Institute of Pharmacology and Toxicology – Morphological and Behavioral Neuroscience

Research Areas  




Mircsof D., Langouët M., Rio M., Moutton S., Siquier-Pernet K., Bole-Feysot C., Cagnard N., Nitschke P., Gaspar L., Žnidarič M., Fritz A.K., Wolfer D.P., Schröter A., Bosshard G., Rudin M., Koester C., Crestani F., Seebeck P., Boddaert N., Fritschy J.-M., Munnich A., Amiel  J., Brown S.A., Tyagarajan S.K., and Colleaux L. NONO mutations cause syndromic intellectual disability and inhibitory synaptic defects. Nature Neurosci., in press (2015).

Angliker N., Burri M., Zaichuk M., Fritschy J.-M., and Rüegg M.A. mTORC1 and mTORC2 have largely distinct functions in Purkinje cells. Eur. J. Neurosci., in press (2015).

Hofer S.C., Ralvenius W.T., Gachet M.S. Fritschy J.-M., Zeilhofer H.U., and Gertsch J. Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla. Neuropharmacology pii: S0028-3908 (15) 00113-6, epub ahead of print (2015).

He Q., Duguid I., Clark B, Panzanelli P., Patel B., Thomas P., Fritschy J.-M., and Smart T.G. Interneuron- and GABAA receptor-specific inhibitory synaptic plasticity. Nature Comm. 16, 6:7364 (2015).

Deprez F., Pallotto M., Vogt F., Grabiec M., Virtanen M.A, Tyagarajan S.K., Panzanelli P., and Fritschy J.-M. Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb. J. Comp. Neurol. 523, 1998-2016 (2015).

Flores C.E., Nikonenko I., Mendez P., Fritschy J.-M., Tyagarajan S.K.*, and Muller D. Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation. Proc. Natl. Acad. Sci. USA 112, E65-72 (2015).

Pfister S., Weber T., Härtig W., Schwerdel C., Elsaesser R., Knuesel I., and Fritschy J.-M. A novel role of CFTR in maintaining adult mouse olfactory neuronal homeostasis. J. Comp. Neurol. 526, 406-430 (2015).


Antonelli R., Pizzarelli R., Pedroni A., Fritschy J.-M., Del Sal G, Cherubini E., and Zacchi P.
Pin1-dependent signaling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interaction. Nature Comm. 5, 5066 (2014).

Accardi M.V., Daniels B.A., Brown P.M.W.G., Fritschy J.M., Tyagarajan S.K. and Bowie D. Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nature Comm. 5, 3168 (2014).

Notter T.*, Panzanelli P.*, Pfister S., Mircsof D., and Fritschy J.-M. A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse CNS. Eur. J. Neurosci. 39, 165-175 (2014). *Equal contribution

Paul J., Yévenes G., Benke D., Di Lio A., Ralvenius W., Witschi R., Scheurer L., Cook J., Rudolph U., Fritschy J.-M., and Zeilhofer H.U. Antihyperalgesia by α2-GABAA receptors occurs via a genuine spinal action and does not involve supraspinal sites. Neuropharmacology 39, 477-487 (2014).


Calcinaghi N., Wyss M.T., Jolivet R., Singh A., Keller A.L., Winnik S., Fritschy J.-M., Buck A., Matter C.M., and Weber B. Multimodal imaging reveals impaired neurovascular coupling in sustained hypertension. Stroke, 44,1957-1964 (2013)

Tyagarajan S.K., Ghosh H., E. Yévenes G.E., Imanishi SY, Zeilhofer H.U., Gerrits B., and Fritschy J.-M. ERK and GSK3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism. J. Biol. Chem. 288, 9634-9647 (2013)

Straub C.J., Lau H.,  Parlato R., Schuetz G., Fritschy J.-M., and Rudolph U. Bidirectional regulation of intravenous general anesthetic actions by α3-containing GABAA receptors. J. Anesthesiol., 118, 562-576 (2013)

Aguado C., Fernández-Alacid L., Cabańero M.J., Yanagawa Y., Schilling K., Watanabe M., Fritschy J.-M., and Luján R. Differential maturation of GIRK2-expressing neurons in the mouse cerebellum. J. Chem. Neuroanat, 47, 79-89 (2013)

Koester C., Rudolph U., Haenggi T., Papilloud A., Fritschy J.-M., and Crestani F. Dissecting the role of γ-aminobutyric acid type A receptors in defensive behavioral reactivity to mild threat. Pharmacol. Biochem. Behav. 103, 541-549 (2013).


Marowsky A., Rudolph U., Fritschy J.-M., and Arand M. Tonic inhibition in the basolateral amygdala is mediated by a3 subunit-containing GABAA receptors. J. Neurosci. 32, 611-619 (2012).

Pallotto M., Nissant A., Fritschy J.-M., Rudolph U., Sassoč-Pognetto M., Panzanelli P., and Lledo P.M. Early formation of GABAergic synapses governs the development of adult-born neurons in the olfactory bulb. J. Neurosci. 32, 9103-9115 (2012).

Pfister S., Dietrich M.G., Sidler C., Fritschy J.-M, Knuesel I., Elsaesser R. Characterization and turnover of CD73/IP3R3-positive microvillar cells in the adult mouse olfactory epithelium. Chem. Senses, 37, 859-868 (2012).

Paul J., Zeilhofer H.U., and Fritschy J.-M. Selective distribution of GABAA receptor subtypes in mouse spinal dorsal horn neurons and primary afferents. J. Comp. Neurol. 520, 3895-3911 (2012).


Panzanelli P., Gunn B.G., Schlatter M., Benke D., Tyagarajan S.K., Scheiffele P., Belelli D., Lambert J.J., Rudolph U., and Fritschy J.-M. Dystrophin anchors a1-GABAA receptors in perisomatic GABAergic synapses of hippocampal pyramidal cells. J. Physiol. 589, 4959-4980 (2011).

Duveau V., Madhusudan A., Caleo M., Knuesel I., and Fritschy J.-M. Impaired reelin processing and secretion by Cajal-Retzius cells contributes to the development of granule cell dispersion in a mouse model of temporal lobe epilepsy. Hippocampus 21, 935–944 (2011).

Deprez F., Zattoni M., Mura M. L., Frei K., and Fritschy J.-M. Adoptive transfer of T lymphocytes in immunodeficient mice influences epileptogenesis and neurodegeneration in a model of temporal lobe epilepsy. Neurobiol. Disease 44, 174-184 (2011).

Tyagarajan S.K., Ghosh H., Harvey K., and Fritschy J.-M. Collybistin splice variants differentially interact with gephyrin and Cdc42 to regulate gephyrin clustering at GABAergic synapses. J. Cell Sci. 124, 2786-2796 (2011).

Duveau V., Laustela S., Gianolini F., Barth L., Vogt K.E., Keist R., Chandra D., Homanics G.E., Rudolph U., and Fritschy J.-M. Spatio-temporal specificity of GABAA receptor-mediated regulation of adult hippocampal neurogenesis. Eur. J. Neurosci. 34, 362-373 (2011).

Witschi R., Punnakkal P., Paul J., Walczak J.S., Cervero F., Fritschy J.-M., Kuner R., Keist R., Rudolph U., Zeilhofer H.U. Presynaptic a2-GABAA receptors in primary afferent depolarization and spinal pain control. J. Neurosci. 31, 8134-8142 (2011).

Lachos J., Zattoni M., Wieser H.G., Fritschy J.-M., Langmann T., Schmitz G., Errede M., Virgintino D., Yonekawa Y., and Frei K. Characterization of the gene expression profile of human hippocampus in mesial temporal lobe epilepsy with hippocampal sclerosis. Epil. Res. Treatment, Art. ID 758407, 11 pages (2011); doi:10.1155/2011/758407.

Tyagarajan S.K., Ghosh H., Yévenes G.E., Nikonenko I., Ebeling C., Schwerdel C., Sidler C., Zeilhofer H.U., Gerrits B., Muller D., and Fritschy J.-M. Regulation of GABAergic synapse formation and plasticity by GSK3b-dependent phosphorylation of gephyrin. Proc. Natl. Acad. Sci. (USA) 108, 379-384 (2011).

Zattoni M., Mura M.L., Deprez F., Schwendener R.A., Engelhardt B., Frei K., and Fritschy J.-M. Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. J. Neurosci 31, 4037-4050  (2011).


Fritschy JM. Significance of GABAA receptor heterogeneity: clues from developing neurons. Adv Pharmacol. 73:13-39 (2015)

Fritschy J.-M. and Panzanelli P. GABAA receptors and plasticity of inhibitory neurotransmission in the CNS. Eur. J. Neurosci. 39, 1845-1865 (2014).

Tyagarajan S.K. and Fritschy J.-M. Gephyrin, a master regulator of neuronal function? Nature Neurosci. Rev., 15, 141-156 (2014).

Fritschy J.-M., Panzanelli P., and Tyagarajan S.K. Molecular and functional heterogeneity of GABAergic synapses. Cell. Mol. Life Sci., 69, 2485-2499 (2012).


Fritschy J.-M. & Panzanelli P. Extrasynaptic GABAA receptors: subunit composition, distribution, and regulation. In “Extrasynaptic GABAA receptors” (Errington A., Crunelli V., eds.) Springer, in press (2014).

Möhler H, Benke D, Rudolph U, Fritschy J.-M. GABAA receptors.  In: "Ion Channels, From Structure to Function" (Kew J. and Davies C., eds.) Oxford University Press, Oxford, pp 263 - 276 (2010).