Institute of Pharmacology and Toxicology – Chronobiology and Sleep Research

Research Areas  

PUBLICATIONS

PODCAST The sleeping brain as a complex system

The complexity of Sleep
Wennekers T., Achermann P., Olbrich E. The complexity of sleep. (2011) Philosophical Transactions of the Royal Society A: Mathematical, Physical, and Engineering Sciences. Vol 369, No. 1952, 2011.

PUBLICATIONS

2014  

*Achermann P., Tarokh L. and Peigneux P. (2014) Research design and quantitative methods. In: Bassetti C., Dogas Z., Peigneux P. (Eds.) European Sleep Medicine Textbook, in press.

Achermann P., Tarokh L. (2014) Human sleep and its regulation. Kosmos, in press.

Ayers L., Stöwhas A.C., Ferry B., Latshang T.D., Lo Cascio C.M., Sadler R., Stadelmann K., Tesler N., Huber R., Achermann P., Bloch K.E., Kohler M. (2014) Circulating levels of cell-derived microparticles are reduced by mild hypobaric hypoxia: data from a randomised controlled trial. Eur. J. Appl. Physiol., in press.

Fattinger S., Jenni O.G., Schmitt B., Achermann P., and Huber R. (2014) Overnight changes in the slope of sleep slow waves during infancy. Sleep, 37, 245-53.

Holst S., Bersagliere A., Bachmann V., Berger W., Achermann P., and Landolt H.-P. (2014) Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J. Neurosci., 34, 566-573.

Lustenberger C., O’Gorman R., Pugin F., Tüshaus L., Wehrle F., Achermann P., and Huber R. (2014) Sleep spindles are related to schizotypal personality traits and thalamic glutamine/glutamate in healthy subjects. Schizophrenia Bulletin, in press.

Metz A. J., Pugin F., Huber R., Achermann P.*, and Wolf M.* (2014) Changes of crebral tissue oxygen saturation at sleep transitions in adolescents. Advances in Experimental Medicine and Biology, 812, 279-285.                                                         *shared last authorship.

Murbach M., Neufeld E., Christopoulou M., Achermann P., and Kuster N. (2014) Modeling of EEG electrode artifacts and thermal ripples in human radiofrequency exposure studies. Bioelectromagnetics, 35, 273–283.

Olbrich E., Landolt H.-P., and Achermann P. (2014) Effect of prolonged wakefulness on EEG oscillatory activity during sleep. J. Sleep Res., in press.

Stadelmann K., Latshang T.D., Tarokh L., Lo Cascio C.M., Tesler N., Stöwhas A.C., Kohler M., Bloch K.E., Huber R., and Achermann P. (2014) Sleep respiratory disturbances and arousals at moderate altitude have overlapping EEG spectral signatures. J. Sleep Res., in press.

Stadelmann K., Latshang T.D., Nussbaumer-Ochsner Y., Tarokh L., Ulrich S., Kohler M., Bloch K.E., and Achermann P. (2014) Impact of acetazolamide and CPAP on cortical activity in obstructive sleep apnea patients. PLoS One, 9(4): e93931.

2013  
Benz D.C.*, Tarokh L.*, Achermann P., and Loughran S.P. (2013) Trait-like characteristics of the waking EEG in early adolescence. BMC Neurosci., 14:117. * shared first authorship; shared senior authorship

Bersagliere A., Achermann P., Lo Russo G., Proserpio P., and Nobili L. (2013) Spindle frequency activity might provide lateralizing information in drug-resistant nocturnal mesial frontal lobe epilepsy: a pilot study on the contribution of sleep recordings. Seizure: European Journal of Epilepsy, 22, 719-725.

Bersagliere A., Raduazzo I.D., Nardi M., Schiff S., Gatta A., Merkel C., Amodio P., Achermann P., and Montagnese S. (2013) Ammonia-related changes in cerebral electrogenesis in healthy subjects and patients with cirrhosis. Clin. Neurophysiol., 124, 492-496.

Kurth S., Achermann P., Rusterholz T., and LeBourgeois M.K. (2013) Development of brain EEG connectivity across early childhood – does sleep play a role? Brain Sciences, 3, 1445-1460.

Latshang T.D., Lo Cascio C.M., Stöwhas A.C., Grimm M., Stadelmann K., Tesler N.,  Achermann P., Huber R., Kohler M., and Bloch K.E. (2013) Are nocturnal breathing, sleep and cognitive performance impaired at moderate altitude (1630-2590m)? Sleep, 36, 1969-1976.

LeBourgeois M.K., Carskadon M.A., Akacem L.D., Simpkin C.T., Wright K.P., Achermann P., and Jenni O.G. (2013) Circadian phase and its relationship to nighttime sleep in toddlers. J. Biol. Rhythms, 28, 322-331.
Loughran S.P., Benz D.C., Schmid M.R., Murbach M., Kuster N., and Achermann P. (2013) No increased sensitivity in brain activity of adolescents exposed to mobile phone-like emissions. Clin. Neurophysiol., 124, 1303-1308.
Lustenberger C., Murbach M., Dürr R., Schmid M.R., Kuster N., Achermann P., and Huber R. (2013) Stimulation of the brain with radiofrequency electromagnetic field pulses affects sleep-dependent performance improvement. Brain Stimul. 6, 805-811.
Meisel C., Olbrich E., Shriki O., and Achermann P. (2013) Fading signatures of critical brain dynamics during sustained wakefulness in humans. J. Neurosci., 33, 17363–17372.

Metz A. J., Pugin F., Huber R., Achermann P.*, and Wolf M.* (2013) Brain tissue oxygen saturation increases during the night in adolescents. Advances in Experimental Medicine and Biology, 789, 113-119.                                                                                  *shared last authorship

Stadelmann K., Latshang T.D., Lo Cascio C.M., Tesler N., Stöwhas A.C., Kohler M., Bloch K.E., Huber R., and Achermann P. (2013) Quantitative changes in the sleep EEG at moderate altitude (1630 m and 2590 m). PLoS ONE, 8(10): e76945

Stöwhas A.C., Latshang T.D., Lo Cascio C.M., Lautwein S., Stadelmann K., Tesler N., Ayers L., Berneis K., Gerber P., Huber R., Achermann P., Bloch K.E., and Kohler M. (2013) Effects of acute exposure to moderate altitude on vascular function, metabolism and systemic inflammation. PLoS ONE, 8(8): e70081.

*Tarokh L. and Achermann P. (2013) Sleep homeostasis. In: C. Kushida (Ed.) The Encyclopedia of Sleep, Vol.1, pp. 413-417. Waltham, MA: Academic Press.

2012  
Bersagliere A.#, Raduazzo I.D.#, Nardi M., Schiff S., Gatta A., Amodio P., Achermann P.*, and Montagnese S.* (2012) Induced hyperammonaemia may compromise the ability to generate restful sleep in patients with cirrhosis. Hepathology, 55, 869-78. # Joint first authorship; * Joint senior authorship
Geiger A., Huber R., Kurth S., Ringli M., Achermann P.* and Jenni O.G.* (2012) Sleep EEG topography and children's intellectual ability. Neuroreport, 23, 93 - 97. *Joint senior Authorship
Lustenberger C., Maric A., Dürr R., Achermann P. and Huber R. (2012) Triangular relationship between sleep spindle activity, general cognitive ability and the efficiency of declarative learning. PLoS One, 7 (11), e49561.
Murbach M., Christopoulou M., Crespo-Valero P., Achermann P. and Kuster N. (2012) Exposure system to study hypotheses of ELF & RF electromagnetic field interactions of mobile phones with the central nervous system. Bioelectromagnetic, 33, 527-33.
Schmid M.R.#, Loughran S.P.#, Regel S.J., Murbach M., Bratic Grunauer A., Rusterholz T., Bersagliere A., Kuster N., and Achermann P. (2012) Sleep EEG alterations: Effects of different pulse-modulated radio frequency electromagnetic fields. J. Sleep Res. 21, 50–58 #contributed equally to this work
Schmid M.R., Murbach M., Lustenberger C., Maire M., Kuster N., Achermann P.*, and Loughran S.P.* (2012) Sleep EEG alterations: Effects of pulsed magnetic fields vs. pulse-modulated radio frequency electromagnetic fields. J. Sleep Res., 21 (6), 620-629
*shared senior authorship
Tarokh L., Carskadon M.A., and Achermann P. (2012) Dissipation of sleep pressure is stable across adolscence. Neuroscience, 216, 167-177.
2011  
Crespo-Valero P., Christopoulou M., Zefferer M., Christ A., Achermann P., Nikita K.S., and Kuster N. (2011) Novel methodology to characterize electromagnetic exposure of the brain. Phys. Med. Biol. 56, 383-396.  
Geiger A., Huber R., Kurth S., Ringli M., Jenni O.G. * and Achermann P. * (2011) The sleep EEG as a marker of intellectual ability in school age children. Sleep 34, 181-189. *Joint senior Authorship  
Olbrich E., Claussen J.-C. and Achermann P. (2011) The multiple time scales of sleep dynamics as a challenge for modelling the sleeping brain. Phil. Trans. Roy. Soc. A. 369, 3884-3901.

Rusterholz  T. and  Achermann P. (2011)  Topographical aspects in the dynamics of sleep homeostasis in young men: Individual patterns. BMC Neuroscience 2011, 12:8.

Tarokh L., Carskadon M.A. and Achermann P. (2011) Trait-Like Characteristics of the Sleep EEG Across Adolescent Development. J. Neurrosci. 31, 6371-6378.  
Wennekers T., Achermann P., Olbrich E. The complexity of sleep. (2011) Philosophical transactions. Series A, undefined Mathematical, physical, and engineering sciences. Vol 369, No. 1952, 2011.
2010  
Achermann P. and Bersagliere A. (2010) Sleep homeostasis and slow oscillations in the human sleep EEG. Proceedings of Biosignal 2010, July 14-16, 2010, Berlin, Germany
Bersagliere A. and Achermann P. (2010) Slow oscillations in human nonREM sleep EEG: effects of increased sleep pressure. J Sleep Res. 19, 228-237.  
Geiger A., Achermann P. and Jenni O.G. (2010) Association between sleep duration and intelligence scores in healthy children. Developmental Psychology 46, 949-954.  
Geiger A., Huber R., Kurth S., Ringli M., Jenni O.G. and Achermann P. (2010) The sleep EEG as a marker of intellectual ability in school age children. Sleep, in press.  
Geiger A., Achermann P. and Jenni O.G. (2010) Sleep, intelligence and cognition from a developmental perspective: differentiation between traits and state-dependent aspects. Progress in Brain Research: Sleep and Cognition , 184, G. Kerkhof, H.P.A. Van Dongen (Eds.), in press.  
Rusterholz T., Dürr R. and Achermann P. (2010) Inter-individual differences in the dynamics of sleep homeostasis. Sleep 33, 491-498.  
Tarokh L., Carskadon M.A. and Achermann P. (2010) Developmental changes in brain connectivity assessed using the sleep EEG. Neurroscience 171, 622-634.  
2009  
Achermann P. (2009) EEG analysis applied to sleep. Epileptologie 26, 28-33.  
2008  
Boutry C. M., Kuehn S., Achermann P., Romann A., Keshvari J. and Kuster N. (2008) Dosimetric evaluation and comparison of different RF exposure apparatuses used in human volunteer studies. Bioelectromagnetics 29, 11-19.  
Hermann D. M., Wachter K., Mathis J., Achermann P. and Bassetti C. L. (2008) Evolution of neurological, neuropsychological and sleep-wake disturbances in paramedian thalamic stroke. Stroke 39, 62-68.  
Khatami R., Landolt H. P., Achermann P., Adam M., Rétey J. V., Werth E., Schmid D. and Bassetti C. L. (2008) Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation. Sleep 31, 859-867.  
Olbrich E. and Achermann P. (2008) Analysis of the temporal organization of sleep spindles in the human sleep EEG using a phenomenological modeling approach. J. Biol. Phys. 34, 341-349.  
Siccoli M. M., Rolli-Baumeler N., Achermann P. and Bassetti C. L. (2008) Correlation between sleep and cognitive functions after hemispheric ischaemic stroke. Eur. J. Neurol. 15, 565-572.  
2007  
Khatami R., Landolt H.-P., Achermann P., Rétey J.V, Werth E., Mathis J., Bassetti, C.L. (2007) Insufficient non-REM sleep intensity in narcolepsy-cataplexy. Sleep, 30, 980-989.  
Regel S.J., Gottselig J.M., Schuderer J., Tinguely G., Rétey J.V., Kuster N., Landolt H.-P. and Achermann P. (2007) Pulsed radio frequency radiation affects cognitive performance and the waking electroencephalogram. Neuroreport 18, 803-807.  
Regel S. J., Tinguely G., Schuderer J., Adam M., Kuster N., Landolt H. P. and Achermann P. (2007) Pulsed radio-frequency electromagnetic fields: dose-dependent effects on sleep, the sleep EEG and cognitive performance. J. Sleep Res. 16, 253-258.  
Tobler I. and Achermann P. (2007) Sleep homeostasis. Scholarpedia 2(10): 2432.  
Vyazovskiy V.V., Achermann P. and Tobler I. (2007) Sleep homeostasis in the rat in the light and dark period. Brain Res. Bull. 74, 37-44.  
2006    
Buckelmüller J., Landolt H.-P., Stassen H. H. and Achermann P. (2006) Trait-like individual differences in the human sleep electroencephalogram. Neuroscience 138, 351-356.  
Gottselig J.M., Adam M., Rétey J.V., Khatami R., Achermann P. and Landolt H.P. (2006) Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. J. Sleep Res. 14, 31-40.  
Jenni O.G., Deboer T. and Achermann P. (2006) Development of the 24-h rest-activity pattern in human infants. Infant Behavior & Development 29, 143-152.  
Landolt H.-P., Glatzel M., Blättler T., Achermann P., Roth C., Mathis J., Weis J., Tobler I., Aguzzi A., and Bassetti C.L. (2006) Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease. Neurology 66, 1418-1424.  
Regel S.J., Negovetic S., Röösli M., Berdińas V., Schuderer J., Huss A., Lott U., Kuster N., and Achermann P. (2006) UMTS base station-like exposure, well being and cognitive performance. Environmental Health Perspectives 114, 1270-1275.  
Retéy, J.V., Adam M., Gottselig J.M., Khatami R., Dürr R., Achermann P., and Landolt H.-P. (2006) Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic activity. J. Neurosci., 26, 10472-10479.  
Tinguely G., Huber R., Borbély A.A. and Achermann P. (2006) Non-rapid eye movement sleep with low muscle tone as a marker of rapid eye movement sleep regulation. BMC Neuroscience, 7:2 (9 January 2006).  
Tinguely G., Finelli L.A., Landolt H.-P., Borbély A.A. and Achermann P. (2006) Functional EEG topography in sleep and waking: State-dependent and state-independent features. NeuroImage 32, 283-292.  
2005  
Hofer-Tinguely G., Achermann P., Landolt H.P., Regel S. J., Rétey J.V., Dürr R., Borbély A.A. and Gottselig J.M. (2005) Sleep inertia: performance changes after sleep, rest and active waking. Cog. Brain Res. 22, 323-331.  
Huber R., Treyer V., Schuderer J., Berthold T., Buck A., Kuster N., Landolt H.P. and Achermann P. (2005) Exposure to pulse-modulated radio frequency electromagnetic fields affects regional cerebral blood flow. Eur. J. Neurosci. 21, 1000-1006.  
Jenni O.G., Achermann P. and Carskadon M.A. (2005) Homeostatic sleep regulation in adolescents. Sleep 28, 1446-1454.  
Olbrich E. and Achermann P. (2005) Analysis of oscillatory patterns in the human sleep EEG using a novel detection algorithm. J. Sleep Res. 14, 337-346.  
2004    
Gottselig J.M., Brandeis D., Hofer-Tinguely G., Borbély A.A. and Achermann P. (2004) Human central auditory plasticity associated with tone sequence learning. Learn. Mem. 11, 162-171.  
Gottselig J.M., Hofer-Tinguely G., Borbély A.A., Regel J., Landolt H.-P., Rétey J.V. and Achermann P. (2004) Sleep and rest facilitate auditory learning. Neuroscience 127, 557-561.  
Jenni O.G., Borbély A.A. and Achermann P. (2004) Development of the nocturnal sleep electroencephalogram in human infants. Am. J. Physiol. Regul. Integr. Comp. Physiol. 286, R528-R538.  
Landolt H.-P., Rétey J.V., Tönz K., Gottselig J.M., Khatami R., Buckelmüller I. and Achermann P. (2004) Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans. Neuropsychopharmacology 29, 1933-1939.  
Olbrich E. and Achermann P. (2004) Oscillatory events in the human sleep EEG - detection and properties. Neurocomputing 58-60, 129-135.  
Vyazovskiy V., Achermann P., Borbély A.A. and Tobler I. (2004) Interhemispheric coherence of the sleep electroencephalogram in mice with congenital callosal dysgenesis. Neuroscience 124, 481-488.  
Vyazovskiy V.V., Achermann P., Borbély A.A. and Tobler I. (2004) The dynamics of spindles and EEG slow-wave activity in NREM sleep in mice. Arch. Ital. Biol. 142, 511-523.  
2003    
Huber R., Schuderer J., Graf T., Jütz K., Borbély A.A., Kuster N. and Achermann P. (2003) Radio frequency electromagnetic field exposure in humans: Estimation of SAR distribution in the brain, effects on sleep and heart rate. Bioelectromagnetics 24: 262-276.  
Kunz H.P. and Achermann P. (2003) Simulation of circadian rhythm generation in the suprachismatic nucleus with locally coupled self-sustained oscillators. J. Theor. Biol., 224: 63-78.  
Olbrich E., Achermann P. and Meier P.F. (2003) Dynamics of human sleep EEG. Neurocomputing 52-54: 857-862.  
Shen Y., Olbrich E., Achermannn P. and Meier P. F. (2003) Dimensional complexity and spectral properties of the human sleep EEG. Clin. Neurophysiol. 114, 199-209.  
2002    
Gottselig J. M., Bassetti C. L. and Achermann P. (2002) Power and coherence of sleep spindle frequency activity following hemispheric stroke. Brain 125, 373-383.  
Huber R., Treyer V., Borbély A., Schuderer J., Gottselig J., Landolt H.-P., Werth E., Berthold T., Kuster N., Buck A. and Achermann P. (2002) Electromagnetic fields, such as those from mobile phones, alter regional cerebral blood flow and sleep and waking EEG. J. Sleep Res. 11 289-295.  
Müller C., Achermann P., Bischof M., Nirkko A.C., Roth C. and Bassetti C. (2002) Visual and spectral analysis of sleep EEG in acute hemispheric stroke. Eur. Neurol. 48, 164-171.  
Vock J., Achermann P., Bischof M., Milanova M., Müller C., Nirkko A., Roth C. and Bassetti C.L. (2002) Evolution of sleep and sleep EEG after hemispheric stroke. J. Sleep Res. 11, 331-338.  
Werth E., Cote K.A., Gallmann E., Borbély A.A. and Achermann P. (2002) Selective REM sleep deprivation during daytime sleep. I. Time course of interventions and recovery sleep. Am. J. Physiol. Regul. Integr. Comp. Physiol., R521-R526.  
Werth E., Achermann P. and Borbély A.A. (2002) Selective REM sleep deprivation during daytime. II. Muscle atonia in non-REM sleep. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283, R527-R532.  
2001  
Achermann P., Finelli L. A. and Borbély A. A. (2001) Unihemispheric enhancement of delta power in human frontal sleep EEG by prolonged wakefulness. Brain Res. 913, 220-223. IF 2.296  
Finelli L. A., Achermann P. and Borbély A. A. (2001) Individual 'fingerprints' in human sleep EEG topography. Neuropsychopharmacology 25, S58-S62.  
Finelli L. A., Borbély A. A. and Achermann P. (2001) Functional topography of the human nonREM sleep electroencephalogram. Eur. J. Neurosci. 13, 2282-2290. IF 3.949  
Graf T., Engeler J., Achermann P., Mosimann U. P., Noss R., Fisch H. and Schlaepfer T. E. (2001) High frequency repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral cortex: EEG topography during waking and subsequent sleep. Psychiatry Research: Neuroimaging Section 107, 1-9.  
Lehmann D., Faber P. L., Achermann P., Jeanmonod D., Gianotti L. R. R. and Pizzagalli D. (2001) Brain sources of EEG gamma frequency during volitionally mediation-induced, altered states of consciousness, and experience of the self. Psychiatry Research: Neuroimaging Section 108, 111-121.  
2000  
Finelli L. A., Baumann H., Borbély A. A. and Achermann P. (2000) Dual electroencephalogram markers of human sleep homeostasis: correlation between theta activity in waking and slow-wave activity in sleep. Neuroscience 101, 523-529.  
Finelli L. A., Landolt H. P., Buck A., Roth C., Berthold T., Borbély A. A. and Achermann P. (2000) Functional neuroanatomy of human sleep states after zolpidem and placebo: a H215O-PET study. J. Sleep Res. 9, 161-173.  
Huber R., Graf T., Cote K. A., Wittmann L., Gallmann E., Matter D., Schuderer J., Kuster N., Borbély A. A. and Achermann P. (2000) Exposure to pulsed high-frequency electromagnetic field during waking affects human sleep EEG. Neuroreport 11, 3321-3325.  
Landolt H. P., Finelli L. A., Roth C., Buck A., Achermann P. and Borbély A. A. (2000) Zolpidem and sleep deprivation: Different effect on EEG power spectra. J. Sleep Res. 9, 175-183.  
Roth C., Jeanmonod D., Magnin M., Morel A. and Achermann P. (2000) Effects of medial thalamotomy and pallido-thalamic tractotomy on sleep and waking EEG in pain and Parkinsonian patients. Clin. Neurophysiol. 111, 1266-1275.  

 

EDITORIALS

Olbrich E., Achermann P., and Wennekers T. (2011) The sleeping brain as a complex system. Phil. Trans. Roy. Soc. A., 369: 3697-3707.  

 

REVIEWS

Regel S.J. and Achermann P. (2011) Cognitive Performance Measures in Bioelectromagnetic Research - Critical Evaluation and Recommendations. Environmental Health 10, 10.
Achermann P. (2004) The two-process model of sleep regulation revisited. Aviat. Space Environ. Med. 75, A37-A43.
Achermann P. and Borbély A.A. (2003) Mathematical models of sleep regulation. Frontiers in Bioscience 8: 683-693.  

 

BOOK CHAPTERS

Tarokh L. and Achermann P. (2013) Sleep homeostasis. In: Encyclopedia of Sleep, Kushida C. (Ed.), Vol. 1, pp. 413-417. Waltham, MA: Academic Press.
Achermann P. and Borbély A.A. (2011) Sleep homeostasis and models of sleep regulation. In: Principles and Practice of Sleep Medicine, 5th Edition, Kryger M.H., Roth T. and Dement W.C. (Eds.), Elsevier Saunders, Missouri, 431-444.
Achermann P. (2006) Sleep. The Wiley Encyclopedia of Biomedical Engineering.
Borbély A.A. and Achermann P. (2005) Sleep homeostasis and models of sleep regulation. In: Principles and Practice of Sleep Medicine, 4th Edition, Kryger M.H., Roth T. and Dement W.C. (Eds.), Elsevier Saunders, Philadelphia 405-417.
Borbély A. A., Dijk D. J., Achermann P. and Tobler I. (2001) Processes underlying the regulation of the sleep-wake cycle. In: Circadian Clocks (ed. J. A. Takahashi, F. W. Turek, and R. Y. Moore), pp. 457-479. Kluwer Academic / Plenum Publishers.
Achermann P. (2000) Topography of the sleep EEG in humans: power and coherence analysis. In: The Regulation of Sleep, Vol. 8 (ed. A. A. Borbély, O. Hayaishi, T. Sejnowski, and J. S. Altman), pp. 75-86. HFSP - Human Frontier Science Program.  
Borbély A. A. and Achermann P. (2000) Sleep homeostasis and models of sleep regulation. In: Principles and Practice of Sleep Medicine 3rd Edition (ed. M. H. Kryger, T. Roth, and W. C. Dement), pp. 377-390. W.B. Saunders Co.  

 

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