Prof. Dr. med. Alexander Borbély
|Institute of Pharmacology
University of Zurich
Tel. (0041) 44 635 5960
Fax (0041) 44 635 5707
Main Goals, Keywords
Sleep regulation, circadian rhythm, EEG analysis, brain mapping, molecular
genetic analysis of sleep, modeling of sleep and circadian rhythmicity. Sleep and regional
cerebral blood flow assessed by PET (collaborative project with Clinic of Nuclear
Medicine); sleep and EEG analysis in parkinsonian and pain patients before and after
thalamotomy (collabora tive project with the Clinic of Neurosurgery), and in stroke
patients (coll. with Clinic of Neurology, Univ. Bern).
Vice-president ("Prorektor für Forschung") of the University of Zurich since
Previous and Current Research
- Investigation of the physiological and neurochemical processes underlying the
regulation of sleep in humans and animals
- Effect of CNS-active substances on sleep, daytime vigilance and body or brain
temperature (e.g. benzodiazepine hypnotics and analogs; alcohol, caffeine, melatonin and
synthetic congeners; adenosine receptor agonists and antagonists; serotonin-2 antagonists)
- Comparative sleep physiology
- Natural hypometabolic states (daily torpor) and sleep
- Sleep and circadian rhythms in normal and genetically manipulated mice
- Signal analysis of the sleep EEG and mathematical modeling of sleep processes
- Sleep and sleep EEG in neurological and neurosurgical patients (collaborative
- Changes of regional cerebral blood flow as assessed by PET after sleep
deprivation and hypnotics (collaborative project)
- Sleep and immunology (collaborative projects)
Figure: Screen-shot of human sleep recording The "History view"
on the left is a summary of the entire time since the recording was started.
In the example shown, the recording had been going on for roughly 1.5 hours. A
first slow-wave sleep episode has already occurred (white peaks). The larger
"signal view" to the right of the screen shows the last 20 seconds
of the signals plus some additional values at the bottom.
Topographic analysis of the sleep EEG; search for use-dependent local features
of sleep; sleep in mice devoid of prion protein; clinical sleep studies
- Aeschbach D, Cajochen C, Landolt H, Borbély A A: (1996) Homeostatic sleep
regulation in habitual short sleepers and long sleepers. Am. J. Physiol., 270:R41-R53.
- Tobler I, Gaus S E, Deboer T, Achermann P, Fischer M, Rülicke T, Moser M, Oesch
B, McBride P A, Manson J C: (1996) Altered circadian activity rhythms and sleep in mice
devoid of prion protein. Nature, 380: 639-642.
- Achermann P, Borbély A A: (1998) Coherence analysis of the human sleep
electroencephalogram. Neuroscience, 85: 1195-1208.
Last update: 14. 02. 2005, Webmaster
/ Institute of Pharmacology and Toxicology