Institute of Pharmacology and Toxicology – Chronobiology and Sleep Research

Research Areas  



Clark I and Landolt HP. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev. 2016, 2016 Jan 30. pii: S1087-0792(16)00015-0.
Holst SC, Valomon A and Landolt HP. Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy. Annu Rev Pharmacol Toxicol. 2016, Jan 6;56:577-603.
Landolt HP. CIRCADIAN RHYTHMS. Caffeine, the circadian clock, and sleep. Science. 2015, Sep 18;349(6254):1289.
Dauvilliers Y, Tafti M and Landolt HP. Catechol-O-methyltransferase, dopamine and sleep-wake regulation. Sleep Med Rev. 2015, Aug;22:47-53.
Urry E and Landolt HP. Adenosine, caffeine and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics. Curr Top Behav Neurosci. 2015;25:331-66.
Tinguely G, Landolt HP and Cajochen C. [Sleep habits, sleep quality and sleep medicine use of the Swiss population result]. Ther Umsch. 2014, Nov;71(11):637-46.
Thomann J, Baumann CR, Landolt HP and Werth E. Psychomotor vigilance task demonstrates impaired vigilance in disorders with excessive daytime sleepiness. J Clin Sleep Med. 2014, Sep 15;10(9):1019-24.
Chellappa SL, Viola AU, Schmidt C, Bachmann V, Gabel V, Maire M, Reichert CF, Valomon A, Landolt HP and Cajochen C. Light modulation of human sleep depends on a polymorphism in the clock gene Period3. Behav Brain Res. 2014, Sep 1;271:23-9.
Valomon A, Holst SC, Bachmann V, Viola AU, Schmidt C, Zürcher J, Berger W, Cajochen C and Landolt HP. Genetic polymorphisms of DAT1 and COMT differentially associate with actigraphy-derived sleep-wake cycles in young adults. Chronobiol Int. 2014, Jun;31(5):705-14.
Olbrich E, Landolt HP and Achermann P. Effect of prolonged wakefulness on electroencephalographic oscillatory activity during sleep. J Sleep Res. 2014, Jun;23(3):253-60.
Reichert CF, Maire M, Gabel V, Viola AU, Kolodyazhniy V, Strobel W, Götz T, Bachmann V, Landolt HP Cajochen C and Schmidt C. Insights into behavioral vulnerability to differential sleep pressure and circadian phase from a functional ADA polymorphism. J Biol Rhythms. 2014, Apr;29(2):119-30.
Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, and Landolt HP. Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci. 2014, Jan 8;34(2):566-73.
Maire M, Reichert CF, Gabel V, Viola AU, Krebs J, Strobel W, Landolt HP. Bachmann V, Cajochen C and Schmidt C. Time-on-task decrement in vigilance is modulated by inter-individual vulnerability to homeostatic sleep pressure manipulation. Front Behav Neurosci.. 2014 Mar 6;8:59.
Reichert CF, Maire M, Gabel V, Hofstetter M, Viola AU, Kolodyazhniy V, Strobel W, Goetz T, Bachmann V, Landolt HP Cajochen C and Schmidt C. The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements. PLoS One. 2014, 9(12):e113734.
Bosch OG, Rihm JS, Scheidegger M, Landolt HP, Stämpfli P, Brakowski J, Esposito F, Rasch B, and Seifritz E. Sleep deprivation increases dorsal nexus connectivity to the dorsolateral prefrontal cortex in humans. Proc Natl Acad Sci USA, 110, 19597-15602 (2013
Hefti K, Holst SC, Sovago J, Bachmann V, Buck A, Ametamey SM, Scheidegger M, Bethold T, Gomez-Mancilla B, Seifritz E and Landolt HP. Increased metabotropic glutamate receptor subtype 5 availability in human brain after one night without sleep. Biol Psychiatry, 73, 161-168 (2013)
Landolt HP, Rétey JV and Adam M. Reduced neurobehavioral impairment from sleep deprivation in older adults: Contribution of adenosinergic mechanisms. Front Neurol, 3, 62 (2012)
Chellappa SL, Viola AU, Schmidt C, Bachmann V, Gabel V, Maire M, Reichert CF, Valomon A, Götz T, Landolt HP and Cajochen C. Human melatonin and alerting response to blue-enriched light depend on a polymorphism in the clock gene PER3. J Clin Endocrinol Metab, 97, E433-E437 (2012)
Bachmann V, Klein C, Bodenmann S, Schäfer N, Berger W, Brugger P and Landolt HP. The BDNF Val66Met polymorphism modulates sleep intensity: EEG frequency- and state-specificity. Sleep, 35, 335-344, (2012)
Bodenmann S, Hohoff C, Freitag C, Deckert J, Rétey JV, Bachmann V and Landolt HP. Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioral performance and sleep EEG after sleep deprivation. Br J Pharmacol, 165, (2012)
Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, Berger W and Landolt HP. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex, (2011) in press.
Bodenmann S, Landolt HP. Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT and differ from those of caffeine. Sleep 33, 1027 -035 (2010)
Bodenmann S, Rusterholz T, Dürr R, Stoll C, Bachmann V, Geissler E, Jaggi-Schwarz K and Landolt HP. The Functional Val158Met Polymorphism of COMT Predicts Inter-individual Differences in Brain Alpha Oscillations in Young Men. J Neurosci 29: 10855-10862 (2009)
Bodenmann S, Xu S, Luhmann UFO, Arand M, Berger W, Jung HH and Landolt HP Pharmacogenetics of modafinil after sleep loss: Catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep. Clin Pharmacol Ther 85 (2009)
Diekelmann S, Landolt HP, Lahl O, Born J, Wagner U.
Sleep loss produces false memories. PLoS ONE 3, e3512 (2008)
Khatami R, Landolt HP*, Achermann P, Adam M, Rétey JV, Werth E, Schmid D and Bassetti CL* Challenging sleep homeostasis in narcolepsy-cataplexy: Implications for nonREM and REM sleep regulation. Sleep 31, 859-867 (* shared senior authorship) (2008)
Khatami R, Landolt HP, Achermann P, Rétey JV, Werth E, Mathis J and Bassetti CL
Insufficient nonREM sleep intensity in narcolepsy-cataplexy. Sleep 30, 978-987 (2007)
Rétey JV, Adam M, Khatami R, Luhmann UFO, Jung HH, Berger W, Landolt HP. A genetic variation on the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81: 692-698 (2007) 
Rétey JV, Adam M, Gottselig JM, Khatami R, Dürr R, Achermann P, Landolt HP. Adenosinergic mechanisms contribute to individual differences in sleep-deprivation induced changes in neurobehavioral function and brain rhythmic activity. J Neurosci 26: 10472-10479 (2006) 
Gottselig JM, Adam M, Rétey JV, Khatami R, Achermann P, Landolt HP. Random number generation during sleep deprivation: Effects of caffeine on response maintenance and stereotypy. J Sleep Res 15: 31-40 (2006)
Adam M, Rétey JV, Khatami R, Landolt HP. Age-related changes in the time course of vigilant attention during 40 hours without sleep in men. Sleep 29: 55-57 (2006)
Landolt HP, Glatzel M, Blattler T, Achermann P, Roth C, Mathis J, Weis J, Tobler I, Aguzzi A, Bassetti C. Sleep-wake disturbances in sporadic Creutzfeldt-Jakob disease. Neurology 66: 1418-1424 (2006)
Buckelmüller J, Landolt HP, Stassen HH, Achermann P. Trait-like individual differences in the human sleep EEG. Neuroscience, 138: 351-356 (2006)
Rétey JV, Adam M, Honegger E, Khatami R, Luhmann U, Jung HH, Berger W, Landolt HP (2005). A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci USA, 102: 15676-15681 (2005)
Landolt HP, Gillin JC. Similar sleep EEG topography in middle-aged depressed patients and healthy controls. Sleep, 28: 239-247 (2005)



Landolt HP. Genetic effects. In: Encyclopedia of Sleep. Kushida C . (Ed.). Vol. 1, Academic Press, pp. 251-256, 2013.
Holst SC, and Landolt HP. Die Rolle metabotroper Glutamat-Rezeptoren vom Subtyp 5 bei den Folgen von Schlafentzug. Swiss Med Forum 13, 970-971, 2013.
Landolt HP, and Urry E. Functional neuroimaging: Sedating medication effects. In: Neuroimaging of sleep and sleep disorders. Nofzinger E, Maquet P and Thorpy M (Eds.) Cambridge University Press, Cambridge, UK, pp. 395-405, 2013
Landolt HP (2012) “No Thanks, Coffee Keeps Me Awake”: Individual Caffeine Sensitivity Depends on ADORA2A Genotype. Sleep 35, 899-900.
Landolt HP, (2012). Génétique du Sommeil Normal et des Rythmes Circadiens. In: Les Troubles du Sommeil. Billiard M, Dauvilliers Y (Eds). 2nd edition. pp. 45-57
Landolt HP, (2011). Sleep homeostasis, adenosine, caffeine, and narcolepsy. In: Narcolepsy and Hypersomnia. Bassetti CL, Scammell TE, Baumann CR (Eds). Humana Press, Springer, New York pp. 85-92
Landolt HP, (2011). Genetic effects. In: Encyclopedia of Sleep. Kushida CA (Ed). In press.
Landolt HP, (2011) Genetic determination of sleep EEG profiles in healthy humans. Prog Brain Res 193, 51-61
Landolt HP, Dijk DJ (2011). Genetic Basis of Sleep in Healthy Humans. In: Principles and Practice of Sleep Medicine. Kryger MH (Ed.). 5th edition. pp. 175-183.
Landolt HP, Wehrle R (2009). Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood? Eur J Neurosci 29, 1795-1809.
Landolt HP, Genotype-dependent differences in sleep, vigilance and response to stimulants. Curr Pharm Des, 14:3396-3407 (2008)
Landolt HP, Sleep homeostasis: a role for adenosine in humans? Biochem Pharmacol, 75, 2070-2079 (2008)