42).


Tyagarajan SK and Frisque RJ (2006), Phosphorylation of JC virus tumor proteins influences their interaction with p107 and p130 and the subsequent release of E2F. J Virol. 2006 March;80(5): 2083-91).


Frisque RJ, Hofstetter C, Tyagarajan SK (2006), Transforming activities of JC virus early proteins. Adv Exp Med Biol. 2006; 577:288-309.


Frisque RJ, Hofstetter C and Tyagarajan SK Transforming Activities of JC Virus Early Proteins- Book Chapter: Polyomavirus and Human Diseases, edited by Nasimul Ahsan ©2004


Frisque RJ, Bollag B, Tyagarajan SK, and Kilpatrick L (2003), T’ proteins influence JC virus biology; Journal of NeuroVirology, 9(suppl.-1): 15-20