PUBLICATIONS

RESEARCH PUBLICATIONS

2017  

Gaspar L, Howald C, Popadin K, Maier B, Mauvoisin D, Moriggi E, Gutierrez-Arcelus M, Falconnet E, Borel C, Kunz D, Kramer A, Gachon F, Dermitzakis ET, Antonarakis SE, and Brown SA The genomic landscape of human cellular circadian variation points to a novel role for the signalosome. Elife 2017 Sep 4;6 (2017)

 
Azzi, A., Evans, J.A., Leise, T., Myung, J., Takumi, T., Davidson, A.J., and Brown, S.A Network dynamics mediate circadian clock plasticity. Neuron, Neuron 2017 Jan 18;93(2):441-450 (2017) DOWNLOAD (PDF, 3239 KB)
2016  

Jansen HT, Leise T, Stenhouse G, Pigeon K, Kasworm W, Teisberg J, Radandt T, Dallmann R, Brown S, Robbins CT. The bear circadian clock doesn't 'sleep' during winter dormancy.  Front Zool. Sep 17;13:42 (2016)

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2015  
Mircsof D, Langouët M, Rio M, Moutton S, Siquier-Pernet K, Bole-Feysot C, Cagnard N, Nitschke P, Gaspar L, Žnidarič M, Alibeu O, Fritz AK, Wolfer DP, Schröter A, Bosshard G, Rudin M, Koester C, Crestani F, Seebeck P, Boddaert N, Prescott K; DDD Study, Hines R, Moss SJ, Fritschy JM, Munnich A, Amiel J, Brown SA, Tyagarajan SK and Colleaux L. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects. Nat Neurosci. Dec;18(12):1731-6. (2015)
Drägert K, Bhattacharya I, Pellegrini G, Seebeck P, Azzi A, Brown SA, Georgiopoulou S, Held U, Blyszczuk P, Arras M, Humar R, Hall MN, Battegay E and Haas E. Deletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure. Hypertension. Aug;66(2):332-9. (2015)
Li X, Martinez-Lozano Sinues P, Dallmann R, Bregy L, Hollmén M, Proulx S, Brown SA, Detmar M, Kohler M and Zenobi R. Drug Pharmacokinetics Determined by Real-Time Analysis of Mouse Breath. Angew Chem Int Ed Engl. Jun 26;54(27):7815-8. (2015)
Saini C, Brown SA and Dibner C. Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology. Front Neurol. May 13;6:95. (2015)
Gaspar L and Brown SA. Measuring circadian clock function in human cells. Methods Enzymol. 552:231-56. (2015)
2014  
Azzi A, Dallmann R, Casserly A, Rehrauer H, Patrignani A, Maier B, Kramer A, and Brown SA. Circadian behavior is light-reprogrammed by plastic DNA methylation. Nat Neurosci. 17:377-82. (2014)
Gaspar L, van de Werken M, Johansson A-S, Moriggi E, Owe-Larsson B, Kocks JWH, Lundkvist GB, Gordijn MCM and Brown SA. Human cellular differences in cAMP - CREB signaling correlate with light-dependent melatonin suppression and bipolar disorder. Eur J Neurosci. 40:2206–2215. (2014)
Martinez-Lozano Sinues P, Tarokh L, Li X, Kohler M, Brown SA, Zenobi R and Dallmann R. Circadian variation of the Human metabolome captured by real-time breath analysis. PLoS One 9(12):e114422. (2014)
2013  
Kowalska E, Ripperger JA, Hoegger DC, Bruegger P, Buch T, Birchler T, Mueller A, Albrecht U, Contaldo C, and Brown SA. NONO couples the circadian clock to the cell cycle. Proc Natl Acad Sci USA 110:1592-9. (2013)
2012  
Kowalska E, Ripperger JA, Muheim C, Maier B, Kurihara Y, Fox AH, Kramer A, and Brown SA. Distinct roles of DBHS family members in the circadian transcriptional feedback loop. Mol Cell Biol. 32:4585-94. (2012)
Dallmann R, Viola AU, Tarokh L, Cajochen C, and Brown SA. The human circadian metabolome. Proc. Natl Acad Sci USA, 109(7):2625-9. (2012)
2011  
Pagani L, Schmitt K, Meier F, Izakovic J, Roemer K, Viola A, Cajochen C, Wirz-Justice A, Brown SA, and Eckert A. Serum factors in older individuals change cellular clock properties. Proc. Natl Acad Sci USA, 108(17):7218-7223. (2011)
2010  
Pagani L, Semenova EA, Moriggi E, Revell VL, Hack LM, Lockley SW, Arendt J, Skene DJ, Meier F, Izakovic J, Wirz-Justice A, Cajochen C, Sergeeva OJ, Cheresiz SV, Danilenko KV, Eckert A, and Brown SA. The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts. PLoS ONE, 5(10):E13376. (2010)
Kowalska E, Moriggi E, Bauer C, Dibner C, and Brown SA. The circadian clock starts ticking at a developmentally early stage. J Biol Rhythms 25, 442-9. (2010)
2008  
Brown SA*, Kunz D, Dumas A, Westermark PO, Vanselow K, Tilmann-Wahnschaffe A, Herzel H, Kramer A. Molecular insights into human daily behavior. Proc. Natl. Acad Sci USA 105:1602-1607. (*corresponding authorship), (2008)
2005  
Brown SA, Ripperger J, Kadener S, Fleury-Olela F, Vilbois F, Rosbash M, Schibler U. PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science 308: 693-696. (2005)
Brown SA, Fleury-Olela F, Nagoshi E, Hauser C, Juge C A, Meier CA, Chicheportiche R, Dayer JM, Albrecht U, and Schibler U. The period length of fibroblast circadian gene expression varies widely among human individuals.PLoS Biology 3, e338. (2005) 
2003  
He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, and Calderwood SK. Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. J Biol Chem 278: 35465-75.
2002  
Brown SA, Zumbrunn G, Fleury-Olela F, Preitner N, and Schibler U. Rhythms of mammalian body temperature can sustain peripheral circadian clocks. Curr Biol. 12:1574-1583. (2002)
2000  
Balsalobre A, Brown SA, Marcacci L, Tronche F, Kellendonk C, Reichardt HM, Schutz G, and Schibler U. Resetting of circadian time in peripheral tissues by glucocorticoid signalling. Science 289:2344-2347. (2000)
1998  
Brown SA, Weirich CS, Newton EM, and Kingston RE. Transcriptional activation domains stimulate initiation and elongation at different times and via different residues. EMBO J. 17:3146-3154. (1998)
1997  
Brown SA and Kingston RE. Disruption of downstream chromatin directed by a transcriptional activator. Genes Dev. 11:3116-3121. (1997)
1996  
Brown SA, Imbalzano AN, and Kingston RE. Activator-dependent regulation of transcriptional pausing on chromatin templates. Genes Dev. 10:1479-1490. (1996)
1992  
Hirschhorn JN, Brown SA, Clark CD, and Winston F. Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure. Genes Dev. 6:2288-2298. (1992)
Albrecht U.The Circadian Clock. New York, Vol. 12, 2010

REVIEWS

 

Brown SA. Circadian Metabolism: From Mechanisms to Metabolomics and Medicine. Trends Endocrinol Metab. Jun;27(6):415-26. (2016)

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Langouët M, Mircsof D, Rio M, Amiel J, Brown SA, Colleaux L. Mutations in NONO lead to syndromic intellectual disability and inhibitory synaptic defects Med Sci (Paris). Jun-Jul;32(6-7):571-3 (2016)

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Benegiamo G, Brown SA, Panda S. RNA Dynamics in the Control of Circadian Rhythm. Adv Exp Med Biol. 907:107-22 (2016)

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Gaspar L, Brown SA. Measuring circadian clock function in human cells. Methods Enzymol. 552:231-56 (2015)

DOWNLOAD (PDF, 571 KB)

Saini C, Brown SA, Dibner C. Human peripheral clocks: applications for studying circadian phenotypes in physiology and pathophysiology. Front Neurol. May 13;6:95 (2015)

DOWNLOAD (PDF, 2684 KB)

Bassetti CL, Ferini-Strambi L, Brown S, Adamantidis A, Benedetti F, Bruni O, Cajochen C, Dolenc-Groselj L, Ferri R, Gais S, Huber R, Khatami R, Lammers GJ, Luppi PH, Manconi M, Nissen C, Nobili L, Peigneux P, Pollmächer T, Randerath W, Riemann D, Santamaria J, Schindler K, Tafti M, Van Someren E, Wetter TC. Neurology and psychiatry: waking up to opportunities of sleep. : State of the art and clinical/research priorities for the next decade. Eur J Neurol. Oct;22(10):1337-54 (2015)

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Brown SA. Circadian clock-mediated control of stem cell division and differentiation: beyond night and day. Development, 141(16):3105-11 (2014)
Dallmann R, Brown SA, and Gachon F. Chronopharmacology: New Insights and Therapeutic Implications. Ann Rev Pharmacol Toxicol, 54:339-361. (2014)
Brown SA and Azzi A. Peripheral Circadian Oscillators in Mammals. Handb. Exp. Pharmacology, 217:45-66. (2013)
Mircsof D and Brown SA. The influence of light, exercise, and behavior upon circadian rhythms. In: Kushida C. (ed.) The Encyclopedia of Sleep, 1:435-441. (2013)
Muheim C and Brown SA. Adenosine and Other Purinergic Products in Circadian Timing. In S. Masino and D. Boison (eds.), Adenosine: A Key Link between 213 Metabolism and Brain Activity, pp. 212-223. (2013)
Brown SA, Kowalska E, and Dallmann R. (Re)inventing the circadian feedback loop. Dev Cell, 13; 22(3):477-87 (2012)
Brown SA. Circadian rhythms. A new histone code for clocks? Science 333, 1833-4. (2011)
Brown SA, Schmidt K, and Eckert A. Aging and Circadian Disruption: Causes and Effects.Aging, August, Vol. 3, No. 8. (2011)
Brown SA, Pagani L, Cajochen C, and Eckert A. Systemic and cellular reflections on ageing and the circadian oscillator - A mini-review. Gerontology, 57(5):427-434. (2011)
Pagani L, Eckert A, Brown SA. Studying human circadian bevaviour using peripheral cells. In: Clelland JD. Genomics, Proteomics and the Nervous System. New York, 729-302. (2011) Verlag
Rippberger JA, Brown SA. Transcriptional regulation of circadian clocks. In: Albrecht U. The Circadian Clock. New York, Vol. 12, 2:37-78. (2010) Verlag
Brown SA, Pagani L, Cajochen C, Eckert A. Systemic and cellular reflections on ageing and the circadian oscillator - A mini-review. Gerontology, 57(5):427-434. (2010)
Cuninkova L, Brown SA. Peripheral Circadian Oscillators: Interesting mechanisms and powerful tools. Annals NY. Acad Sci 1129:358-370. (2008) 
Kowalska E and Brown SA. Peripheral clocks: keeping up with the mater clock. Cold Spring Harb Symp Quant Biol 72:301-5. (2007) .
Brown SA, Schibler U. Les rythmes circadiennes – dans le peau. Medecine et Science, 22:474-5. (2006)
Schibler U and Brown SA. Enlightening the adrenal gland. Cell Metab. 2:278-81. (2005)
Nagoshi E, Brown SA, Dibner C, Kornmann B, and Schibler U. Circadian gene expression in cultured cells. Methods Enzymol. 393:543-57. (2005)
Gachon F, Nagoshi E, Brown SA, Ripperger J, Schibler U. The mammalian circadian timing system: from gene expression to physiology. Chromosoma  113:103-12. (2004)
Preitner N, Brown SA, Ripperger J, Le-Minh N, Damiola F, and Schibler U. Orphan nuclear receptors, molecular clockwork, and the entrainment of peripheral oscillators. Novartis Found Symp 253:89-99; discussion: 99-109. (2003)
Schibler U, Ripperger J, Brown SA. Peripheral circadian oscillators in mammals: time and food. J. Biol. Rhythms 18:250-260. (2003)
Schibler U, Brown SA, and Ripperger J. The mammalian circadian timing system. In the Handbook of Cell Signaling, Elsevier Science, USA, Volume 3:139-143. (2003)
Schibler U, Ripperger J, Brown SA. Chronobiology -- reducing time. Science 293:437-438. (2001) 
Brown SA and Schibler U. Circadian rhythms: mop up the clock! Curr Biol. 11:R268-270. (2001) 
Brown SA, Schibler U. The ins and outs of circadian timekeeping.Curr Opin Genet Dev. 9:588-594. (1999)