Institute of Pharmacology and Toxicology – Chronobiology and Sleep Research

Research Areas  

PUBLICATIONS

PODCAST The sleeping brain as a complex system

The complexity of Sleep
Wennekers T., Achermann P., Olbrich E. The complexity of sleep. (2011) Philosophical Transactions of the Royal Society A: Mathematical, Physical, and Engineering Sciences. Vol 369, No. 1952, 2011.

PUBLICATIONS

2015  

Crivelli F.#, Omlin X.#, Rauter G., von Zitzewitz J., Achermann P. and Riener R. (2015) Somnomat: A novel actuated bed to investigate the effect of vestibular stimulation. Medical & Biological Engineering & Computing, in press.
# contributed equally to this work

 

Lustenberger C., O’Gorman R., Pugin F., Tüshaus L., Wehrle F., Achermann P. and Huber R. (2015) Sleep spindles are related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects. Schizophr. Bull., in press.

 

Lustenberger C., Murbach M., Tüshaus L., Wehrle F., Kuster N., Achermann P. and Huber R. (2015) Inter-individual and intra-individual variation of the effects of pulsed RF EMF exposure on the human sleep EEG. Bioelectromagnetics, in press.

 

Pugin F., Metz A.J., Wolf M., Achermann P., Jenni O.G. and Huber R. (2015) Local increase of sleep SWA after three weeks of working memory training in children and adolescents. Sleep, in press.

 

Stadelmann K., Latshang T.D., Lo Cascio C.M., Clark R., Huber R., Kohler M., Achermann P.* and Bloch K.E.* (2015) Impaired postural control in healthy men at moderate altitude (1630m and 2590m). Data from a randomized trial. PLoS One, in press.
* shared senior authorship

 

Tarokh L., Rusterholz T., Achermann P.* and Van Dongen H.P.A.* (2015) The spectrum of the non-rapid eye movement sleep EEG following total sleep deprivation is trait-like. J. Sleep Res., in press.
* shared senior authorship

 

Tesler N., Latshang T.D., Lo Cascio C.M., Stadelmann K., Stoewhas A.C., Kohler M., Bloch K.E., Achermann P. and Huber R. (2015) Ascent to moderate altitude impairs overnight memory improvements. Physiol. & Behav. 139, 121-126.

 
2014  

Achermann P., Tarokh L. (2014) Human sleep and its regulation. Kosmos 303, 173-180.

 

Ayers L., Stöwhas A.C., Ferry B., Latshang T.D., Lo Cascio C.M., Sadler R., Stadelmann K., Tesler N., Huber R., Achermann P., Bloch K.E., Kohler M. (2014) Circulating levels of cell-derived microparticles are reduced by mild hypobaric hypoxia: data from a randomised controlled trial. Eur. J. Appl. Physiol. 114, 1067-1073.

 

Fattinger S., Jenni O.G., Schmitt B., Achermann P., and Huber R. (2014) Overnight changes in the slope of sleep slow waves during infancy. Sleep 37, 245-53.

 

Holst S., Bersagliere A., Bachmann V., Berger W., Achermann P., and Landolt H.-P. (2014) Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J. Neurosci. 34, 566-573.

 

Metz A. J., Pugin F., Huber R., Achermann P.*, and Wolf M.* (2014) Changes of crebral tissue oxygen saturation at sleep transitions in adolescents. Advances in Experimental Medicine and Biology 812, 279-285.
* shared senior authorship.

 

Murbach M., Neufeld E., Christopoulou M., Achermann P., and Kuster N. (2014) Modeling of EEG electrode artifacts and thermal ripples in human radiofrequency exposure studies. Bioelectromagnetics, 35, 273–283.

 

Olbrich E., Landolt H.-P., and Achermann P. (2014) Effect of prolonged wakefulness on EEG oscillatory activity during sleep. J. Sleep Res. 23, 253-260.

 

Stadelmann K., Latshang T.D., Tarokh L., Lo Cascio C.M., Tesler N., Stöwhas A.C., Kohler M., Bloch K.E., Huber R., and Achermann P. (2014) Sleep respiratory disturbances and arousals at moderate altitude have overlapping EEG spectral signatures. J. Sleep Res. 23, 463-468.

 

Stadelmann K., Latshang T.D., Nussbaumer-Ochsner Y., Tarokh L., Ulrich S., Kohler M., Bloch K.E., and Achermann P. (2014) Impact of acetazolamide and CPAP on cortical activity in obstructive sleep apnea patients. PLoS One 9(4): e93931.

 

Tarokh L. Carskadon M.A.*, and Achermann P.* (2014) Early adolescent cognitive gains are marked by increased sleep EEG coherence. PLoS One 9(9): e106847.
* shared senior authorship

 
2013  

Benz D.C.#, Tarokh L.#, Achermann P.*, and Loughran S.P.* (2013) Trait-like characteristics of the waking EEG in early adolescence. BMC Neurosci., 14:117.
# contributed equally to this work; * shared senior authorship

 

Bersagliere A., Achermann P., Lo Russo G., Proserpio P., and Nobili L. (2013) Spindle frequency activity might provide lateralizing information in drug-resistant nocturnal mesial frontal lobe epilepsy: a pilot study on the contribution of sleep recordings. Seizure: European Journal of Epilepsy 22, 719-725.

 

Bersagliere A., Raduazzo I.D., Nardi M., Schiff S., Gatta A., Merkel C., Amodio P., Achermann P., and Montagnese S. (2013) Ammonia-related changes in cerebral electrogenesis in healthy subjects and patients with cirrhosis. Clin. Neurophysiol., 124, 492-496.

 

Kurth S., Achermann P., Rusterholz T., and LeBourgeois M.K. (2013) Development of brain EEG connectivity across early childhood – does sleep play a role? Brain Sciences, 3, 1445-1460.

 

Latshang T.D., Lo Cascio C.M., Stöwhas A.C., Grimm M., Stadelmann K., Tesler N., Achermann P., Huber R., Kohler M., and Bloch K.E. (2013) Are nocturnal breathing, sleep and cognitive performance impaired at moderate altitude (1630-2590m)? Sleep, 36, 1969-1976.

 

LeBourgeois M.K., Carskadon M.A., Akacem L.D., Simpkin C.T., Wright K.P., Achermann P., and Jenni O.G. (2013) Circadian phase and its relationship to nighttime sleep in toddlers. J. Biol. Rhythms, 28, 322-331.

 

Loughran S.P., Benz D.C., Schmid M.R., Murbach M., Kuster N., and Achermann P. (2013) No increased sensitivity in brain activity of adolescents exposed to mobile phone-like emissions. Clin. Neurophysiol., 124, 1303-1308.

 

Lustenberger C., Murbach M., Dürr R., Schmid M.R., Kuster N., Achermann P., and Huber R. (2013) Stimulation of the brain with radiofrequency electromagnetic field pulses affects sleep-dependent performance improvement. Brain Stimul. 6, 805-811.

 

Meisel C., Olbrich E., Shriki O., and Achermann P. (2013) Fading signatures of critical brain dynamics during sustained wakefulness in humans. J. Neurosci., 33, 17363–17372.

 

Metz A. J., Pugin F., Huber R., Achermann P.*, and Wolf M.* (2013) Brain tissue oxygen saturation increases during the night in adolescents. Advances in Experimental Medicine and Biology, 789, 113-119.
* shared senior authorship

 

Stadelmann K., Latshang T.D., Lo Cascio C.M., Tesler N., Stöwhas A.C., Kohler M., Bloch K.E., Huber R., and Achermann P. (2013) Quantitative changes in the sleep EEG at moderate altitude (1630m and 2590m). PLoS ONE, 8(10): e76945.

 

Stöwhas A.C., Latshang T.D., Lo Cascio C.M., Lautwein S., Stadelmann K., Tesler N., Ayers L., Berneis K., Gerber P., Huber R., Achermann P., Bloch K.E., and Kohler M. (2013) Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. PLoS ONE, 8(8): e70081.

 
2012  

Bersagliere A.#, Raduazzo I.D.#, Nardi M., Schiff S., Gatta A., Amodio P., Achermann P.*, and Montagnese S.* (2012) Induced hyperammonaemia may compromise the ability to generate restful sleep in patients with cirrhosis. Hepathology, 55, 869-878.
# contributed equally to this work; * shared senior authorship

 

Geiger A., Huber R., Kurth S., Ringli M., Achermann P.* and Jenni O.G.* (2012) Sleep EEG topography and children's intellectual ability. Neuroreport, 23, 93-97.
* shared senior authorship

 

Lustenberger C., Maric A., Dürr R., Achermann P. and Huber R. (2012) Triangular relationship between sleep spindle activity, general cognitive ability and the efficiency of declarative learning. PLoS One, 7(11), e49561.

 

Murbach M., Christopoulou M., Crespo-Valero P., Achermann P. and Kuster N. (2012) Exposure system to study hypotheses of ELF & RF electromagnetic field interactions of mobile phones with the central nervous system. Bioelectromagnetic, 33, 527-533.

 

Schmid M.R.#, Loughran S.P.#, Regel S.J., Murbach M., Bratic Grunauer A., Rusterholz T., Bersagliere A., Kuster N., and Achermann P. (2012) Sleep EEG alterations: Effects of different pulse-modulated radio frequency electromagnetic fields. J. Sleep Res. 21, 50–58
# contributed equally to this work

 

Schmid M.R., Murbach M., Lustenberger C., Maire M., Kuster N., Achermann P.*, and Loughran S.P.* (2012) Sleep EEG alterations: Effects of pulsed magnetic fields vs. pulse-modulated radio frequency electromagnetic fields. J. Sleep Res., 21(6) , 620-629
* shared senior authorship

 

Tarokh L., Carskadon M.A., and Achermann P. (2012) Dissipation of sleep pressure is stable across adolscence. Neuroscience, 216, 167-177.

 
2011  

Crespo-Valero P., Christopoulou M., Zefferer M., Christ A., Achermann P., Nikita K.S., and Kuster N. (2011) Novel methodology to characterize electromagnetic exposure of the brain. Phys. Med. Biol. 56, 383-396.

 

Geiger A., Huber R., Kurth S., Ringli M., Jenni O.G.* and Achermann P.* (2011) The sleep EEG as a marker of intellectual ability in school age children. Sleep 34, 181-189.
* shared senior authorship

 

Olbrich E., Claussen J.-C. and Achermann P. (2011) The multiple time scales of sleep dynamics as a challenge for modelling the sleeping brain. Phil. Trans. Roy. Soc. A. 369, 3884-3901.

 

Rusterholz T. and Achermann P. (2011) Topographical aspects in the dynamics of sleep homeostasis in young men: Individual patterns. BMC Neuroscience 2011, 12:8.

 

Tarokh L., Carskadon M.A. and Achermann P. (2011) Trait-Like Characteristics of the Sleep EEG Across Adolescent Development. J. Neurrosci. 31, 6371-6378.

 

Wennekers T., Achermann P., Olbrich E. The complexity of sleep. (2011) Philosophical transactions. Series A, undefined Mathematical, physical, and engineering sciences. Vol 369, No. 1952, 2011.

 
2010  

Achermann P. and Bersagliere A. (2010) Sleep homeostasis and slow oscillations in the human sleep EEG. Proceedings of Biosignal (July 14-16, 2010), Berlin, Germany

Bersagliere A. and Achermann P. (2010) Slow oscillations in human nonREM sleep EEG: effects of increased sleep pressure. J Sleep Res. 19, 228-237.

 

Geiger A., Achermann P. and Jenni O.G. (2010) Association between sleep duration and intelligence scores in healthy children. Developmental Psychology 46, 949-954.

 

Geiger A., Achermann P. and Jenni O.G. (2010) Sleep, intelligence and cognition from a developmental perspective: differentiation between traits and state-dependent aspects. Progress in Brain Research: Sleep and Cognition 184, Kerkhof G., Van Dongen H.P.A. (Eds.), in press.

 

Rusterholz T., Dürr R. and Achermann P. (2010) Inter-individual differences in the dynamics of sleep homeostasis. Sleep 33, 491-498.

 

Tarokh L., Carskadon M.A. and Achermann P. (2010) Developmental changes in brain connectivity assessed using the sleep EEG. Neuroscience 171, 622-634.

 
2009  

Achermann P. (2009) EEG analysis applied to sleep. Epileptologie 26, 28-33.

 
2008  

Boutry C. M., Kuehn S., Achermann P., Romann A., Keshvari J. and Kuster N. (2008) Dosimetric evaluation and comparison of different RF exposure apparatuses used in human volunteer studies. Bioelectromagnetics 29, 11-19.

 

Hermann D. M., Wachter K., Mathis J., Achermann P. and Bassetti C. L. (2008) Evolution of neurological, neuropsychological and sleep-wake disturbances in paramedian thalamic stroke. Stroke 39, 62-68.

 

Khatami R., Landolt H. P., Achermann P., Adam M., Rétey J. V., Werth E., Schmid D. and Bassetti C. L. (2008) Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation. Sleep 31, 859-867.

 

Olbrich E. and Achermann P. (2008) Analysis of the temporal organization of sleep spindles in the human sleep EEG using a phenomenological modeling approach. J. Biol. Phys. 34, 341-349.

 

Siccoli M. M., Rolli-Baumeler N., Achermann P. and Bassetti C. L. (2008) Correlation between sleep and cognitive functions after hemispheric ischaemic stroke. Eur. J. Neurol. 15, 565-572.

 
2007  

Khatami R., Landolt H.-P., Achermann P., Rétey J.V, Werth E., Mathis J., Bassetti, C.L. (2007) Insufficient non-REM sleep intensity in narcolepsy-cataplexy. Sleep, 30, 980-989.

 

Regel S.J., Gottselig J.M., Schuderer J., Tinguely G., Rétey J.V., Kuster N., Landolt H.-P. and Achermann P. (2007) Pulsed radio frequency radiation affects cognitive performance and the waking electroencephalogram. Neuroreport 18, 803-807.

 

Regel S. J., Tinguely G., Schuderer J., Adam M., Kuster N., Landolt H. P. and Achermann P. (2007) Pulsed radio-frequency electromagnetic fields: dose-dependent effects on sleep, the sleep EEG and cognitive performance. J. Sleep Res. 16, 253-258.

 

Tobler I. and Achermann P. (2007) Sleep homeostasis. Scholarpedia 2(10): 2432.

 

Vyazovskiy V.V., Achermann P. and Tobler I. (2007) Sleep homeostasis in the rat in the light and dark period. Brain Res. Bull. 74, 37-44.

 
2006   

Buckelmüller J., Landolt H.-P., Stassen H. H. and Achermann P. (2006) Trait-like individual differences in the human sleep electroencephalogram. Neuroscience 138, 351-356.

 

Gottselig J.M., Adam M., Rétey J.V., Khatami R., Achermann P. and Landolt H.P. (2006) Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. J. Sleep Res. 14, 31-40.

 

Jenni O.G., Deboer T. and Achermann P. (2006) Development of the 24-h rest-activity pattern in human infants. Infant Behavior & Development 29, 143-152.

 

Landolt H.-P., Glatzel M., Blättler T., Achermann P., Roth C., Mathis J., Weis J., Tobler I., Aguzzi A., and Bassetti C.L. (2006) Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease. Neurology 66, 1418-1424.

 

Regel S.J., Negovetic S., Röösli M., Berdińas V., Schuderer J., Huss A., Lott U., Kuster N., and Achermann P. (2006) UMTS base station-like exposure, well being and cognitive performance. Environmental Health Perspectives 114, 1270-1275.

 

Retéy, J.V., Adam M., Gottselig J.M., Khatami R., Dürr R., Achermann P., and Landolt H.-P. (2006) Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic activity. J. Neurosci., 26, 10472-10479.

 

Tinguely G., Huber R., Borbély A.A. and Achermann P. (2006) Non-rapid eye movement sleep with low muscle tone as a marker of rapid eye movement sleep regulation. BMC Neuroscience (9 January 2006), 7:2.

 

Tinguely G., Finelli L.A., Landolt H.-P., Borbély A.A. and Achermann P. (2006) Functional EEG topography in sleep and waking: State-dependent and state-independent features. NeuroImage 32, 283-292.

 
2005  

Hofer-Tinguely G., Achermann P., Landolt H.P., Regel S. J., Rétey J.V., Dürr R., Borbély A.A. and Gottselig J.M. (2005) Sleep inertia: performance changes after sleep, rest and active waking. Cog. Brain Res. 22, 323-331.

 

Huber R., Treyer V., Schuderer J., Berthold T., Buck A., Kuster N., Landolt H.P. and Achermann P. (2005) Exposure to pulse-modulated radio frequency electromagnetic fields affects regional cerebral blood flow. Eur. J. Neurosci. 21, 1000-1006.

 

Jenni O.G., Achermann P. and Carskadon M.A. (2005) Homeostatic sleep regulation in adolescents. Sleep 28, 1446-1454.

 

Olbrich E. and Achermann P. (2005) Analysis of oscillatory patterns in the human sleep EEG using a novel detection algorithm. J. Sleep Res. 14, 337-346.

 

 

EDITORIALS

Olbrich E., Achermann P., and Wennekers T. (2011) The sleeping brain as a complex system. Phil. Trans. Roy. Soc. A., 369: 3697-3707.

 

 

REVIEWS

Regel S.J. and Achermann P. (2011) Cognitive Performance Measures in Bioelectromagnetic Research - Critical Evaluation and Recommendations. Environmental Health 10, 10.

 

Achermann P. (2004) The two-process model of sleep regulation revisited. Aviat. Space Environ. Med. 75, A37-A43.

 

Achermann P. and Borbély A.A. (2003) Mathematical models of sleep regulation. Frontiers in Bioscience 8:683-693.

 

 

BOOK CHAPTERS

Achermann P., Tarokh L. and Peigneux P. (2014) Research design and quantitative methods. In: European Sleep Medicine Textbook. Bassetti C., Dogas Z., Peigneux P. (Eds.) pp. 517-527. European Sleep Research Society (ESRS), Regensburg.

 

Tarokh L. and Achermann P. (2013) Sleep homeostasis. In: Encyclopedia of Sleep, Kushida C. (Ed.), Vol. 1, pp. 413-417. Waltham, MA: Academic Press.

 

Achermann P. and Borbély A.A. (2011) Sleep homeostasis and models of sleep regulation. In: Principles and Practice of Sleep Medicine, 5th Edition, Kryger M.H., Roth T. and Dement W.C. (Eds.), pp. 431-444. Elsevier Saunders, Missouri.

 

Achermann P. (2006) Sleep. The Wiley Encyclopedia of Biomedical Engineering.

 

Borbély A.A. and Achermann P. (2005) Sleep homeostasis and models of sleep regulation. In: Principles and Practice of Sleep Medicine, 4th Edition, Kryger M.H., Roth T. and Dement W.C. (Eds.), pp. 405-417. Elsevier Saunders, Philadelphia.

 

Borbély A. A., Dijk D. J., Achermann P. and Tobler I. (2001) Processes underlying the regulation of the sleep-wake cycle. In: Circadian Clocks Takahashi J.A., Turek F.W., and Moore R.Y. (Eds.), pp. 457-479. Kluwer Academic / Plenum Publishers.

 

Achermann P. (2000) Topography of the sleep EEG in humans: power and coherence analysis. In: The Regulation of Sleep, Vol. 8 Borbély A.A., Hayaishi O., Sejnowski T., and Altman J.S. (Eds.), pp. 75-86. HFSP - Human Frontier Science Program..

 

Borbély A. A. and Achermann P. (2000) Sleep homeostasis and models of sleep regulation. In: Principles and Practice of Sleep Medicine, 3rd Edition Kryger M.H., Roth T., and Dement W.C. (Eds.), pp. 377-390. W.B. Saunders Co.

 

 

ENTIRE PUBLICATION RECORD