Publications Therapeutic Neuroscience; Prof. H. Möhler

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Möhler, H. Molecular regulation of cognitive functions and developmental plasticity: impact of GABA-A receptors. J. Neurochem. 102,1-12 (2007)  
Earnheart, JC., Schweizer, C., Crestani, F., Iwasato, T., Itohara, S., Möhler, H., Lüscher, B. GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. J. Neurosci. 27, 3845-3854 (2007)  
Möhler, H. GABA-A receptor diversity and pharmacology. Cell Tissue Res. 326, 505-516 (2006)  
Yee, B., Balic, E., Singer, Ph., Schwerdel, C., Grampp, Th., Gabernet, L., Knuesel, I., Benke, D., Feldon, J., Möhler, H., Boison, D. Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a pro-cognitive and anti-psychotic phenotypic profile. J. Neuroscience 26, 3169-81 (2006)  
Rudolph, U. and Möhler H. GABA-based therapeutic approaches: GABA-A receptor subtype functions. Curr. Opin. Pharmacol. 6, 18-23 (2006)  
Yee, B., Keist, R., von Boehmer, L., Studer, R., Benke, D., Hagenbuch, N., Dong, Y., Malenka, RC., Fritschy, JM., Bluethmann, H., Feldon, J., Möhler, H., Rudolph, U. A schizophrenia-related sensorimotor deficit links α3- containing GABAA receptors to a dopamine hyperfunction. Proc. Nat. Acad. Sci. USA 102, 17154-17159 (2005)  
Fagiolini, M., Fritschy, J.M., Löw, K., Möhler, H., Rudolph, U. and Hensch, T.K. Specific GABAA circuits for visual cortical plasticity. Science 303, 1681-1683 (2004) (reviewed in Science 303, 1619-1621, 2004)  
Rudolph, U. and Möhler, H. Analysis of GABAA receptor function and dissection of pharmacology of benzodiazepines and general anesthetics through mouse genetics. Ann. Rev. Pharmacol. Toxicol. pp. 475-498 (2004)  
Crestani F., Keist, R., Fritschy, J.M., Benke, D., Vogt, K., Prut, L., Blüthmann, H., Möhler, H. and Rudolph, U. Trace fear conditioning involves hippocampal α5GABAA receptors. Proc. Nat. Acad. Sci USA 99, 8980-8985 (2002)  
Möhler, H., Fritschy, J.-M. and Rudolph U. Perspectives in pharmacology: a new benzodiazepine pharmacology. J. Pharmacol. Exp. Ther. 300, 2-8 (2002)  
Huber, A., Padrun, V., Deglon, N., Aebischer, P., Möhler, H. and Boison, D. Grafts of adenosine releasing cells suppress seizures in kindling epilepsy. Proc. Natl. Acad. Sci. USA 98, 7611-7616 (2001) (reviewed in TRENDS in Molecular Medicine 7, 338,2001)  
Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J.A., Fritschy, J.M., Rülicke, Th., Bluethmann, H., Möhler, H., and Rudolph, U. Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290, 131-134 (2000) (reviewed in News of the Week, Science 290, 23-25, 2000 and New England J. Med. 344, 1247-1249, 2001)  
Rudolph, U., Crestani, F., Benke, D., Brünig, I., Benson, J.A., Fritschy, JM., Martin, J.R., Blüthmann, H. and Möhler, H. Benzodiazepine actions mediated by specific γ-aminobutyric acidA receptor subtypes. Nature 401, 796-800 (1999) (reviewed in Nature 401, 751-752, 1999 and The Lancet 354, 1451, 1999)  
Crestani, F., Lorez, M., Baer, K., Essrich, Ch., Benke, D., Laurent, J.P. Belzung, C., Fritschy, J.-M., Lüscher, B. and Möhler, H. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Nature Neurosci. 2, 833-839 (1999) (reviewed in Nature Neurosci. 2, 780-782, 1999 and Nature Medicine 5, 1131-1132, 1999)  

 

Earlier classical publications

Möhler, H., Okada, T. Benzodiazepine receptor: demonstration in the central nervous system. Science 198, 849-851 (1977)  
Hunkeler, W., Möhler, H. et al. Selective antagonists of benzodiazepines. Nature 290, 514-516 (1981)  
Schoch, P., Richards, J.G., Häring, P., Takacs, B., Stähli, C., Staehelin, T., Haefely, W. and Möhler, H. Co-localization of GABAA-receptors and benzodiazepine receptors in the brain shown by monoclonal antibodies. Nature 314, 168-171 (1985)  
Fritschy, J.M., Benke, D., Mertens, S., Oertel, W.H., Bachi, T. and Möhler, H. Five GABAA-receptor subtypes identified in neurons by double and triple immunofluorescence staining with subunit specific antibodies. Proc.Natl.Acad.Sci. USA 89, 6726-6730 (1992)