PUBLICATIONS
RESEARCH PUBLICATIONS
2013
Straub C.J., Lau H., Parlato R., Schuetz G., Fritschy J.-M., and Rudolph U. Bidirectional regulation of intravenous general anesthetic actions by α3-containing GABAA receptors. J. Anesthesiol., Jan 8. [Epub ahead of print] (2013).
2012
Aguado C., Fernández-Alacid L., Cabañero M.J., Yanagawa Y., Schilling K., Watanabe M., Fritschy J.-M., and Luján R. Differential maturation of GIRK2-expressing neurons in the mouse cerebellum. J. Chem. Neuroanat, Dec 20. [Epub ahead of print] (2012).
Koester C., Rudolph U., Häenggi T., Papilloud A., Fritschy J.-M., and Crestani F. Dissecting the role of γ-aminobutyric acid type A receptors in defensive behavioral control of anxiety. Pharmacol. Biochem. Behav. 103, 541-549 (2012).
Marowsky A., Rudolph U., Fritschy J.-M., and Arand M. Tonic inhibition in the basolateral amygdala is mediated by a3 subunit-containing GABAA receptors. J. Neurosci. 32, 611-619 (2012).
Pallotto M., Nissant A., Fritschy J.-M., Rudolph U., Sassoè-Pognetto M., Panzanelli P., and Lledo P.M. Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. J. Neurosci. 32, 9103-9115 (2012).
Pfister S., Dietrich M.G., Sidler C., Fritschy J.-M, Knuesel I., Elsaesser R. Characterization and turnover of CD73/IP3R3-positive microvillar cells in the adult mouse olfactory epithelium. Chem. Senses, 37, 859-868 (2012).
Paul J., Zeilhofer H.U., and Fritschy J.-M. Selective distribution of GABAA receptor subtypes in mouse spinal dorsal horn neurons and primary afferents. J. Comp. Neurol. 520, 3895-3911 (2012).
2011
Panzanelli P., Gunn B.G., Schlatter M., Benke D., Tyagarajan S.K., Scheiffele P., Belelli D., Lambert J.J., Rudolph U., and Fritschy J.-M. Dystrophin anchors a1-GABAA receptors in perisomatic GABAergic synapses of hippocampal pyramidal cells. J. Physiol. 589, 4959-4980 (2011).
Duveau V., Madhusudan A., Caleo M., Knuesel I., and Fritschy J.-M. Impaired reelin processing and secretion by Cajal-Retzius cells contributes to the development of granule cell dispersion in a mouse model of temporal lobe epilepsy. Hippocampus 21, 935–944 (2011).
Deprez F., Zattoni M., Mura M. L., Frei K., and Fritschy J.-M. Adoptive transfer of T lymphocytes in immunodeficient mice influences epileptogenesis and neurodegeneration in a model of temporal lobe epilepsy. Neurobiol. Disease 44, 174-184 (2011).
Tyagarajan S.K., Ghosh H., Harvey K., and Fritschy J.-M. Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses. J. Cell Sci. 124, 2786-2796 (2011).
Duveau V., Laustela S., Gianolini F., Barth L., Vogt K.E., Keist R., Chandra D., Homanics G.E., Rudolph U., and Fritschy J.-M. Spatio-temporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. Eur. J. Neurosci. 34, 362-373 (2011).
Witschi R., Punnakkal P., Paul J., Walczak J.S., Cervero F., Fritschy J.-M., Kuner R., Keist R., Rudolph U., Zeilhofer H.U. Presynaptic a2-GABAA receptors in primary afferent depolarization and spinal pain control. J. Neurosci. 31, 8134-8142 (2011).
Lachos J., Zattoni M., Wieser H.G., Fritschy J.-M., Langmann T., Schmitz G., Errede M., Virgintino D., Yonekawa Y., and Frei K. Characterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. Epil. Res. Treatment, Art. ID 758407, 11 pages (2011); doi:10.1155/2011/758407.
Tyagarajan S.K., Ghosh H., Yévenes G.E., Nikonenko I., Ebeling C., Schwerdel C., Sidler C., Zeilhofer H.U., Gerrits B., Muller D., and Fritschy J.-M. Regulation of GABAergic synapse formation and plasticity by GSK3b-dependent phosphorylation of gephyrin. Proc. Natl. Acad. Sci. (USA) 108, 379-384 (2011).
Zattoni M., Mura M.L., Deprez F., Schwendener R.A., Engelhardt B., Frei K., and Fritschy J.-M. Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J. Neurosci 31, 4037-4050 (2011).
2010
Bürli T., Baer K., Ewers H., Sidler C., Fuhrer C., and Fritschy J.-M. Single particle tracking of a7 nicotinic acetylcholine receptors in hippocampal neurons reveals regulated confinement at glutamatergic and GABAergic perisynaptic sites. PloS One, 5, e11507 (2010).
Doehner J., Madhusudan A., Konietzko U., Fritschy J.-M., and Knuesel I. Co-localization of Reelin and proteolytic APP fragments in hippocampal plaques in aged wild type mice. J. Alzheimer Dis. 19, 1339-1357 (2010)
Tan K.R., Labouèbe G., Creton Y.C., Fritschy J.-M., Rudolph U., and Lüscher C. Neural basis for addictive properties of benzodiazepines. Nature 463, 769-774 (2010).
Prut L., Prenosil G., Willadt S., Vogt K., Fritschy J.-M., and Crestani F. A reduction in hippocampal GABAA receptor a5 subunits disrupts the memory for location of objects in mice. Genes, Brain, Behav., Feb 17. 1. Genes, Brain, Behav. 9, 478-488 ( 2010).
Duveau V. and Fritschy J.-M. PSA-NCAM-dependent GDNF signaling limits neurodegeneration and epileptogenesis in temporal lobe epilepsy. Eur. J. Neurosci., 32, 89-98 (2010).
Kocherhans S.*, Madhusudan A.*, Doehner J.*, Breu K.S., Nitsch R.M., Fritschy J.-M., and Knuesel I. Reduced Reelin expression accelerates amyloid-ß plaque formation and Tau pathology in transgenic AD mice. J. Neurosci., 30, 9027-9037, (2010).
2009
Panzanelli P., Bardy C., Nissant A., Pallotto M., Sassoè-Pognetto M., Lledo P.M., and Fritschy J.-M. Early synapse formation in developing interneurons of the adult olfactory bulb. J. Neurosci. 29, 15039-15052 (2009).
Lappe-Siefke C., Loebrich S., Hevers W., Waidmann O.B., Schweizer M., Fehr S., Fritschy J.-M., Dikic I., Eilers J, Wilson S. M., and Kneussel M. The Ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice. PLOS Genetics, 5, e1000631 (2009).
Loup F., Picard F., Yonekawa Y., Wieser H.G., and Fritschy J.-M. Selective changes in GABAA receptor subtypes in white matter neurons of patients with focal epilepsy. Brain, 132, 2449-2463 (2009).
Marowsky A., Burgener J., Falck J.R., Morisseau C., Hammock B.D., Fritschy J.-M., and Arand M. Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and their contribution to cerebral epoxyeicosanotrienoic acid metabolism. Neuroscience, 163, 646-661 (2009).
Balic E., Fritschy J.-M., Mohler H., Benke D. The a5H105R mutation impairs a5 selective binding properties by altered positioning of the a5 subunit in GABAA receptors containing two distinct types of a subunit. J. Neurochem., 110, 244-254 (2009).
Zheng F., Adelsberger H., Müller M.R., Fritschy J.-M., Werner S., and Alzheimer C. Activin tunes GABAergic transmission to modulate anxiety-like behavior. Biol. Psychiatry, 14, 332-346 (2009).
Hoon M., Bauer G., Fritschy J.-M., Moser T., Falkenburger B., and Varoqueaux F. Neuroligin 2 controls the maturation of GABAergic synapses and information processing in the retina. J. Neurosci., 29, 8039-8050 (2009).
2008
Kilic E., Spudich A.*, Kilic U., Rentsch K.M., Vig R., Matter C.M., Wunderli-Allenspach H., Fritschy J.-M., Bassetti C.L., and Hermann D.M. ABCC1: A gateway for pharmacological compounds to the ischemic brain. Brain 131, 2679-2689 (2008).
Winsky-Sommerer R., Knapman A., Fedele D.E., Schofield C.M., Vyazovskiy V.V., Rudolph U., Huguenard J.R., Fritschy J.-M., and Tobler I. Normal sleep homeostasis and lack of epilepsy phenotype in GABAA receptor a3 subunit-null mice. Neurosci. 154, 595-605 (2008).
Patrizi A., Scelfo B., Viltono L., Fukaya M., Watanabe M., Strata P., Varoqueaux F., Brose N., Fritschy J.-M., and Sassoè-Pognetto M. GABAA receptors stabilize inhibitory synapses and prevent heterologous synapse formation in developing Purkinje cells. Proc. Natl. Acad. Sci. 105, 13151-13156 (2008).
Peden D.R., Petitjean C.M., Herd M.B., Durakoglugil M., Rosahl T., Wafford K., Homanics G.E., Belelli D., Fritschy J.-M. , and Lambert J.J.Developmental plasticity of thalamocortical synaptic and extrasynaptic GABAA receptors. J. Physiol. 586, 985-987 (2008).
Knabl J., Witschi R., Hösl K., Reinold H., Zeilhofer U., Ahmadi S., Brockhaus J., Sergejeva M., Hess A., Brune K., Fritschy J.-M., Rudolph U., Mohler H., and Zeilhofer H.U. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature 451, 330-334 (2008).
Tretter V., Jacob T., Mukherjee J., Fritschy J.-M., Pangalos M.N., and Moss S.J. The clustering of GABAA receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor a2 subunits to gephyrin. J. Neurosci. 28, 1356-1365 (2008).
Bethmann K., Fritschy J.-M., Brandt C., and Löscher W. Antiepileptic drug resistant rats differ from drug responsive rats in GABAA-receptor subunit expression in a model of temporal lobe epilepsy. Neurobiol. Dis., 31, 169-187 (2008).
Sillitoe R.V., Chung S.-H., Fritschy J.-M., Hoy M., and Hawkes R. Golgi cell dendrites are restricted by Purkinje cell stripe boundaries in the adult mouse cerebellar cortex. J. Neurosci., 28, 2820-2826 (2008).
Viltono L., Patrizi A., Fritschy J.-M., and Sassoè-Pognetto M. Synaptogenesis in the cerebellar cortex: differential regulation of gephyrin and GABAA receptors at somatic and dendritic synapses of Purkinje cells. J. Comp. Neurol., 508, 579-591 (2008).
Zeller A., Crestani F., Camenisch I., Iwasato T., Itohara S., Fritschy J.-M., and Rudolph U. Cortical glutamatergic neurons mediate the motor sedative action of diazepam. Mol. Pharmacol., 73, 282-291 (2008).
2007
Buerli T., Pellegrino C., Baer K., Lardi-Studler B., Chudotvorova I., Fritschy J.-M., Medina I., and Fuhrer C.Efficient transfection of DNA or shRNA vectors into neurons using magnetofection. Nature Protocols 2, 3090-3101 (2007)
Eugène E., Depienne C., Baulac S., Baulac M., Fritschy J.-M., Le Guern E., Miles R., and Poncer J.C.GABRG2 mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition. J. Neurosci. 27, 14108-14116 (2007).
Simat M., Ambrosetti L., Lardi-Studler B., and Fritschy J.-M. GABAergic synaptogenesis marks the onset of differentiation of basket and stellate cells in mouse cerebellum. Eur. J. Neurosci. 26, 2239-2256 (2007).
Simat M, Parpan F, Fritschy J-M. Heterogeneity of glycinergic and GABAergic interneurons in the granule cell layer of mouse cerebellum. J Comp Neurol 500:71-83. (2007)
Simon C., Stieger B., Kullak-Ublick G.A., Fried M., Mueller S., Fritschy J.-M., Wieser H.G., and Pauli-Magnus C. Predictive value of intestinal expression levels of CYP3A4, CYP2C9/19, MDR1 (ABCB1) and MRP2 (ABCC2) for plasma levels and dose requirement of carbamazepine and phenytoin in patients with epilepsy. Acta Neurol. Scand. 115, 232-242 (2007)
Lardi-Studler B., Smolinsky B., Petitjean C.M., Koenig F., Sidler C., Meier J.C., Fritschy J.-M.*, and Schwarz G.* Vertebrate-specific sequences in the gephyrin E-domain regulate cytosolic aggregation and postsynaptic clustering. J. Cell Sci. 120, 1371-1382 (2007) * equal contribution.
Lagier S.†, Panzanelli P.†, Russo R.E., Nissant A., Bathellier B., Sassoè-Pognetto M., Fritschy J.-M.*, and Lledo P.M.* GABAergic inhibition at reciprocal synapses tunes ? oscillations in the olfactory bulb. Proc. Natl. Acad. Sci. USA 104, 7259-7264 (2007). †*equal contribution
Panzanelli P., Fritschy J.-M., Yanagawa Y., Obata K., and Sassoè-Pognetto M. GABAergic phenotype of periglomerular cells in the rodent olfactory bulb. J. Comp. Neurol. 502, 990-1002 (2007)
Baer K., Burli T., Huh K.-H., Wiesner A., Erb-Vögtli S., Göckeritz-Dujmovic D., Moransard M., Nishimune A., Rees M.I., Henley J.M., Fritschy J.-M., and Fuhrer C. PICK1 interacts with a7 neuronal nicotinic acetylcholine receptors and controls their clustering. Mol. Cell. Neurosci. 35, 339-355 (2007)
Schneider Gasser EM, Duveau V., Prenosil G., and Fritschy J.-M. Reorganization of GABAergic circuits maintains GABAA receptor-mediated transmission onto CA1 interneurons in a1 subunit-null mice. Eur. J. Neurosci. 25, 3287-3304 (2007).
Lorenzo L.E, Russier M., Barbe A., Fritschy J.-M., and Bras H. Differential organization of GABAA and glycine receptors on the somatic and dendritic compartments of rat oculomotor neurons. J. Comp. Neurol. 504, 112-126 (2007).
2006
Fritschy J-M, Panzanelli P, Kralic JE, Vogt KE, Sassoè-Pognetto M. Differential dependence of axo-dendritic and axo-somatic GABAergic synapses on GABAA receptors containing the a1 subunit in Purkinje cells. J Neurosci 26:3245-3255. (2006)
Kralic JE, Sidler, C, Parpan, F, Homanics, G, Morrow, AL and Fritschy, J-M. Compensatory alteration of inhibitory synaptic circuits in thalamus and cerebellum of GABAA receptor a1 subunit knockout mice. J Comp Neurol 495:408-421. (2006)
Ledergerber D, Fritschy J-M, Kralic JE. Impairment of neuronal progenitor cell differentiation in a mouse model of temporal lobe epilepsy. Exp Neurol 199:130-142. (2006)
Lorenzo LE, Barbe A, Portalier P, Fritschy J-M, Bras H. Differential expression of GABAA and glycine receptors in ALS-resistant versus ALS-vulnerable motoneurons: possible implications for selective vulnerability of motoneurons. Eur J Neurosci, 23:3161-3170. (2006)
Loup F, Picard F, ré VM, Kehrli P, Yonekawa Y, Wieser HG and Fritschy J-M. Altered expression of a3-containing GABAA receptors in the neocortex of patients with focal epilepsy. Brain 129:3277-3289. (2006)
Prenosil GA, Schneider Gasser EM, Rudolph U, Keist R, Fritschy J-M, Vogt KE. Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in CA1 pyramidal cells. J Neurophysiol 96:846-857. (2006)
Schneider Gasser EM, Straub C, Panzanelli P, Weinmann O, Sassoè-Pognetto M, Fritschy J-M. Immunofluorescence in brain sections: simultaneous detection of pre- and postsynaptic proteins in identified neurons. Nature Protocols 1:1887-1897. (2006)
Simon C, Stieger B, Kullak-Ublick GA, Fried M, Mueller S, Fritschy J-M, Wieser HG, Pauli-Magnus C. Predictive value of intestinal expression levels of CYP3A4, CYP2C9/19, MDR1 (ABCB1) and MRP2 (ABCC2) for plasma levels and dose requirement of carbamazepine and phenytoin in patients with epilepsy. Acta Neurol Scand, online 20 Dec 2006. (2006)
Soontornmalai A, Vlaming MLH, Fritschy J-M. Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine blood brain barrier and choroid plexus. Neuroscience 138:159-169. (2006)
Studer FE, Fedele DE, Marowsky A, Schwerdel C, Wernli K, Vogt KE, Fritschy J-M, Boison D. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience 142:125-137. (2006)
Studer R, von Boehmer L, Haenggi T, Schweizer C, Benke D, Rudolph U, Fritschy J-M. Alteration of GABAergic synapses and gephyrin clusters in the thalamic reticular nucleus of GABAA receptor a3 subunit-null mice. Eur J Neurosci 24:1307-1315. (2006)
Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy J-M, Vacher CL, Müller M, Sansig G, Guetg N, Cryan JF, Kaupmann K, Gassmann M, Oertner TG, Bettler B. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50:589-601. (2006)
Volk HA, Arabadzisz D, Fritschy J-M, Brandt C, Bethmann K, Löscher W. Anti-epileptic drug-resistant rats differ from drug-responsive rats in hippocampal neurodegeneration and GABAA receptor ligand binding in a model of temporal lobe epilepsy. Neurobiol Disease 21:633-646. (2006)
Yu ZY, Wang W, Fritschy J-M, Witte OW, Redecker C. Changes in neocortical and hippocampal GABAA receptor subunit distribution during brain maturation and aging. Brain Res 1099:73-81. (2006)
2005
Arabadzisz D, Antal K, Parpan F, Emri Z, Fritschy J-M. Epileptogenesis and chronic seizures in a mouse model of temporal lobe epilepsy are associated with distinct EEG patterns and selective neurochemical alterations in the contralateral hippocampus. Exp Neurol 194:76-90. (2005)
Haenggi T, Schaub MC, Fritschy J-M. Molecular heterogeneity of the dystrophin-associated protein complex (DPC) in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin. Cell Tissue Res 319:299-313. (2005)
Koksma JJ, Fritschy J-M, Mack V, Van Kesteren RE, Brussaard AB. Differential GABAA receptor clustering determines GABA synapse plasticity in rat oxytocin neurons around parturition. Mol Cell Neurosci 28:128-140. (2005)
Kralic JE, Lederberger D, Fritschy J-M. Disruption of the neurogenic potential of the dentate gyrus in a mouse model of temporal lobe epilepsy with focal seizures. Eur J Neurosci 22:1916-1927. (2005)
Panzanelli P, Perazzini AZ, Fritschy J-M, Sassoè-Pognetto M. Heterogeneity of GABAA receptor subtypes in mitral and tufted cells of the rat main olfactory bulb. J Comp Neurol 484:121-131. (2005)
Sauter K, Grampp T, Fritschy J-M, Kaupmann K, Bettler B, Mohler H, Benke D. Subtype-selective interaction with the transcription factor CHOP regulates cell surface expression of GABAB receptors. J Biol Chem 280:33566-33572. (2005)
Studler B, Sidler C, Fritschy J-M. Differential regulation of GABAA receptor and gephyrin postsynatic clustering in immature hippocampal neuronal cultures. J Comp Neurol 484:344-355. (2005)
van Rijnsoever C, Sidler C, Fritschy J-M. Internalized GABAA receptor subunits are transferred to an intracellular pool associated with the postsynaptic density. Eur J Neurosci 21:327-338. (2005)
Yee BK, Keist R, von Boehmer L, Studer R, Benke D, Hagenbuch N, Dong Y, Malenka RC, Fritschy J-M, Bluethmann H, Feldon J, Mohler H, Rudolph U. A schizophrenia-related sensorimotor deficit links a3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci USA 102:17154-17159. (2005)
Zeilhofer HU, Studler B, Arabadzisz D, Schweizer C, Ahmadi S, Layh B, Bösl MR, Fritschy J-M. Glycinergic neurons expressing EGFP in BAC transgenic mice. J Comp Neurol 482:123-141. (2005)
REVIEWS
Fritschy J.-M., Panzanelli P., and Tyagarajan S.K. Molecular and functional heterogeneity of GABAergic synapses. Cell. Mol. Life Sci., 69, 2485-2499 (2012).
Tyagarajan S.K. and Jean-Marc Fritschy GABAA receptors, gephyrin & homeostatic synaptic plasticity. J. Physiol., 588, 101-106 (2009)
Sassoè-Pognetto M., Panzanelli P., Lagier S., Fritschy J.-M., and Lledo P.-M. GABAA Receptor heterogeneity modulates dendrodendritic inhibition. Annals N.Y. Acad. Sci., 1170, 259-263 (2009)
Sarter, M., & Fritschy, J.M. Reporting statistical methods and statistical results in EJN. Eur. J. Neurosci. 28, 2363-2364 (2008)
Fritschy J.-M. Is my antibody staining specific? How to avoid pitfalls in immunohistochemistry. Eur. J. Neurosci. 28, 2365-2369 (2008)
Fritschy J.-M., Harvey R.J. and Schwarz G. Gephyrin, where do we stand, where do we go? Trends Neurosci. 31, 257-264 (2008)
Fritschy J.-M. Epilepsy, E/I balance and GABAA receptor plasticity. Frontiers Mol. Neurosci 1:5, (2008)
Lardi-Studler B. and Fritschy J.-M. Matching of pre- and postsynaptic specializations during synaptogenesis. The Neuroscientist 13, 115-126 (2007)
Fritschy J-M, Panzanelli P. Molecular and synaptic organization of GABAA receptors in the cerebellum: effects of targeted subunit gene deletions. Cerebellum 5:245-255. (2006)
Haenggi T, Fritschy J-M. Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue. Cell Mol Life Sci 63:1614-1631. (2006)
Ledergerber D, Fritschy J-M. Significance of neurogenesis in temporal lobe epilepsy (TLE). Epileptology 23:178-186. (2006)
Mohler H, Fritschy J-M, Vogt K, Crestani F, and Rudolph U. Pathophysiology and pharmacology of GABAA receptors. Handbook Exp. Pharmacol. 16:225-247. (2005)