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Ben Collins, Sara Pierre-Ferrer, Christine Muheim, David Lukacsovich, Yuchen Cai, Andrea Spinnler, Carolina Gutierrez Herrera, Shao'Ang Wen, Jochen Winterer, Mino D C Belle, Hugh D Piggins, Michael Hastings, Andrew Loudon , Jun Yan, Csaba Földy, Antoine Adamantidis , Steven A Brown Circadian VIPergic Neurons of the Suprachiasmatic Nuclei Sculpt the Sleep-Wake Cycle Neuron. 2020 Aug 26;S0896-6273(20)30608-5. doi: 10.1016/j.neuron.2020.08.001. Online ahead of print.


Mirjam Münch, Anna Wirz-Justice, Steven A. Brown, Thomas Kantermann, Klaus Martiny, Oliver Stefani, Céline Vetter, Kenneth P. Wright Jr, Katharina Wulff, Debra J. Skene The Role of Daylight for Humans: Gaps in Current Knowledge Clocks & Sleep 2020, 2, 61–85; doi:10.3390/clockssleep2010008


Steven A. Brown, Miho Sato Marching to another clock: Robust daily rhythms of RNA and protein expression occur in “clockless” cells  Science 2020 Feb 14; 367 (6479) 740-741; doi: 10.1126/science.aba5336


Franziska Brüning*, Sara B. Noya*, Tanja Bange, Stella Koutsouli, Jan D. Rudolph, Shiva K. Tyagarajan, Jürgen Cox, Matthias Mann, Steven A. Brown§, Maria S. Robles§ Sleep-wake cycles drive daily dynamics of synaptic phosphorylation. Science 2019 Oct 11;366(6462). pii: eaav3617. doi: 10.1126/science.aav3617.

§ shared senior authorship


Sara B. Noya, David Colameo, Franziska Brüning, Andrea Spinnler, Dennis Mircsof, Lennart Opitz, Matthias Mann, Shiva K. Tyagarajan§, Maria S. Robles§, Steven A. Brown§ The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep. Science 2019 Oct 11;366(6462). pii: eaav2642. doi: 10.1126/science.aav2642.

§ shared senior authorship


Muheim CM, Spinnler A, Sartorius T, Dürr R, Huber R, Kabagema C, Ruth P, Brown SA  Dynamic- and Frequency-Specific Regulation of Sleep Oscillations by Cortical Potassium Channels. Curr Biol. 2019 Sep 23;29(18):2983-2992.e3. doi: 10.1016/j.cub.2019.07.056. Epub 2019 Aug 29.


Sinturel F, Makhlouf AM, Meyer P, Tran C, Pataky Z, Golay A, Rey G, Howald C, Dermitzakis ET, Pichard C, Philippe J, Brown SA, Dibner C Cellular Circadian Period Length Inversely Correlates with HbA1c Levels in Individuals with Type 2 Diabetes Diabetologia, 2019 Aug;62(8):1453-1462. Epub 2019 May 27.






Benegiamo G, Mure LS, Erikson G, Le HD, Moriggi E, Brown SA§, and Panda S§ The RNA-Binding Protein NONO Coordinates Hepatic Adaptation to Feeding. Cell Metab. 2018 Feb 6; 27(2): 404-418.e7.

§ shared senior authorship


Schmitt K, Grimm A, Dallmann R, Oettinghous B, Restelli LM, Witzig M, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S, Brown SA§, Eckert A§. Circadian Control of DRP 1 Activity Regulates Mitochondrial Dynamics and Bioenergetics. Cell Metab. 2018 Mar 6;27(3):657-666.e5

§ shared senior authorship


Gaspar L, Howald C, Popadin K, Maier B, Mauvoisin D, Moriggi E, Gutierrez-Arcelus M, Falconnet E, Borel C, Kunz D, Kramer A, Gachon F, Dermitzakis ET, Antonarakis SE, and Brown SA The genomic landscape of human cellular circadian variation points to a novel role for the signalosome. Elife 2017 Sep 4;6 (2017)

Azzi, A., Evans, J.A., Leise, T., Myung, J., Takumi, T., Davidson, A.J., and Brown, S.A Network dynamics mediate circadian clock plasticity. Neuron, Neuron 2017 Jan 18;93(2):441-450 (2017) DOWNLOAD (PDF, 3 MB)

Jansen HT, Leise T, Stenhouse G, Pigeon K, Kasworm W, Teisberg J, Radandt T, Dallmann R, Brown S, Robbins CT. The bear circadian clock doesn't 'sleep' during winter dormancy.  Front Zool. Sep 17;13:42 (2016)

Mircsof D, Langouët M, Rio M, Moutton S, Siquier-Pernet K, Bole-Feysot C, Cagnard N, Nitschke P, Gaspar L, Žnidarič M, Alibeu O, Fritz AK, Wolfer DP, Schröter A, Bosshard G, Rudin M, Koester C, Crestani F, Seebeck P, Boddaert N, Prescott K; DDD Study, Hines R, Moss SJ, Fritschy JM, Munnich A, Amiel J, Brown SA, Tyagarajan SK and Colleaux L. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects. Nat Neurosci. Dec;18(12):1731-6. (2015)
Drägert K, Bhattacharya I, Pellegrini G, Seebeck P, Azzi A, Brown SA, Georgiopoulou S, Held U, Blyszczuk P, Arras M, Humar R, Hall MN, Battegay E and Haas E. Deletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure. Hypertension. Aug;66(2):332-9. (2015)
Li X, Martinez-Lozano Sinues P, Dallmann R, Bregy L, Hollmén M, Proulx S, Brown SA, Detmar M, Kohler M and Zenobi R. Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath. Angew Chem Int Ed Engl. Jun 26;54(27):7815-8. (2015)
Saini C, Brown SA and Dibner C. Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology. Front Neurol. May 13;6:95. (2015)
Gaspar L and Brown SA. Measuring circadian clock function in human cells. Methods Enzymol. 552:231-56. (2015)
Azzi A, Dallmann R, Casserly A, Rehrauer H, Patrignani A, Maier B, Kramer A, and Brown SA. Circadian behavior is light-reprogrammed by plastic DNA methylation. Nat Neurosci. 17:377-82. (2014)
Gaspar L, van de Werken M, Johansson A-S, Moriggi E, Owe-Larsson B, Kocks JWH, Lundkvist GB, Gordijn MCM and Brown SA. Human cellular differences in cAMP - CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder. Eur J Neurosci. 40:2206–2215. (2014)
Martinez-Lozano Sinues P, Tarokh L, Li X, Kohler M, Brown SA, Zenobi R and Dallmann R. Circadian variation of the Human metabolome captured by real-time breath analysis. PLoS One 9(12):e114422. (2014)
Kowalska E, Ripperger JA, Hoegger DC, Bruegger P, Buch T, Birchler T, Mueller A, Albrecht U, Contaldo C, and Brown SA. NONO couples the circadian clock to the cell cycle. Proc Natl Acad Sci USA 110:1592-9. (2013)
Kowalska E, Ripperger JA, Muheim C, Maier B, Kurihara Y, Fox AH, Kramer A, and Brown SA. Distinct roles of DBHS family members in the circadian transcriptional feedback loop. Mol Cell Biol. 32:4585-94. (2012)
Dallmann R, Viola AU, Tarokh L, Cajochen C, and Brown SA. The human circadian metabolome. Proc. Natl Acad Sci USA, 109(7):2625-9. (2012)
Pagani L, Schmitt K, Meier F, Izakovic J, Roemer K, Viola A, Cajochen C, Wirz-Justice A, Brown SA, and Eckert A. Serum factors in older individuals change cellular clock properties. Proc. Natl Acad Sci USA, 108(17):7218-7223. (2011)
Pagani L, Semenova EA, Moriggi E, Revell VL, Hack LM, Lockley SW, Arendt J, Skene DJ, Meier F, Izakovic J, Wirz-Justice A, Cajochen C, Sergeeva OJ, Cheresiz SV, Danilenko KV, Eckert A, and Brown SA. The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS ONE, 5(10):E13376. (2010)
Kowalska E, Moriggi E, Bauer C, Dibner C, and Brown SA. The circadian clock starts ticking at a developmentally early stage. J Biol Rhythms 25, 442-9. (2010)
Brown SA*, Kunz D, Dumas A, Westermark PO, Vanselow K, Tilmann-Wahnschaffe A, Herzel H, Kramer A. Molecular insights into human daily behavior. Proc. Natl. Acad Sci USA 105:1602-1607. (*corresponding authorship), (2008)
Brown SA, Ripperger J, Kadener S, Fleury-Olela F, Vilbois F, Rosbash M, Schibler U. PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science 308: 693-696. (2005)
Brown SA, Fleury-Olela F, Nagoshi E, Hauser C, Juge C A, Meier CA, Chicheportiche R, Dayer JM, Albrecht U, and Schibler U. The period length of fibroblast circadian gene expression varies widely among human individuals.PLoS Biology 3, e338. (2005) 
He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, and Calderwood SK. Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. J Biol Chem 278: 35465-75.
Brown SA, Zumbrunn G, Fleury-Olela F, Preitner N, and Schibler U. Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol. 12:1574-1583. (2002)
Balsalobre A, Brown SA, Marcacci L, Tronche F, Kellendonk C, Reichardt HM, Schutz G, and Schibler U. Resetting of circadian time in peripheral tissues by glucocorticoid signalling. Science 289:2344-2347. (2000)
Brown SA, Weirich CS, Newton EM, and Kingston RE. Transcriptional activation domains stimulate initiation and elongation at different times and via different residues. EMBO J. 17:3146-3154. (1998)
Brown SA and Kingston RE. Disruption of downstream chromatin directed by a transcriptional activator. Genes Dev. 11:3116-3121. (1997)
Brown SA, Imbalzano AN, and Kingston RE. Activator-dependent regulation of transcriptional pausing on chromatin templates. Genes Dev. 10:1479-1490. (1996)
Hirschhorn JN, Brown SA, Clark CD, and Winston F. Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure. Genes Dev. 6:2288-2298. (1992)



Cederroth CR, Albrecht U, Bass J, Brown SA, Dyhrfjeld-Johnsen J, Gachon F, Green CB, Hastings MH, Helfrich-Förster C, Hogenesch JB, Lévi F, Loudon A, Lundkvist GB, Meijer JH, Rosbash M, Takahashi JS, Young M, Canlon B Medicine in the Fourth Dimension Cell Metab 2019 Aug 6;30(2):238-250.


Bach Dominik R , Brown Steven A , Kleim Birgitad , Tyagarajan Shiva K. Review: Extracellular matrix: a new player in memory maintenance and psychiatric disorders. Swiss Med Wkly. 2019 Jun 2;149:w20060. doi: 10.4414/smw.2019.20060. eCollection 2019 May 20.


Huges ME, Abruzzi KC, Allanda R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-PedersenD, Blau J, Brown SA, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfiled D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptácek, LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB The Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms. 2017 Oct;32(5):380-393


Brown SA. Circadian Metabolism: From Mechanisms to Metabolomics and Medicine. Trends Endocrinol Metab. Jun;27(6):415-26. (2016)


Langouët M, Mircsof D, Rio M, Amiel J, Brown SA, Colleaux L. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects Med Sci (Paris). Jun-Jul;32(6-7):571-3 (2016)


Benegiamo G, Brown SA, Panda S. RNA Dynamics in the Control of Circadian Rhythm. Adv Exp Med Biol. 907:107-22 (2016)


Gaspar L, Brown SA. Measuring circadian clock function in human cells. Methods Enzymol. 552:231-56 (2015)


Saini C, Brown SA, Dibner C. Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology. Front Neurol. May 13;6:95 (2015)


Bassetti CL, Ferini-Strambi L, Brown S, Adamantidis A, Benedetti F, Bruni O, Cajochen C, Dolenc-Groselj L, Ferri R, Gais S, Huber R, Khatami R, Lammers GJ, Luppi PH, Manconi M, Nissen C, Nobili L, Peigneux P, Pollmächer T, Randerath W, Riemann D, Santamaria J, Schindler K, Tafti M, Van Someren E, Wetter TC. Neurology and psychiatry: waking up to opportunities of sleep. : State of the art and clinical/research priorities for the next decade. Eur J Neurol. Oct;22(10):1337-54 (2015)

Brown SA. Circadian clock-mediated control of stem cell division and differentiation: beyond night and day. Development, 141(16):3105-11 (2014)
Dallmann R, Brown SA, and Gachon F. Chronopharmacology: New Insights and Therapeutic Implications. Ann Rev Pharmacol Toxicol, 54:339-361. (2014)
Brown SA and Azzi A. Peripheral Circadian Oscillators in Mammals. Handb. Exp. Pharmacology, 217:45-66. (2013)
Mircsof D and Brown SA. The influence of light, exercise, and behavior upon circadian rhythms. In: Kushida C. (ed.) The Encyclopedia of Sleep, 1:435-441. (2013)
Muheim C and Brown SA. Adenosine and Other Purinergic Products in Circadian Timing. In S. Masino and D. Boison (eds.), Adenosine: A Key Link between 213 Metabolism and Brain Activity, pp. 212-223. (2013)
Brown SA, Kowalska E, and Dallmann R. (Re)inventing the circadian feedback loop. Dev Cell, 13; 22(3):477-87 (2012)
Brown SA. Circadian rhythms. A new histone code for clocks? Science 333, 1833-4. (2011)
Brown SA, Schmidt K, and Eckert A. Aging and Circadian Disruption: Causes and Effects.Aging, August, Vol. 3, No. 8. (2011)
Brown SA, Pagani L, Cajochen C, and Eckert A. Systemic and cellular reflections on ageing and the circadian oscillator - A mini-review. Gerontology, 57(5):427-434. (2011)
Pagani L, Eckert A, Brown SA. Studying human circadian bevaviour using peripheral cells. In: Clelland JD. Genomics, Proteomics and the Nervous System. New York, 729-302. (2011) Verlag

Albrecht U.The Circadian Clock. New York, Vol. 12, 2010

Rippberger JA, Brown SA. Transcriptional regulation of circadian clocks. In: Albrecht U. The Circadian Clock. New York, Vol. 12, 2:37-78. (2010) Verlag
Brown SA, Pagani L, Cajochen C, Eckert A. Systemic and cellular reflections on ageing and the circadian oscillator - A mini-review. Gerontology, 57(5):427-434. (2010)
Cuninkova L, Brown SA. Peripheral Circadian Oscillators: Interesting mechanisms and powerful tools. Annals NY. Acad Sci 1129:358-370. (2008) 
Kowalska E and Brown SA. Peripheral clocks: keeping up with the mater clock. Cold Spring Harb Symp Quant Biol 72:301-5. (2007) .
Brown SA, Schibler U. Les rythmes circadiennes – dans le peau. Medecine et Science, 22:474-5. (2006)
Schibler U and Brown SA. Enlightening the adrenal gland. Cell Metab. 2:278-81. (2005)
Nagoshi E, Brown SA, Dibner C, Kornmann B, and Schibler U. Circadian gene expression in cultured cells. Methods Enzymol. 393:543-57. (2005)
Gachon F, Nagoshi E, Brown SA, Ripperger J, Schibler U. The mammalian circadian timing system: from gene expression to physiology. Chromosoma  113:103-12. (2004)
Preitner N, Brown SA, Ripperger J, Le-Minh N, Damiola F, and Schibler U. Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators. Novartis Found Symp 253:89-99; discussion: 99-109. (2003)
Schibler U, Ripperger J, Brown SA. Peripheral circadian oscillators in mammals: time and food. J. Biol. Rhythms 18:250-260. (2003)
Schibler U, Brown SA, and Ripperger J. The mammalian circadian timing system. In the Handbook of Cell Signaling, Elsevier Science, USA, Volume 3:139-143. (2003)
Schibler U, Ripperger J, Brown SA. Chronobiology -- reducing time. Science 293:437-438. (2001) 
Brown SA and Schibler U. Circadian rhythms: mop up the clock! Curr Biol. 11:R268-270. (2001) 
Brown SA, Schibler U. The ins and outs of circadian timekeeping.Curr Opin Genet Dev. 9:588-594. (1999)