Albisetti GW, Pagani M, Platonova E, Hösli L, Johannssen HC, Fritschy JM, Wildner H, Zeilhofer HU. Dorsal Horn Gastrin-Releasing Peptide Expressing Neurons Transmit Spinal Itch But Not Pain Signals. J Neurosci. 2019 Jan 17. pii: 2559-18. doi: 10.1523/JNEUROSCI.2559-18.2019.


Früh S, Tyagarajan SK, Campbell B, Bosshard G, Fritschy JM. The catalytic function of the gephyrin-binding protein IQSEC3 regulates neurotransmitter-specific matching of pre- and post-synaptic structures in primary hippocampal cultures. J Neurochem. 2018 Nov;147(4):477-494. doi: 10.1111/jnc.14572. Epub 2018 Nov 6.

Hines RM, Maric HM, Hines DJ, Modgil A, Panzanelli P, Nakamura Y, Nathanson AJ, Cross A, Deeb T, Brandon NJ, Davies P, Fritschy JM, Schindelin H, Moss SJ. Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin. Nat Commun. 2018 Aug 7;9(1):3130. doi: 10.1038/s41467-018-05481-1.

Gschwind T, Lafourcade C, Gfeller T, Zaichuk M, Rambousek L, Knuesel I, Fritschy JM. Contribution of early Alzheimer's disease-related pathophysiology to the development of acquired epilepsy. Eur J Neurosci. 2018 Jun;47(12):1534-1562. doi: 10.1111/ejn.13983. Epub 2018 Jun 19.


Fritschy JM, Tyagarajan SK.GABAergic Synaptogenesis: A Case for Cooperation. Neuron. 2017 Nov 15;96(4):709-711. doi: 10.1016/j.neuron.2017.11.003.

de Groot C, Floriou-Servou A, Tsai YC, Früh S, Kohler M, Parkin G, Schwerdel C, Bosshard G, Kaila K, Fritschy JM, Tyagarajan SK. RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors. PLoS Genet. 2017 Oct 25;13(10):e1007073. doi: 10.1371/journal.pgen. 1007073. eCollection 2017 Oct.

Panzanelli P, Früh S, Fritschy JM.Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus. Brain Struct Funct. 2017 Dec;222(9):4149-4161. doi: 10.1007/s00429-017-1462-7. Epub 2017 Jun 22.

Fritschy JM, Sarter M.The European Journal of Neuroscience from 2008 to 2014. Eur J Neurosci. 2017 Apr;45(7):875-876. doi: 10.1111/ejn.13531. Epub 2017 Feb 19. 

Bode C, Richter F, Spröte C, Brigadski T, Bauer A, Fietz S, Fritschy JM, Richter A. Altered postnatal maturation of striatal GABAergic interneurons in a phenotypic animal model of dystonia. Exp Neurol. 2017 Jan;287(Pt 1):44-53. doi: 10.1016/j.expneurol.2016.10.013. Epub 2016 Oct 22.


Früh S., Romanos J., Panzanelli P., Bürgisser D., Tyagarajan S.K., Campbell Kevin P., Santello M., and Fritschy J.-M. Neuronal dystroglycan is necessary for formation and maintenance of functional CCK-positive basket terminals on pyramidal cells. J. Neurosci., in print.

Deprez F., Vogt F., Floriou-Servou A., Lafourcade C., Rudolph U., Tyagarajan S.K. and Fritschy J.-M., Partial inactivation of GABAA receptors containing the a5 subunit affects the development of adult-born dentate gyrus granule cells. Eur. J. Neurosci., in print (2016).

Engin E., Smith K.S., Gao Y., Nagy D., Foster R.A., Tsvetkov E., Keist R., Crestani F., Fritschy J.-M., Bolshakov V.Y., Hajos M., Heldt S.A., and Rudolph U. Modulation of anxiety and fear via distinct intrahippocampal circuits. Elife. 2016 Mar 14;5. pii: e14120 (2016).

Rambousek L.,  Kleteckova L., Kubesova A., Jirak D., Vales K., and Fritschy J.-M., Rat intra-hippocampal NMDA infusion induces cell-specific damage and changes in expression of NMDA and GABAA receptor subunits. Neuropharmacology 105, 594-606 (2016).


Mircsof D., Langouët M., Rio M., Moutton S., Siquier-Pernet K., Bole-Feysot C., Cagnard N., Nitschke P., Gaspar L., Žnidarič M., Fritz A.K., Wolfer D.P., Schröter A., Bosshard G., Rudin M., Koester C., Crestani F., Seebeck P., Boddaert N., Fritschy J.-M., Munnich A., Amiel  J., Brown S.A., Tyagarajan S.K., and Colleaux L. NONO mutations cause syndromic intellectual disability and inhibitory synaptic defects. Nature Neurosci. 18, 1731-1736 (2015).

Angliker N., Burri M., Zaichuk M., Fritschy J.-M., and Rüegg M.A. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. Eur. J. Neurosci. 42, 2595-2612 (2015).

Hofer S.C., Ralvenius W.T., Gachet M.S. Fritschy J.-M., Zeilhofer H.U., and Gertsch J. Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla. Neuropharmacology 98, 78-89 (2015).

He Q., Duguid I., Clark B, Panzanelli P., Patel B., Thomas P., Fritschy J.-M., and Smart T.G. Interneuron- and GABAA receptor-specific inhibitory synaptic plasticity. Nature Comm. 16, 6:7364 (2015).

Deprez F., Pallotto M., Vogt F., Grabiec M., Virtanen M.A, Tyagarajan S.K., Panzanelli P., and Fritschy J.-M. Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb. J. Comp. Neurol. 523, 1998-2016 (2015).

Flores C.E., Nikonenko I., Mendez P., Fritschy J.-M., Tyagarajan S.K.*, and Muller D. Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation. Proc. Natl. Acad. Sci. USA 112, E65-72 (2015).

Pfister S., Weber T., Härtig W., Schwerdel C., Elsaesser R., Knuesel I., and Fritschy J.-M. A novel role of CFTR in maintaining adult mouse olfactory neuronal homeostasis. J. Comp. Neurol. 526, 406-430 (2015).


Antonelli R., Pizzarelli R., Pedroni A., Fritschy J.-M., Del Sal G, Cherubini E., and Zacchi P.
Pin1-dependent signaling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction. Nature Comm. 5, 5066 (2014).

Accardi M.V., Daniels B.A., Brown P.M.W.G., Fritschy J.M., Tyagarajan S.K. and Bowie D. Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nature Comm. 5, 3168 (2014).

Notter T.*, Panzanelli P.*, Pfister S., Mircsof D., and Fritschy J.-M. A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse CNS. Eur. J. Neurosci. 39, 165-175 (2014). *Equal contribution

Paul J., Yévenes G., Benke D., Di Lio A., Ralvenius W., Witschi R., Scheurer L., Cook J., Rudolph U., Fritschy J.-M., and Zeilhofer H.U. Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. Neuropharmacology 39, 477-487 (2014).


Calcinaghi N., Wyss M.T., Jolivet R., Singh A., Keller A.L., Winnik S., Fritschy J.-M., Buck A., Matter C.M., and Weber B. Multimodal imaging reveals impaired neurovascular coupling in sustained hypertension. Stroke, 44,1957-1964 (2013)

Tyagarajan S.K., Ghosh H., E. Yévenes G.E., Imanishi SY, Zeilhofer H.U., Gerrits B., and Fritschy J.-M. ERK and GSK3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J. Biol. Chem. 288, 9634-9647 (2013)

Straub C.J., Lau H.,  Parlato R., Schuetz G., Fritschy J.-M., and Rudolph U. Bidirectional regulation of intravenous general anesthetic actions by α3-containing GABAA receptors. J. Anesthesiol., 118, 562-576 (2013)

Aguado C., Fernández-Alacid L., Cabañero M.J., Yanagawa Y., Schilling K., Watanabe M., Fritschy J.-M., and Luján R. Differential maturation of GIRK2-expressing neurons in the mouse cerebellum. J. Chem. Neuroanat, 47, 79-89 (2013)

Koester C., Rudolph U., Haenggi T., Papilloud A., Fritschy J.-M., and Crestani F. Dissecting the role of γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat. Pharmacol. Biochem. Behav. 103, 541-549 (2013).


Marowsky A., Rudolph U., Fritschy J.-M., and Arand M. Tonic inhibition in the basolateral amygdala is mediated by a3 subunit-containing GABAA receptors. J. Neurosci. 32, 611-619 (2012).

Pallotto M., Nissant A., Fritschy J.-M., Rudolph U., Sassoè-Pognetto M., Panzanelli P., and Lledo P.M. Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. J. Neurosci. 32, 9103-9115 (2012).

Pfister S., Dietrich M.G., Sidler C., Fritschy J.-M, Knuesel I., Elsaesser R. Characterization and turnover of CD73/IP3R3-positive microvillar cells in the adult mouse olfactory epithelium. Chem. Senses, 37, 859-868 (2012).

Paul J., Zeilhofer H.U., and Fritschy J.-M. Selective distribution of GABAA receptor subtypes in mouse spinal dorsal horn neurons and primary afferents. J. Comp. Neurol. 520, 3895-3911 (2012).


Panzanelli P., Gunn B.G., Schlatter M., Benke D., Tyagarajan S.K., Scheiffele P., Belelli D., Lambert J.J., Rudolph U., and Fritschy J.-M. Dystrophin anchors a1-GABAA receptors in perisomatic GABAergic synapses of hippocampal pyramidal cells. J. Physiol. 589, 4959-4980 (2011).

Duveau V., Madhusudan A., Caleo M., Knuesel I., and Fritschy J.-M. Impaired reelin processing and secretion by Cajal-Retzius cells contributes to the development of granule cell dispersion in a mouse model of temporal lobe epilepsy. Hippocampus 21, 935–944 (2011).

Deprez F., Zattoni M., Mura M. L., Frei K., and Fritschy J.-M. Adoptive transfer of T lymphocytes in immunodeficient mice influences epileptogenesis and neurodegeneration in a model of temporal lobe epilepsy. Neurobiol. Disease 44, 174-184 (2011).

Tyagarajan S.K., Ghosh H., Harvey K., and Fritschy J.-M. Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses. J. Cell Sci. 124, 2786-2796 (2011).

Duveau V., Laustela S., Gianolini F., Barth L., Vogt K.E., Keist R., Chandra D., Homanics G.E., Rudolph U., and Fritschy J.-M. Spatio-temporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. Eur. J. Neurosci. 34, 362-373 (2011).

Witschi R., Punnakkal P., Paul J., Walczak J.S., Cervero F., Fritschy J.-M., Kuner R., Keist R., Rudolph U., Zeilhofer H.U. Presynaptic a2-GABAA receptors in primary afferent depolarization and spinal pain control. J. Neurosci. 31, 8134-8142 (2011).

Lachos J., Zattoni M., Wieser H.G., Fritschy J.-M., Langmann T., Schmitz G., Errede M., Virgintino D., Yonekawa Y., and Frei K. Characterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. Epil. Res. Treatment, Art. ID 758407, 11 pages (2011); doi:10.1155/2011/758407.

Tyagarajan S.K., Ghosh H., Yévenes G.E., Nikonenko I., Ebeling C., Schwerdel C., Sidler C., Zeilhofer H.U., Gerrits B., Muller D., and Fritschy J.-M. Regulation of GABAergic synapse formation and plasticity by GSK3b-dependent phosphorylation of gephyrin. Proc. Natl. Acad. Sci. (USA) 108, 379-384 (2011).

Zattoni M., Mura M.L., Deprez F., Schwendener R.A., Engelhardt B., Frei K., and Fritschy J.-M. Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J. Neurosci 31, 4037-4050  (2011).


Fritschy JM. Significance of GABAA receptor heterogeneity: clues from developing neurons. Adv Pharmacol. 73:13-39 (2015)

Fritschy J.-M. and Panzanelli P. GABAA receptors and plasticity of inhibitory neurotransmission in the CNS. Eur. J. Neurosci. 39, 1845-1865 (2014).

Tyagarajan S.K. and Fritschy J.-M. Gephyrin, a master regulator of neuronal function? Nature Neurosci. Rev., 15, 141-156 (2014).

Fritschy J.-M., Panzanelli P., and Tyagarajan S.K. Molecular and functional heterogeneity of GABAergic synapses. Cell. Mol. Life Sci., 69, 2485-2499 (2012).


Fritschy J.-M. & Panzanelli P. Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation. In “Extrasynaptic GABAA receptors” (Errington A., Crunelli V., eds.) Springer, in press (2014).

Möhler H, Benke D, Rudolph U, Fritschy J.-M. GABAA receptors.  In: "Ion Channels, From Structure to Function" (Kew J. and Davies C., eds.) Oxford University Press, Oxford, pp 263 - 276 (2010).