Publications to the Animal Imaging Center (AIC)

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2006
Berger C, Hiestand P, Kindler-Baumann D, Rudin M, Rausch M (2006) Analysis of lesion development during acute inflammation and remission in a rat model of experimental autoimmune encephalomyelitisby visualization of macrophage infiltration, demyelination and blood-brain barrier damage. NMR Biomed 19: 101-7
Berger C, Rausch M, Rudin M (2006) Feasibility and limits of magnetically labeling primary cultured rat T cells with ferumoxides coupled with commonly used transfection agents. Molec Imaging 5: 95-104
2005
Rausch M, Gentsch C, Enz A, Baumann D, Rudin M (2005) Characterization of CNS drugs by mapping changes in regional CBV in the rat: a study paradigm allowing for automated comparison of three-dimensional data obtained multiple imaging sessions. NMR Biomed 18: 260-268
Hintersteiner M, Frey P, Gremlich HU, Kinzy W, Kneuer R, Neumann U, Rudin M, Staufenbiel M, Wiederhold KH (2005) In vivo detection of amyloid deposits by near-infrared fluorescence imaging using a novel oxazine derivative as contrast agent. Nature Biotechnology 23: 577-583
Rudin M, Allegrini PR, Baumann D, Bequet M, Brecht K, Ferretti S, Schaeffer F, Schnell C, Wood J, McSheehy P (2005) PTK787 / ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo. NMR Biomed 18: 308-321
Panizzutti R, Rausch M , Zurbrügg S , Baumann D , Beckmann N , Rudin M (2005) The Pharmacological Stimulation of NMDA Receptors Via Co-agonist Site: an fMRI Study in the Rat Brain. Neurosci Lett 380: 111-115
Markus TM, Tsai SY, Bollnow MR, Farrer RG, O’Brian TE, Kindler. Baumann DR, Rausch M, Rudin M, Wiessner C, Mir AK, Schwab ME, Kartje GL (2005) Recovery and Brain reorganization after stroke in adult and aged rats. Ann Neurol 58: 950-953
2004
Beckmannn, N., Laurent, D., Tigani, B., Panizzutti, R., Rudin, M. (2004) Magnetic resonance imaging in drug discovery: lessons from disease areas. Drug Disc Today 9: 35-42
Rudin, M., Beckmann, N., Rausch, M. (2004) MRI in biomedical research: imaging of drugs and drug effects. Meth Enzymol 385: 240-256
Beckmann N, Cannet C, Zurbruegg S, Rudin M, Tigani B (2004) Proton MRI of lung parenchyma reflects allergen-induced airway remodeling and endotoxin-aroused hyporesponsiveness: a step towards ventilation studies in spontaneously breathing rats. Magn Reson Med 52: 258-268
Rausch, M., Hiestand, P., Foster, C.A., Baumann, D., Cannet, C., Rudin, M. (2004) Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage-tracking: clinical implications for USPIO-enhanced magnetic resonance imaging. J Magn Reson Imaging 20: 16-24
Mueggler T, Meyer-Luehmann M, Rausch M, Staufenbiel M, Jucker M, Rudin M (2004) Restricted Diffusion in the Brain of Transgenic Mice with Cerebral Amyloidosis. Eur J Neurosci. 20:811-817
Rudin M, Rausch M, Stoeckli M. (2004) Molecular imaging in drug discovery and development: potential and limitations of non-nuclear methods. Mol Imag Biol 7: 5-13
Gremlich HU, Martínez V, Kneuer R, Kinzy W, Weber E, Pfannkuche HJ, Rudin M (2004) Noninvasive assessment gastric emptying by near-infrared fluorescence reflectance imaging (FRI) in mice: Pharmacological validation with tegaserod, cisapride and clonidine. Molec Imaging 3: 303-311
2003
Laurent, D, Wasvary, J., Rudin, M., O’Byrne, E, Pellas, T. (2003) In vivo assessment of proteoglycan content in articular cartilage of the goat knee. Magn.Reson.Med. 49: 1037-1046
Laurent D, Wasvary J, O'Byrne E, Rudin M (2003) In vivo qualitative assessments of articular cartilage in the rabbit knee with high-resolution MRI at 3T. Magn.Reson.Med. 50: 541-549
Rausch, M., Baumann, D., Cannet, C., Hiestand, P., Rudin, M. (2003) MRI based monitoring of inflammation and tissue damage in acute an chronic relapsing EAE. Magn.Reson.Med. 50: 309-314
Rudin, M., Weissleder, R. (2003) Molecular imaging in drug discovery and development. Nature Reviews Drug Discovery 3:123-131
Mueggler, T., Baumann, D., Rausch,M., Staufenbiel, M., Rudin, M. (2003) Age-dependent impairment of somatosensory response in the amyloid precursor protein 23 transgenic mouse model of Alzheimer’s disease. J.Neurosci. 23: 8231-8236
Rudin, M., Allegrini, P., Baumann, D., Mueggler, T., Rausch, M.(2003) Characterization of CNS disorders and evaluation of therapy using structural and functional MRI. Anal.Bioanal.Chem 377: 973-81
2002
Laurent, D., Poirier, K., Wasvary, J., Rudin, M. (2002) The effect of essential hypertension on kidney function as measured in rat by dynamic MRI. Magn.Reson.Med. 47: 127-134
Reese, T., Bochelen, D., Baumann, D., Rausch, M., Sauter, A., Rudin, M. (2002) Impaired functionality of reperfused brain tissue following short transient focal ischemia in rats. Magn.Reson.Imag. 20: 447-454
Sauter, A., Reese, T., Pórszász, R., Baumann, D., Rausch ,M., Rudin, M. (2002) Recovery of function in cytoprotected cerebral cortex in rat stroke model assessed by functional MRI. Magn Reson Med 47:759-765
Rausch, M., Sauter, A., Baumann, D., Neubacher, U., Rudin, M. (2002) In-Vivo visualization of phagocytotic cells in rat brains after transient ischemia by USPIO. NMR Biomed 15: 278-283
Mueggler, T., Sturchler-Pierrat, C., Baumann, D., Rausch,M., Staufenbiel, M., Rudin, M. (2002) Compromised hemodynamic response in amyloid precursor protein transgenic mice. J.Neuroscience 15: 7218-7224
Bahr, B.A., Bendiske, J., Brown, Q.B., Munirathiman, S., Caba, E., Rudin, M., Urwyler, S., Sauter, A., Rogers, G. (2002) Survival signalling and selective neuroprotection through glutamergic transmission. Exp Neurol 174: 37-47
Hughes, P.M., Allegrini, P.R., Rudin, M., Perry, V.H., Mir, A.K., Wiessner C. (2002) Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model. J Cerebr Blood Flow Metabol 22: 308-317

Book

Rudin M (2005) Molecular Imaging – Basic principles and Applications in Biomedical Research. Imperial College Press (London) , ISBN 1-86094-528-7