The goal of our research is to understand the neurobiological processes dissociating normal from pathological forms of aging and which are responsible for triggering the molecular cascades leading to neurodegeneration, accelerated senescence and cognitive impairments.
We are particularly interested in identifying the molecular and cellular mechanisms that underlie abnormal protein aggregations and neuronal cell death, two common features of age-related neurodegenerative diseases, like Alzheimer’s disease (AD).
Our work focuses on the sporadic or late-onset form of the disease which represents the most common neurodegenerative disorder worldwide. We are using a combination of in-vitro and in-vivo strategies, including molecular, biochemical, immunological, immunohistochemical, ultrastructural, pharmacological, and behavioural paradigms in order to model the onset and progression of the disease in mice.
The long-term goal of our research is to advance the development of novel therapeutic strategies targeting the neurodegenerative disease pathways characteristic of late-onset AD.