Institute of Pharmacology and Toxicology – Morphological and Behavioral Neuroscience

Research Areas  
Research

PUBLICATIONS

PEER-REVIEWED PUBLICATIONS

2012
Madhusudan Amrita, Vogel Prisca, Knuesel Irene (2012). Impact of prenatal immune system disturbances on brain development. J Neuroimmune Pharm, in press.
Krstic Dimitrije and Knuesel Irene (2012). Deciphering the mechanism underlying late-onset Alzheimer’s Disease. Nat Rev Neurology, 9:25-34.
Krstic Dimitrije, Rodriguez Myriam and Knuesel Irene (2012). Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLOS One, 7:1-11
Pfister S, Dietrich MG, Sidler C, Fritschy JM, Knuesel I, Elsaesser R (2012). Characterization and Turnover of CD73/IP 3 R3-positive Microvillar Cells in the Adult Mouse Olfactory Epithelium. Chem Senses 37
Krstic Dimitrije, Madhusudan Amrita, Doehner Jana, Vogel Prisca, Notter Tina, Imhof Claudine, Manalastas Abigail, Hilfiker Martina, Pfister Sandra, Schwerdel Cornelia, Riether Carsten, Meyer Urs and Knuesel Irene (2012). Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice. J Neuroinflammation, 9:151.
Muhia Mary, Willadt Silvia, Yee Benjamin K., Feldon Joram, Paterna Jean-Charles, Schwendener Severin, Vogt Kaspar, Kennedy Mary B. and Knuesel Irene (2012). Molecular and behavioral changes associated with adult hippocampus-specific SynGAP1 knockout. Learning and Memory, 19:268-281.
Doehner Jana, Genoud Christel, Imhof Claudine, Krstic Dimitrije, and Knuesel Irene (2012). Extrusion of misfolded and aggregated proteins: A protective strategy of aging neurons? Eur J Neurosci, 35:1938-1950.
Klohs Jan, Baltes Christof, Kranz-Princz Felicitas, Ratering David, Nitsch Roger, Knuesel Irene, and Rudin Markus (2012). Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAbeta mice. J Neurosci, 32:1705-1713.
2011
Slomianka Lutz, Amrein Irmgard, Knuesel Irene, Sørensen Jens C, and Wolfer David P (2011). Hippocampal pyramidal cells: the reemergence of cortical lamination. Brain Struc Funct, 216:301-317.
Knuesel Irene (2011). Prenatal infection as driving force of aging-associated neurodegenerative diseases. PRAXIS, 1005:299-304.
Klohs Jan, Deistung Andreas, Schweser Ferdinand, Grandjean Joanes, Dominietto Marco, Waschkies Conny, Fischer Rudolf, Nitsch Roger M., Knuesel Irene, Reichenbach Jürgen, and Rudin Markus (2011). Improved detection of cerebral microbleeds with quantitative susceptibility mapping in the ArcAbeta mouse model of cerebral amyloidosis. J Cerebr Blood F Met, 3112:2282-2292.
Duveau Venceslas, Madhusudan Amrita, Caleo Matteo, Knuesel Irene and Fritschy Jean-Marc (2011). Impaired Reelin processing and secretion by Cajal-Retzius cells contributes to the development of granule cell dispersion in a mouse model of temporal lobe epilepsy. Hippocampus, 21: 935-944
2010
Knuesel Irene (2010). Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases. Prog. Neurobiol, 91:257-274.
Doehner Jana and Knuesel Irene (2010). Reelin-mediated signaling during normal and pathological forms of aging. Aging and Disease, 1:12-29.
Kocherhans Samira, Madhusudan Amrita, Doehner Jana, Breu Karin S., Nitsch Roger M., Fritschy Jean-Marc, and Knuesel Irene (2010). Reduced Reelin expression accelerates amyloid-beta plaque formation and Tau pathology in transgenic AD mice. J Neurosci, 30:9228-9240.
Arabadzisz Dimitrula, Heijtz-Diaz Rochellys, Knuesel Irene, Weber Elisabeth, Pilloud Sonia, Dettling Andrea C., Feldon Joram, Law Amanda J., Harrison Paul, and Pryce Christopher R. (2010) Primate early life stress leads to long-term mild hippocampal decreases in corticosteroid receptor expression. Biol Psychiatry, 67:1106-1109.
Doehner Jana, Madhusudan Amrita, Konietzko Uwe, Fritschy Jean-Marc, and Knuesel Irene (2010). Co-localization of Reelin with proteolytic APP fragments in hippocampal plaques in aged wild-type mice. J Alzheimers Dis, 19:1339-57.
Muhia Mary, Yee Benjamin K., Feldon Joram, Markopoulos Foivos, and Knuesel Irene (2010). Disruption of hippocampus-regulated behavioural and cognitive processes by heterozygous constitutive deletion of SynGAP. Eur J Neurosci, 31:529-43.
Meyer Urs, Knuesel Irene, Nyffeler Myriel, Feldon Joram (2010). Chronic clozapine treatment improves prenatal infection-induces working memory deficits without influencing adult hippocampal neurogenesis. Psychopharmacology, 208:531-43.
2009
Muhia Mary, Feldon Joram, Knuesel Irene, and Yee K. Benjamin (2009). Appetitively motivated instrumental learning in SynGAP heterozygous knockout mice. Behav. Neurosci, 23:1114-28.
Madhusudan Amrita, Sidler Corinne, and Knuesel Irene (2009). Accumulation of Reelin-positive plaques is accompanied by a decline in basal forebrain projection neurons during normal aging. Eur J Neurosci, 30:1064-76.
Knuesel Irene, Nyffeler Myriel, Mormede Cecile, Muhia Mary, Meyer Urs, Pietropaolo Susanna B., Yee Benjamin K., Pryce Chrisopher R., LaFerla Frank M., Marighetto Aline and Feldon Joram (2009). Age-related accumulation of Reelin in amyloid-like plaques. Neurobiol Aging, 30:697-716
2008
Meyer Urs, Nyffeler Myriel, Yee Benjamin K., Knuesel Irene, and Feldon Joram (2008). Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice. Brain Behav Immun, 22:469-86 
Meyer Urs, Nyffeler Myriel, Schwendener Severin, Knuesel Irene, Yee Benjamin K, Feldon Joram (2008). Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge. Neuropsychopharmacology, 33: 441-56  
2007
Leventopoulos M, Ruedi-Bettschen D, Knuesel I, Feldon J, Pryce CR, Opacka-Juffry J (2007). Long-term effects of early life deprivation on brain glia in Fischer rats. Brain Res 1142:119-26. 
Nyffeler Myriel, Zhang Wei-Ning, Feldon Joram, and Knuesel Irene (2007). Differential expression of postsynaptic density proteins in age-related spatial learning impairments. Neurobiol Aging 28:143-55 
2006
Nyffeler Myriel, Meyer Urs, Yee Benjamin K., Feldon Joram and Knuesel Irene (2006). Maternal immune activation during pregnancy affects limbic GABAA receptor immunoreactivity of the adult offspring: Implications for schizophrenia. Neuroscience 143:51-62 
Meyer Urs, Nyffeler Myriel, Engler Andrea, Urwyler, Schedlowski Manfred, Knuesel Irene, Yee Benjamin K., and Feldon Joram (2006). The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci 26:4752-62. 
Yee Benjamin K., Balic Ela, Singer Philipp, Schwerdel Cornelia, Grampp Thomas, Gabernet Laetitia, Knuesel Irene, Benke Dietmar, Feldon Joram, Mohler Hanns, and Boison Detlev (2006). Disruption of glycine transporter 1 in forebrain neurons is associated with negative symptoms of schizophrenia. J. Neurosci, 26:3169-81. 
2005
Pryce Christopher R, Feldon Joram, Fuchs Eberhard, Knuesel Irene, Oertle Thomas, Sengstag Christian, Spengler Marianne, Weber Elisabeth, Weston Anna, and Jongen-Rélo Ana (2005). Postnatal ontogeny of hippocampal expression of the mineralocorticoid and glucocorticoid receptors in the common marmoset monkey. Eur J Neurosci, 21:1521-35. 
Knuesel Irene, Elliot Abigail, Chen Hong-Jung, and Kennedy Mary B (2005). The role of synGAP in regulating neuronal apoptosis. Eur J Neurosci, 21: 611-621 
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2004 - 1998
Vazquez Luis E., Chen Hong-Jung, Sakalova Irina, Knuesel Irene, and Kennedy Mary B. (2004). SynGAP regulates spine formation. J. Neurosci, 40:8862-72. 
Brunig Ina, Sutter Anthi, Knuesel Irene, Luscher Bernhard, and Fritschy Jean-Marc (2002). GABAergic terminals are required for postsynaptic clustering of Dystrophin but not of GABAA receptors and gephyrin. J Neurosci, 22: 4805-4813. 
Knuesel Irene, Riban Véronique, Zuellig Richard A, Schaub Marcus C., Grady R. Mark, Sanes Joshua R., and Fritschy Jean-Marc (2002). Increased vulnerability to kainate-induced seizures in utrophin-knockout mice. Eur J Neurosci, 15:1474-1484. 
Knuesel Irene, Zuellig Richard A., Schaub Marcus C., and Fritschy Jean-Marc (2001). Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy. Eur J Neurosci, 13:1113-1124. 
Briegel Hans, Knuesel Irene, and Timmermann Susanne E. (2001). Aedes aegypti: size, reserves, survival, and flight potential. J Vector Ecology 26:21-31. 
Knuesel Irene, Bornhauser Beat B., Zuellig Richard A., Heller Franziska, Schaub Marcus C., and Fritschy Jean-Marc (2000). Differential expression of utrophin and dystrophin in CNS neurons: An in situ hybridization and immunohistochemical study. J Comp Neurol 422:594-611.  
Zuellig Richard A., Bornhauser Beat C., Knuesel Irene, Heller Franziska, Fritschy Jean-Marc, and Schaub Marcus C. (2000). Identification and characterization of transcript and protein of a new short N-terminal utrophin isoform. J Cell Biochem 77:418-431. 
Knuesel Irene, Mastrocola Mario, Zuellig Richard A., Bornhauser Beat C., Schaub Marcus C., and Fritschy Jean-Marc (1999). Altered synaptic clustering of GABAA-receptors in mice lacking dystrophin (mdx mice). Eur J Neurosci 11: 4457-4463.  
Knuesel Irene, Murao Savao, Shin Takashi, Amachi Teruo, and Hartmut Kayser (1998). Comparative studies of Suidatrestin, a specific inhibitor of trehalases. Comp Biochem Physiol Part B 120: 639-646. 
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ARTICLES AND BOOK CHAPTERS 

Knuesel Irene (2010). View from the Bench-Side. In: Quo vadis universitas? Kritische Beiträge zur Idee und Zukunft der Universität. Nr. 13, February 2010.
Knuesel Irene and Kennedy Mary B. (2004). Ca-CaM protein kinase II. In: xPharm (2004). Executive Editors S.J. Enna and David B. Bylund, Publisher, Elsevier Inc., New York.  

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