Institute of Pharmacology and Toxicology – Morphological and Behavioral Neuroscience

Research Areas  



Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, Games D, Schenk D (2011) Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One 6(4): e19338

Prasad K, Tarasewicz E, Ohman Strickland PA, O’Neill M, Mitchell SN, Merchant K, Tep S, Hilton K, Datwani A, Buttini M, Mueller-Steiner S, Richfield EK (2011) Biochemical and morphological consequences of human α-synuclein expression in a mouse α-synuclein null background. European J Neurosci 33(4): 642-656

Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L (2008) Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer’s disease. Neuron 60(2): 247-257

Kunz TH, Mueller-Steiner S, Schwerdtfeger K, Kleiner P, Troxler H, Kelm JM, Ittner LM, Fischer JA, Born W (2007) Interaction of receptor-activity-modifying protein 1 with tubulin. Biochim Biophys Acta 1770(8): 1145-1150

Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Wang X, Yu G, Esposito L, Mucke L, Gan L (2006) Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer’s disease. Neuron 51(6): 703-714

Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L (2005) SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-kB signaling. J Biol Chem 280(48): 40364-40374

Steiner S, Born W, Fischer JA, Muff R (2003) The function of conserved cysteine residues in the extracellular domain of human receptor-activity-modifying protein 1. FEBS Lett 555(2): 285-290

Steiner S, Muff R, Gujer R, Fischer JA, Born W (2002) The transmembrane domain of receptor-activity-modifying protein 1 is essential for the functional expression of a calcitonin gene-related peptide receptor. Biochemistry 41(38): 11398-11404


Method of increasing cathepsin B-induced cleavage of amyloid beta peptides (Gan L, Roberson E, Mucke L, Mueller-Steiner S) US Patent 8388953 issued March 5, 2013

Methods and compositions for reducing amyloid beta levels (Gan L, Roberson E, Mucke L, Mueller-Steiner S) US Patent 7951367 issued May 31, 2011